UCLA Molecular and Medical Pharmacology  









Faculty

Department / Division Affiliations
Norton Simon Professor, Molecular & Medical Pharmacology
Chair, Molecular & Medical Pharmacology
Director, Crump Institute for Molecular Imaging
Member, ACCESS Program: Dept. of Molecular & Medical Pharmacology
Director, Institute for Molecular Medicine
ACCESS Affinity Group:
ACCESS Affinity - Molecular & Medical Pharmacology
Research Interest:
Molecular Imaging from preclinical to clinical: Biological Imaging and Neurosciences

Research focuses on the merger of biology and imaging to provide the means to examine molecular and cellular function in tissue cultures, as well as integrated organ function in animals and humans. These biological imaging assays are developed and integrated into biology and pharmacology based problems. Autoradiographic studies of cerebral metabolism, protein synthesis and gene expression are used in animals to study brain maturation, neuronal plasticity and compensatory reorganization to disease or injury. The anatomical expression of novel connections due to brain lesions promoting compensatory reorganization of the brain is determined by anterograde and retrograde tracing techniques, and their neurotrophic basis by in situ hybridization and gene knock-out techniques. Positron Emission Tomography (PET) is employed to map out gene expression, metabolic maturation, responses to select stimuli and learning, as well as compensatory reorganization of the brain in mice, monkeys and children. PET is also used to study the biological basis of human disorders such as epilepsy, Parkinson's and Alzheimer's, as well as alterations in neurochemical function by cocaine and methamphetamine.
Bio:
Michael Phelps, the Norton Simon Professor and Chair of the UCLA Department of Molecular and Medical Pharmacology, has been on the faculty of the University of California since 1976. He is actively engaged in medical research, educational programs and multimedia technologies at UCLA. Dr. Phelps uniquely holds six academic positions at UCLA. In addition to serving as the Departmental Chairman and holding an endowed professorship, he is also the Director of the Crump Institute for Molecular Imaging, Professor of Biomathematics, the Director of the Institute for Molecular Medicine and the Chief of Nuclear Medicine.

He has received numerous awards, among them, the 1992 Pasarow Foundation Award, the 1987 Rosenthal Foundation Award of the American College of Physicians, the George Von Hevesy Prize (won twice) from the Von Hevesy Foundation in Zurich (Von Hevesy won the Nobel Prize in Chemistry), the 1984 Sarah L. Poiley Memorial Award from the New York Academy of Sciences, the 1984 Ernest O. Lawrence Presidential Award, the 1983 Paul Aebersold Award from the Society of Nuclear Medicine, chaired the 1983 Nobel Symposium, elected to the Institute of Medicine of the National Academy of Sciences in 1985, Enrico Fermi Presidential Award, 1998, elected to the National Academy of Sciences in 1999.

Dr. Phelps is the original inventor of PET (Positron Emission Tomography). PET is a molecular imaging technique that provides in vivo images of biological processes, blood flow, metabolism, cell communication systems, drug interactions and gene expression. PET is used in research to study the biological basis of normal organ function and the biological basis of disease. It is also routinely used as a clinical service in the early detection, characterization and evaluation of the therapeutic responses in cancer, neurological disorders and cardiovascular disease.

He has published over 520 scientific papers and books.

 

Michael Phelps, Ph.D.

Email Address:
mphelps@mednet.ucla.edu

Address:
Office
CHS
Los Angeles, CA 90095
UNITED STATES

Phone Number:
310-825-6539


Login to the Faculty Database


Publications:
Vladimir Kepe, Jorge R. Barrio, Sung-Cheng Huang, Linda Ercoli, Prabha Siddarth, Kooresh Shoghi-Jadid, Gregory M. Cole, Nagichettiar Satyamurthy, Jeffrey L. Cummings, Gary W. Small, and Michael E. Phelps "Serotonin 1A Receptors in the Living Brain of Alzheimer's Disease Patients". PNAS. 2006; 103(3): 702-707.
Fueger BJ, Czernin J, Hildebrandt I, Tran C, Halpern BS, Stout D, Phelps ME, Weber WA, Impact of Animal Handling on the Results of 18F-FDG PET Studies in Mice. J Nucl Med 2006; 47: 999-1006.
Kepe V, Barrio JR, Huang S-C, Shoghi-Jadid K, Ercoli L, Siddarth P, Cole GM, Satyamurthy N, Cummings JL, Small GW, Phelps ME Serotonin 1A Receptors in the Living Brain of Alzheimer's Disease Patients. Proc Natl Acad Sci U.S.A. 2006; 103: 720-727.
Gangloff A, Hsueh W-A, Kesner AL, Kiesewetter DO, Pio BS, Pegram MD, Malgorzata B, Townsend A, Eckelman W, Czernin J, Phelps ME, Silverman DHS. Estimation of Paclitaxel Biodistribution and Uptake in Human-Derived Xenografts in vivo with [18F]-fluoropaclitaxel. J Nucl Med 2005; 46: 1866-1871.
Kepe V, Cole GM, Liu J, Shoghi-Jadid K, Flood DG, Trusko SP, Satyamurthy N, Huang S-C, Small GW, Petric A, Phelps ME, Barrio JR. FDDNP Micropet Imaging of beta-Amyloid Deposits in the Living Brain of Triple Transgenic Rat Model of beta-Amyloid Deposition. Mol Imag and Biol 2005; 7: 105-106.
Wu HM, Kreissl MC, Schelbert HR, Ladno W, Prins M, Shoghi-Jadid K, Chatziioannou A, Phelps ME, and Huang SC. First-Pass Angiography in Mice Using FDG-PET: A Simple Method of Deriving the Cardiovascular Transit Time Without the Need of Region-of-Interest Drawing. . IEEE Transact on Nucl Sci 5 2005; 52(October 2005): 5.
Yaghoubi SS, Barrio JR, Namavari M, Satyamurthy N, Phelps ME, Herschman HR, Gambhir SS. Imaging Progress of Herpes Simplex Virus Type I thymidine Kinase Suicide Gene Therapy in Living Subjects with Positron Emission Tomography. Cancer Gene Therapy 2005; 12: 329-339.
Chen W, Cloughesy T, Kamdar N, Satyamurthy N, Liau L, Bergsneider M, Mischel P, Czernin J, Phelps ME, Silverman DH. Imaging Proliferation in Brain Tumors with 18F-FLT PET: Comparison with FDG. . J Nucl Med 2005; 46: 945-952.
Phelps, M. Phillips, A. Darley, M. Blaydes, J. P. MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm. J Biol Chem. 2005; 280(17): 16651-8.
Waldherr C, Mellinghoff IK, Tran C, Halpern BS, Rozengurt N, Safaei A, Stout D, Satyamurthy N, Barrio J, Phelps ME, Silverman DH, Sawyers CL, Czernin J. Monitoring Antiproliferative Responses to Kinase Inhibitor Therapy in Mice with 3'-Deoxy-3'[18F]Fluorothymidine(FLT)-PET. J Nucl Med 2005; 46(114-20): .
Lee C-C, Sui G, Elizarov A, Shu CJ, Shin Y-S, Dooley AN, Huang J, Daridon A, Wyatt P, Stout D, Kolb HC, Witte ON, Satyamurthy N, Heath JR, Phelps ME, Quake SR, Tseng HR Multistep Synthesis of a Radiolabeled Imaging Probe Using Integrated Microfluidics. Science 2005; 310: 1793-1796.
Penuelas I, Mazzolini G, Boan JF, Sangro B, Marti-Climent J, Ruiz M, Ruiz J, Satyamurthy N, Qian C, Barrio JR, Phelps ME, Richter JA, Gambhir SS, Prieto J. Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients. . Gastroenterology 2005; 128(7): 1787-95.
Huang S-C, Truong D, Wu A, Wu HM, Chatziioannou A, Satyamurthy N, Barrio J, Phelps ME. Simulation of Whole-Body Kinetics for Evaluation of Bio-Markers. Mol Imag and Biol 2005; 7: 135.
Stout DB, Chatziioannou AF, Lawson TP, Silverman RW, Gambhir SS, Phelps ME Small Animal Imaging Center Design: The Facility at the UCLA Crump Institute for Molecular Imaging. Mol Imaging Biol 2005; 7(6): 393-402.
Toyokuni T, Kumar JSD, Walsh JC, Shapiro A, Talley JJ, Phelps ME, Herschman HR, Barrio JR, Satyamurthy N Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography. Bioorg Med Chem Lett 2005; 15: 4699-4702.
Phelps, M. In tribute of Edward J. Hoffman, PhD (1942-2004). Mol Imaging Biol. 2004; 6(5): 271-4.
Hood, L Heath, JR Phelps, ME Lin, B Systems biology and new technologies enable predictive and preventative medicine.. Science. . 2004; 306(5696): 640-3.
Phelps, M. A. Foraker, A. B. Swaan, P. W. Cytoskeletal motors and cargo in membrane trafficking: opportunities for high specificity in drug intervention. Drug Discov Today. 2003; 8(11): 494-502.
Heath, JR Phelps, ME Hood, L NanoSystems biology.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. . 2003; 5(5): 312-25.
Phelps, M. Darley, M. Primrose, J. N. Blaydes, J. P. p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells. Cancer Res. 2003; 63(10): 2616-23.
Phelps, M. A. Rodriguez, R. M. Passanante, M. Dresden, G. Kriza, K. EMS activation in a cohort of critically ill patients. J Emerg Med. 2002; 22(2): 127-31.
Ray, P Pimenta, H Paulmurugan, R Berger, F Phelps, ME Iyer, M Gambhir, SS Noninvasive quantitative imaging of protein-protein interactions in living subjects.. Proceedings of the National Academy of Sciences of the United States of America. . 2002; 99(5): 3105-10.
Liang Q, Gotts J, Satyamurthy S, Barrio J, Phelps ME, Gambhir SS, Herschman HR Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus.. Molec Therapy 2002; 6: 73-82.
Phelps, M. E. Nuclear medicine, molecular imaging, and molecular medicine. J Nucl Med. 2002; 43(2): 13N-14N.