UCLA Molecular and Medical Pharmacology  









Faculty

Department / Division Affiliations
Professor, Molecular & Medical Pharmacology
Member, ACCESS Program: Dept. of Molecular & Medical Pharmacology, Cancer Molecular Imaging, DOE Funded Faculty
Faculty, Crump Institute for Molecular Imaging
ACCESS Affinity Group:
ACCESS Affinity - Molecular & Medical Pharmacology
Research Interest:
Tracer kinetic modeling, PET, image analysis, computer: We study the delivery, transport, metabolism and receptor binding of labeled compounds and drugs in local tissue regions in vivo, using the methodologies of quantitative PET, tracer kinetics and modeling. Tracer kinetic models are formulated and validated based on experimental biochemical information. Based on the validated models, practical study procedures and reliable estimation techniques are developed to obtain quantitative biological information in vivo in humans. Major emphasis is on the understanding of basic mechanisms related to the uptake, clearance and metabolism of labeled compounds under various conditions. Biological parameters studied include blood perfusion, glucose utilization rate, oxygen consumption rate, dopamine D2 receptor density, and fluoroDOPA decarboxylation rate.
 

Sung-Cheng (Henry) Huang, Sc.D.

Email Address:
hhuang@mednet.ucla.edu

Address:
Office
CHS
Los Angeles, CA 90095
UNITED STATES

Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES

Phone Number:
310-825-4517
Phone Number:
310-794-6675
310-825-6647


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Publications:
Huang SC Anatomy of SUV (Standardized Uptake Value).. Nuclear Medicine & Biology 2000; 27: 643-646.
Bergsneider, M Hovda, DA McArthur, DL Etchepare, M Huang, SC Sehati, N Satz, P Phelps, ME Becker, DP Metabolic recovery following human traumatic brain injury based on FDG-PET: time course and relationship to neurological disability.. The Journal of head trauma rehabilitation. . 2001; 16(2): 135-48.
Shoghi-Jadid K, Small GW, Agdeppa ED, Kepe V, Ercoli LM, Siddarth P, Read S, Satyamurthy N, Petric A, Huang SC, Barrio JR Localization of Neurofibrillary Tangles (NFTs) and Beta-Amyloid Plaques (APs) in the Brains of Living Patients with Alzheimer?s Disease.. Am J. Geriatric Psychiatry 2002; 10: 24-35.
Zhou Y, Huang SC, Bergsneider M, Wong DF Improved parametric image generation using spatial-temporal analysis of dynamic PET studies, Neuroimaging.. 2002; 15: 697-707.
Huang, SC Stout, DB Yee, RE Satyamurthy, N Barrio, JR Distribution volume of radiolabeled large neutral amino acids in brain tissue.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. . 1998; 18(12): 1288-93.
Huang SC, Quintana J, Satyamurthy N, Lacan G, Yu DC, Phelps ME, Barrio JR [F-18]fluoro-b-fluoromethylene-m-tyrosine derivatives show stereo-,geometric and regio specificity as in-vivo central dopaminergic probes in monkeys.. Nucl Med and Biol 1999; 26: 365-370.
Shoghi-Jadid K, Huang SC, Stout DB, Yee RE, Yeh EL, Farahani KF, Satyamurthy N, Phelps ME, Barrio JR Striatal kinetic modeling of FDOPA with a cerebellar-derived constraint on the distribution volume of 3OMFD: a positron emission tomography (PET) investigation using non-human primates.. J. Cereb. Blood Flow Metab 2000; 20: 1134-1148.
Small, GW Ercoli, LM Silverman, DH Huang, SC Komo, S Bookheimer, SY Lavretsky, H Miller, K Siddarth, P Rasgon, NL Mazziotta, JC Saxena, S Wu, HM Mega, MS Cummings, JL Saunders, AM Pericak-Vance, MA Roses, AD Barrio, JR Phelps, ME Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease.. Proceedings of the National Academy of Sciences of the United States of America. . 2000; 97(11): 6037-42.
Yee, RE Huang, SC Stout, DB Irwin, I Shoghi-Jadid, K Togaski, DM DeLanney, LE Langston, JW Satyamurthy, N Farahani, KF Phelps, ME Barrio, JR Nigrostriatal reduction of aromatic L-amino acid decarboxylase activity in MPTP-treated squirrel monkeys: in vivo and in vitro investigations.. Journal of neurochemistry. . 2000; 74(3): 1147-57.
Bergsneider, M Hovda, DA Lee, SM Kelly, DF McArthur, DL Vespa, PM Lee, JH Huang, SC Martin, NA Phelps, ME Becker, DP Dissociation of cerebral glucose metabolism and level of consciousness during the period of metabolic depression following human traumatic brain injury.. Journal of neurotrauma. . 2000; 17(5): 389-401.
Choi Y, Huang SC, Hawkins RA, Kim JY, Kim BT, Hoh CK, Chen K, Phelps ME, Schelbert HR Quantification of myocardial blood flow using N-13 ammonia and PET: comparison of tracer methods.. J. Nucl. Med. 1999; 40: 1045-1055.
Huang SC Image oscillation reduction and convergence acceleration for OS-EM reconstruction.. IEEE Trans. Nucl. Sci 1999; 46: 607-607.
Huang, Sung-Cheng, Zhou, Yun Spatially-coordinated regression for image-wise model fitting to dynamic PET data for generating parametric images... IEEE Transactions on Nuclear Science 1998; 45: 1194-1199.
Chinn, G Huang, SC A general class of preconditioners for statistical iterative reconstruction of emission computed tomography.. IEEE transactions on medical imaging. . 1997; 16(1): 1-10.
Yang, J., Huang, S.C., Mega, M., Lin, K.P., Toga, A.W., Small, G.W., Phelps, M.E. Investigation of partial volume correction methods for brain FDG PET studies. (fluorodeoxyglucose; positron emission tomography).. IEEE Transactions on Nuclear Science 1996; 43: 3322-3327.
Huang, SC Wu, HM Shoghi-Jadid, K Stout, DB Chatziioannou, A Schelbert, HR Barrio, JR Investigation of a new input function validation approach for dynamic mouse microPET studies.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. . 2004; 6(1): 34-46.
Wu, HM Huang, SC Hattori, N Glenn, TC Vespa, PM Yu, CL Hovda, DA Phelps, ME Bergsneider, M Selective metabolic reduction in gray matter acutely following human traumatic brain injury.. Journal of neurotrauma. . 2004; 21(2): 149-61.
Hattori, N Huang, SC Wu, HM Liao, W Glenn, TC Vespa, PM Phelps, ME Hovda, DA Bergsneider, M PET investigation of post-traumatic cerebral blood volume and blood flow.. Acta neurochirurgica. Supplement. . 2003; 86: 49-52.
Agdeppa, ED Kepe, V Liu, J Small, GW Huang, SC Petric, A Satyamurthy, N Barrio, JR 2-Dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): novel diagnostic and therapeutic tools in Alzheimer's disease.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. . 2003; 5(6): 404-17.
Hattori, N Huang, SC Wu, HM Yeh, E Glenn, TC Vespa, PM McArthur, D Phelps, ME Hovda, DA Bergsneider, M Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injury.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. . 2003; 44(11): 1709-16.
Yee, RE Huang, SC Togasaki, DM Langston, JW Satyamurthy, N Barrio, JR Imaging and therapeutics: the role of neuronal transport in the regional specificity of L-DOPA accumulation in brain.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. . 2002; 4(3): 208-18.
Wu HM, Bergsneider M, Glenn TC, Yeh E, Hovda DA, Phelps ME, Huang SC. Measurement of the global lumped constant for 2-deoxy-2-[18F]fluoro-D-glucose in normal human brain using [15O]water and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography imaging. A method with validation based on multiple methodologies.. Mol Imaging Biol. 2003; 5(1):: 32-41.
Agdeppa ED, Kepe V, Petri A, Satyamurthy N, Liu J, Huang SC, Small GW, Cole GM, Barrio JR. In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile.. Neuroscience. 2003; 117(3):: 723-30.
Small, GW Agdeppa, ED Kepe, V Satyamurthy, N Huang, SC Barrio, JR In vivo brain imaging of tangle burden in humans.. Journal of molecular neuroscience : MN. . 2002; 19(3): 323-7.
Kudo T, Fukuchi K, Annala AJ, Chatziioannou AF, Allada V, Dahlbom M, Tai YC, Inubushi M, Huang SC, Cherry SR, Phelps ME, Schelbert HR. Noninvasive measurement of myocardial activity concentrations and perfusion defect sizes in rats with a new small-animal positron emission tomograph.. Circulation 2002; 106(1):: 118-23.
Saxena, S Brody, AL Ho, ML Alborzian, S Maidment, KM Zohrabi, N Ho, MK Huang, SC Wu, HM Baxter, LR Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression.. Archives of general psychiatry. . 2002; 59(3): 250-61.
Wu, H.M., Huang, S.C.,Hattori, N., Glenn, T.C., Vespa, P.M., Hovda, D.A., Bergsneider, M. Subcortical white matter metabolic changes remote from focal hemorrhagic lesions suggest diffuse injury following human traumatic brain injury (TBI). Neurosurgery 2004; 55(6): 1306-1317.