UCLA Molecular and Medical Pharmacology  









Faculty

Department / Division Affiliations
Director, Center for Addictive Behaviors
Professor, Psychiatry and Biobehavioral Sciences, Molecular & Medical Pharmacology
Member, ACCESS Departments, ACCESS Program: Dept. of Molecular & Medical Pharmacology, Neuroscience Graduate Program, Brain Research Institute
Research Interest:
Neuroimaging brain function in addictive and other neuropsychiatric disorders: The projects in my laboratory focus on the neurobiology of substance abuse and development of new probes for the study of brain function by external imaging. Using positron emission tomography (PET) scanning and magnetic resonance imaging, our current projects concern dependence on methamphetamine and nicotine. The questions that we are asking in our human research relate to the links between genetics, cognitive function, affect and vulnerability to drug abuse and the maintenance of dependence. Correlative studies in animal models of addiction will relate altered neuronal function with gene expression, as affected by drug treatments. The goal is to develop a better understanding of the neurobiology of addiction, using a translational approach toward rational design of therapeutics.
 

Edythe London, Ph.D.

Email Address:
elondon@mednet.ucla.edu

Address:
Office
NPI
Los Angeles, CA 90095
UNITED STATES

Laboratory
NPI
Los Angeles, CA 90095
UNITED STATES

Phone Number:
(310) 825-0812
Phone Number:
(310) 825-0606


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Publications:
A Azizian, L Nestor, D Payer, JR Monterosso, AL Brody, ED London Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task. Neuropsychopharmacology (in press) ; .
B Lee, ED London, RA Poldrack, J Farahi, A Nacca, JR Monterosso, JA Mumford, AV Bokarius, M Dahlbom, J Mukherjee, RM Bilder, AL Brody, MA Mandelkern Striatal dopamine D2/D3 receptor availability is reduced in methamphetamine dependence and linked to impulsivity. J. Neurosci. (in press) ; .
SM Berman, RT Kuczenski, JT McCracken, ED London Potential adverse effects of amphetamine treatment on brain and behavior: a review. Mol. Psychiatry 2009; 14(2): 123-142.
AC Dean, ED London, CA Sugar, CMR Kitchen, A-N Swanson, KG Heinzerling, AD Kalechstein, S Shoptaw Predicting adherence to treatment for methamphetamine dependence from neuropsychological and drug use variables. Drug Alcohol Depend. 2009; 105(1-2): 48-55.
SM Berman, J O’Neill, S Fears, G Bartzokis, ED London Abuse of amphetamines and structural abnormalities in brain. Ann. N.Y. Acad. Sci. 2008; (1141): 195-220.