Faculty

Department / Division Affiliations

Associate Professor, Molecular & Medical Pharmacology

Member, ACCESS Program: Dept. of Molecular & Medical Pharmacology, JCCC Cancer Translational Therapeutics Program Area, Neuroengineering Training Program, Neuroscience Graduate Program, Brain Research Institute

ACCESS Affinity Group:

ACCESS Affinity - Genetics & Genomics

Research Interest:
Functional Neurogenomics: We are interested in understanding how the genome constructs the brain, in both health and disease. One research direction is the development of technologies for genome-scale acquisition of expression patterns in the brain. These methods, voxelation and gene expression tomography, survey both the transcriptome and proteome and combine the mathematical concepts of biomedical imaging with the high-throughput analytic tools of genomics. Another research interest is the use of genetic mapping to identify loci influencing behavior in the mouse. We are also developing new methods to improve the power and utility of genomics in general. One approach employs the concepts of error-correcting codes to improve microarray performance and another uses hyperspectral imaging to speed hybridization assays. The ultimate goal of our research is to decode the conceptual wiring diagram of the genome which gives rise to the neuronal wiring diagram of the brain.

For more detailed information, please visit the lab website.

Desmond Smith, M.D., Ph.D.

Email Address:
dsmith@mednet.ucla.edu

Address:
Office
CHS
Los Angeles, CA 90095
UNITED STATES

Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES

23-120 CHS
Campus - 173517
CA
UNITED STATES

Phone Number:
310-206-0086
310-794-5711

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Publications:

Chin MH, Geng AB, Khan AH, Qian WJ, Petyuk VA, Boline J, Levy S, Toga AW, Smith RD, Leahy RM, Smith DJ. A genome-scale map of expression for a mouse brain section obtained using voxelation. Physiol Genomics 2007; 30: 313-321.

Petyuk VA, Qian WJ, Chin MH, Wang H, Livesay EA, Monroe ME, Adkins JN, Jaitly N, Anderson DJ, Camp DG 2nd, Smith DJ, Smith RD. Spatial mapping of protein abundances in the mouse brain by voxelation integrated with high-throughput liquid chromatography-mass spectrometry. Genome Res 2007; 17: 328-336.

Leil TA, Ossadtchi A, Nichols TE, Leahy RM, Smith DJ. Genes regulated by learning in the hippocampus.. J Neurosci Res. 2003; 71: 763-768.

Sforza DM, Smith DJ. Genetic and genomic strategies in learning and memory.. Curr Genomics 2003; 4:: 475-485.

Liu D, Singh RP, Khan AH, Lusis AJ, Davis RC, Smith DJ Mapping behavioral traits by use of genome-tagged mice.. The American Journal of Geriatric Psychiatry 2003; 12(2): 158-65.

Shai S-Y, Harpf AE, Babbitt CJ, Jordan MC, Fishbein MC, Chen J, Omura M, Leil TA, Becker, KD, Jiang M, Smith DJ, Cherry SR, Loftus JC, Ross RS. Cardiac-specific Cre-lox excision of the beta 1 integrin gene results in progressive fibrosis, defective mechanotransduction and cardiac failure.. Circ Res 2002; 90: 458-464.

Smith DJ. Chips for brains.. Curr Genomics 2002; 3: 1-5.

Leil TA, Ossadtchi A, Cortes J, Leahy RM, Smith DJ. Finding new candidate genes for learning and memory.. J Neurosci Res 2002; 68: 127-137.

Brown VM, Ossadtchi A, Khan AH, Gambhir SS, Cherry SR, Leahy RM, Smith DJ. Gene expression tomography.. Physiol Genomics. 2002; 8: 159-167.

Brown VM, Ossadtchi A, Khan AH, Cherry SR, Leahy RM, Smith DJ. High-throughput imaging of brain gene expression.. Genome Res. 2002; 12: 244-254.

Smith DJ, Lusis AJ. The allelic structure of common disease.. Hum Mol Genetics. 2002; 11: 2455-2461.

Smith, DJ In vivo libraries of large insert transgenic mice for genetic mapping.. Methods in Molecular Biology 2001; 158: 335-349.

Smith, DJ RAGE and PRAY. The Pharmacogenomics Journal 2001; 1(2): 90-91.

Xie CW, Sayah D, Chen QS, Wei WZ, Smith DJ, Liu, X. Deficient long-term memory and long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene. Proc Natl Acad Sci USA. 2000; 97: 8116-8121.

Davis RC, Schadt EE, Smith DJ, Hsieh EW, Cervino AC, van Nas A, Rosales M, Doss S, Meng H, Allayee H, Lusis AJ. A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background. Genomics 2005; 86: 259-270.

Sforza DM, Annese J, Liu D, Levy S, Toga AW, Smith DJ Anatomical methods for voxelation of the mammalian brain. Neurochemical Research 2004; 29(6): 1299-306.

Singh RP, Liu D, Chaudhari A, Cherry SR, Leahy RM, Smith DJ Investigation of different transcript quantitation tools for high-throughput mapping of brain gene expression using voxelation. Journal of Molecular Histology 2004; 35(4): 397-402.

Branchi I, Bichler Z, Minghetti L, Delabar JM, Malchiodi-Albedi F, Gonzalez MC, Chettouh Z, Nicolini A, Chabert C, Smith DJ, Rubin EM, Migliore-Samour D, Alleva E Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration. Journal of Neuropathology and Experimental Neurology 2004; 63(5): 429-440.

Sforza DM, Smith DJ Voxelation methods for genome scale imaging of brain gene expression.. Methods in enzymology. . 2004; 386: 314-23.

Liu D, Smith DJ Voxelation and gene expression tomography for the acquisition of 3-D gene expression maps in the brain.. Methods (San Diego, Calif.) . 2003; 31(4): 317-25.

Liu D, Singh RP, Khan AH, Bhavsar K, Lusis AJ, Davis RC, Smith DJ Identifying loci for behavioral traits using genome-tagged mice.. Journal of neuroscience research. . 2003; 74(4): 562-9.

Singh RP, Smith DJ Genome scale mapping of brain gene expression.. Biological psychiatry. . 2003; 53(12): 1069-74.

Singh RP, Brown VM, Chaudhari A, Khan AH, Ossadtchi A, Sforza DM, Meadors AK, Cherry SR, Leahy RM, Smith DJ High-resolution voxelation mapping of human and rodent brain gene expression.. Journal of Neuroscience Methods. 2003; 125(1-2): 93-101.

Smith DJ, Leil TA, Liu X Neurotrophin-4 is required for tolerance to morphine in the mouse. Neuroscience Letters 2003; 340(2): 103-6.

Khan AH, Ossadtchi A, Leahy RM, Smith DJ Error-correcting microarray design.. Genomics. . 2003; 81(2): 157-65.

Ossadtchi A, Brown VM, Khan AH, Cherry SR, Nichols TE, Leahy RM, Smith DJ Statistical analysis of multiplex brain gene expression images.. Neurochemical research. . 2002; 27(10): 1113-21.

Brown VM, Ossadtchi A, Khan AH, Yee S, Lacan G, Melega WP, Cherry SR, Leahy RM, Smith DJ, Multiplex three-dimensional brain gene expression mapping in a mouse model of Parkinson's disease.. Genome research. . 2002; 12(6): 868-84.

Sayah DM, Khan AH, Gasperoni TL, Smith DJ A genetic screen for novel behavioral mutations in mice.. Molecular psychiatry. . 2000; 5(4): 369-77.

Hodgson JG, Agopyan N, Gutekunst CA, Leavitt BR, LePiane F, Singaraja R, Smith DJ, Bissada N, McCutcheon K, Nasir J, Jamot L, Li XJ, Stevens ME, Rosemond E, Roder JC, Phillips AG, Rubin EM, Hersch SM, Hayden MR A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.. Neuron. . 1999; 23(1): 181-92.

Sago H, Carlson EJ, Smith DJ, Kilbridge J, Rubin EM, Mobley WC, Epstein CJ, Huang TT Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.. Proceedings of the National Academy of Sciences of the United States of America. . 1998; 95(11): 6256-61.

Rubin EM, Smith DJ Optimizing the mouse to sift sequence for function.. Trends in genetics : TIG. . 1997; 13(11): 423-6.

Smith DJ, Stevens ME, Sudanagunta SP, Bronson RT, Makhinson M, Watabe AM, O'Dell TJ, Fung J, Weier HU, Cheng JF, Rubin EM Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome.. Nature genetics. . 1997; 16(1): 28-36.

Hamilton BA, Smith DJ, Mueller KL, Kerrebrock AW, Bronson RT, van Berkel V, Daly MJ, Kruglyak L, Reeve MP, Nemhauser JL, Hawkins TL, Rubin EM, Lander ES The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression.. Neuron. . 1997; 18(5): 711-22.