Faculty

Department / Division Affiliations

Assistant Professor, Molecular & Medical Pharmacology

Member, ACCESS Program: Dept. of Molecular & Medical Pharmacology, Cancer Molecular Imaging, ACCESS, Crump Institute for Molecular Imaging

Research Interest:
PET Imaging Approaches to Monitor T Lymphocyte Activation in Cancer and Autoimmunity: Inflammatory and immune disorders are major public health concerns and novel non-invasive approaches are needed for disease diagnosis, monitoring and accelerating new therapeutics testing. Positron Emission Tomography (PET) imaging of metabolic activity has been used extensively in cancer diagnosis and evaluation, with more than 3 million PET scans administered in clinical centers worldwide in 2005. However, PET applications in autoimmunity, inflammation and monitoring cancer immunotherapy have been limited. Our current research is directed in several areas: (i) development of novel PET probes to image T lymphocyte activation and inflammation; (ii), evaluation of cancer immunotherapy using PET reporter gene approaches; (iii), development of non-immunogenic PET reporter gene systems.

Caius Radu

Email Address:
cradu@mednet.ucla.edu

Address:
UCLA Crump Institute
700 Westwood Plaza
Box 951770
Los Angeles, CA 90095
UNITED STATES

Phone Number:
310-990-6488

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Publications:

Yang, L.V., Radu, C.G., Roy, M., Sunyoung Lee, S., McLaughlin, J., Michael A. Teitell, M.A., M. Luisa Iruela-Arispe, M.L., and Witte, O.N. Vascular Abnormalities in Mice Deficient for the G Protein-Coupled Receptor GPR4 That Functions as a pH Sensor. Mol Cell Biol 2007; 27(4): 1334-47.

Laing Rachel E, Walter Martin A, Campbell Dean O, Herschman Harvey R, Satyamurthy Nagichettiar, Phelps Michael E, Czernin Johannes, Witte Owen N, Radu Caius G Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography.. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(8): 2847-52.

Shu Chengyi J, Radu Caius G, Shelly Stephanie M, Vo Dan D, Prins Robert, Ribas Antoni, Phelps Michael E, Witte Owen N Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen.. International immunology. 2009; 21(2): 155-65.

Radu Caius G, Shu Chengyi J, Nair-Gill Evan, Shelly Stephanie M, Barrio Jorge R, Satyamurthy Nagichettiar, Phelps Michael E, Witte Owen N Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2'-deoxycytidine analog.. Nature medicine. 2008; 14(7): 783-8.

Bailey, R.C., Kwong, G.A, Radu, C.G., Witte, O.N., Heath, J.R. DNA-Encoded Antibody Libraries: A Unified Platform for Multiplexed Cell Sorting and Detection of Genes and Proteins. J Am Chem Soc 2007; .

Radu CG, Shu CJ, Shelly SM, Phelps ME, Witte ON Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2007; .

Radu, C.G., Cheng, D., Nijagal, A., Riedinger, M.,, McLaughlin, J., Yang, L.V, Johnson, J., and Witte, O. N. Normal Immune Development and Glucocorticoid-induced Thymocyte Apoptosis in Mice Deficient for the T cell Death-Associated Gene-8 Receptor. Mol Cell Biol 2006; 26(2): 668-77.

Shu, C. J., Guo, S., Kim, J.Y., Shelly, S., Ray, P., Gambhir, S.S., Radu, C.G., and Witte, O. N. Visualization of a primary anti-tumor immune response by positron emission tomography. PNAS 2005; 102(48): 17412-7.

Radu, C.G., Nijagal, A., McLaughlin, J., Wang, L., Witte, O.N. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. PNAS 2005; 102(5): 1632-7.

Yang, L.V., Radu, C.G., Wang, L., Riedinger, M., Witte, O.N. Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. Blood 2005; 105(3): 1127-34.

Radu, C.G., Yang, L.V., Riedinger, M., Au, M., Witte, O.N. T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. PNAS 2004; 101(1): 245-50.