FACULTY RESEARCH

Faculty List

Pei Yuin Keng, Ph.D.

Work Email Address: pkeng@mednet.ucla.edu

Office Phone Number: 3109833194

Work Address:
4321 CNSI, 570 Westwood Plaza
Los Angeles, CA 90095

Department / Division Affiliations
Assistant Professor, Molecular & Medical Pharmacology

Research Interests
Our research group is interested in developing new radiosynthetic strategies on microfluidic devices as the next generation chemistry tool kit to solve current bottle-neck in molecular imaging and cancer research. The Keng research group is multidisciplinary and collaborates extensively with other Crump faculty members and engineering groups to develop enabling microfluidic technologies for researchers and clinicians to produce diverse range of PET tracers on demand at the imaging site. The research focus includes (1) developing a robust microchemistry rule sets on microfluidic platforms to synthesize a wide range of F-18 labeled compounds, (2) designing new methodologies for fast and efficient radiolabeling reaction with simplified purification, (3) developing new radiofluorination approaches on the microscale to increase diversity and accessibility of radiotracers on microfluidics, (4) designing and integrating dedicated polymeric solid phase support for radiosynthesis and purification of PET tracers on microfluidic platforms.


Publications
Keng, P. Y., Chen, S. Ding, H.-J. Sadeghi, S., Phelps, M. E., Satyamurthy, N., Kim, C.-J. “CJ”, van Dam, R. Micro-chemical synthesis of molecular probes on an electronic microfluidic device. Proceedings of the National Academy of Science 2012; 109(3): 690-695.
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Saman Sadeghi, Huijiang Ding, Gaurav J. Shah, Supin Chen, Pei Yuin Keng, Chang-Jin „CJ“ Kim, and R. Michael van Dam On chip droplet characterization: A practical, high-sensitivity measurement of droplet impedance in digital microfluidics. Anal Chem 2012; ASAP: .
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Keng, P. Y., Chen, S. Ding, H.-J. Sadeghi, S., Phelps, M. E., Satyamurthy, N., Kim, C.-J. “CJ”, van Dam, R. Electrowetting on dielectric digital microfluidic chips for multistep radiosynthesis of PET tracers. Proceedings to International Symposium Radiopharmaceutical Science (ISRS) 2011; .
Keng, P. Y., Bull, M., Shim, I., Nebesny, K., Armstrong, N. R., Sung, Y., Char, K., Pyun, J. Colloidal Polymerization of Ferromagnetic PS-CoNPs into 1-D Hollow Pt-Co3O4 Heterostructures with Enhanced Electrochemical and Catalytic Activities. J. Mater. Chem 2011; 23(5): 1120-1129.
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Chen, S., Keng, P. Y., van Dam, R. M., Kim, C.-J. ‚“CJ“. Electrowetting on dielectric digital microfluidic chips for multistep radiosynthesis of PET tracers. Proceedings to MicroTAS 2010. The 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen 2010; .
Dylan, B., Keng, P. Y., Beatrice, M. Pyun, J., Loy, D.A. Mechanically Reinforced Silica Aerogel Nanocomposite via Surface Initiated Atom Transfer Polymerizations. J. Mater. Chem 2010; 20(33): 6863-6865.
Chen, S., Keng, P. Y., van Dam, R. M., Kim, C.-J. ‚“CJ“. Synthesis of 18F-Labeled Probes on EWOD Platform for Positron Emission Tomography (PET) Preclinical Imaging. Proceedings of MEMS 2011. The 24th International Conference on Micro Electro Mechanical System, Cancun, MX 2010; .
Keng, P. Y.; Shim, I.; Bull, M.M.; Griebel, J.J.; Ratcliff, E.L.; Armstrong, N.R.; Pyun, J. Colloidal Polymerization of Polymer Coated Ferromagnetic Nanoparticles into Cobalt Oxide Nanowires. ASC Nano 2009; 3: 3143-3159.
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Benkoski, J., Deacon, R.; Land, B. H., Baird, L. M.; Breidenich, J. L. Srinivasan, R., Clatterbaugh, G.V., Keng, P. Y., Pyun, J Dipolar Assembly of Ferromagnetic Nanoparticles . Soft Matter 2009; 6: 602-609.
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Keng, P. Y.; Shim, I.; Korth, B. D.; Douglas, J. F.; Pyun, J Synthesis and Self-Assembly of Polymer-Coated Ferromagnetic Nanoparticles. ACS Nano 2007; 1(4): 279-292.
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Korth, B. D.; Keng, P.; Shim, I.; Bowles, S. E.; Tang, C.; Kowalewski, T.; Nebesny, K. W.; Pyun Polymer-Coated Ferromagnetic Colloids from Well-Defined Macromolecular Surfactants and Assembly into Nanoparticle Chains. J. Am. Chem. Soc 2006; 128(20): 6562-6563.
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