FACULTY RESEARCH
Faculty List
Huiying Li, Ph.D.
Work Email Address:
huiying@mednet.ucla.edu
Lab Number:
(310) 983-3212
Office Phone Number:
(310) 206-5585
Department Address:
Crump Institute for Molecular Imaging
Laboratory Address:
CNSI 4338
Office Address:
CNSI 4339
570 Westwood Plaza, Building 114
Crump Institute
Los Angeles, CA 90095
Department / Division Affiliations
| Assistant Professor, Molecular & Medical Pharmacology |
| Faculty, Crump Institute for Molecular Imaging |
Research Interests
My research interest is to understand the gene regulation and protein interaction networks in organisms at a systems level. I have previously applied bioinformatics, X-ray crystallography and gene expression profiling to study protein functions and interactions in metabolism and infectious diseases. My current research focuses on understanding the human microbiome (the collective genome of trillions of microorganisms in human microflora) and its interactions with the host in relation to human health and diseases. Using a systems biology approach, including high-throughput genome sequencing, metagenomic microarrays and computational modeling, the aim of the research is to detect signature microflora patterns and to develop diagnostic markers and therapeutics for microorganism-related human diseases. By combining computational and experimental approaches, the ultimate goal of my research is to understand the human-microflora symbiotic system at both molecular level and systems level.
Publications
|
Ochoa MT, Teles R, Haas BE, Zaghi D, Li H, Sarno EN, Rea TH, Modlin RL, Lee DJ A role for interleukin-5 in promoting increased immunoglobulin M at the site of disease in leprosy.
Immunology.
2010; 131(3):
405-14.
Ji H, Delker SL, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives.
J Med Chem.
2010; 53(21):
7804-24.
Lee, D. J. Li, H. Ochoa M. T. Tanaka, M. Carbone, R. J. Damoiseaux, R. Burdick, A. Sarno, E. N. Rea, T. H. Modlin, R. L. Integrated Pathways for Neutrophil Recruitment and Inflammation in Leprosy.
Journal of Infectious Diseases..
2010; 201(4):
558-569.
Grossman AR, Karpowicz SJ, Heinnickel M, Dewez D, Hamel B, Dent R, Niyogi KK, Johnson X, Alric J, Wollman FA, Li H, Merchant SS Phylogenomic analysis of the Chlamydomonas genome unmasks proteins potentially involved in photosynthetic function and regulation.
Photosynth Res.
2010; 106(1-2):
3-17.
Xue F, Li H, Delker SL, Fang J, Martásek P, Roman LJ, Poulos TL, Silverman RB Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase.
J Am Chem Soc.
2010; 132(40):
14229-38.
Li H, Monien BH, Lomakin A, et al.
INVESTIGATION OF A beta 42 C-TERMINAL FRAGMENTS AS INHIBITORS OF A beta 42 ASSEMBLY AND NEUROTOXICITY.
BIOPOLYMERS .
2009; 92(4):
324-324 .
Li H, Bitan G
SAR AND MECHANISTIC STUDIES OF TETRAPEPTIDE INHIBITORS OF A beta 42-INDUCED NEUROTOXICITY.
BIOPOLYMERS .
2009; 92(4):
324-324.
Loncaric A, Xu M, Liu P, Li H, et al.
Investigation of the resident skin biome through isolation and identification of propionibacterium acnes bacteriophages.
JOURNAL OF INVESTIGATIVE DERMATOLOGY .
2008; 128:
S196-S196 .
Tabita, F. R. Hanson, T. E. Li, H. Satagopan S. Singh J. Chan S. Function, structure, and evolution of the RubisCO-like proteins and their RubisCO Homologs.
Microbiology and Molecular Biology Reviews.
2007; 71(4):
576-599.
Li, H. Sawaya, M. R. Tabita, F. R. Eisenberg, D. Crystal structure of a RuBisCO-like protein from the green sulfur bacterium Chlorobium tepidum.
Structure (Camb).
2005; 13(5):
779-89.
Li, H. Pellegrini, M. Eisenberg, D. Detection of parallel functional modules by comparative analysis of genome sequences.
Nat Biotechnol.
2005; 23(2):
253-60.
Krutzik, S. R. Tan, B. <span face="bold" font="default" size="100%">Li, H. Ochoa, M. T. Liu, P. T. Sharfstein, S. E. Graeber, T. G. Sieling, P. A. Liu, Y. J. Rea, T. H. Bloom, B. R. Modlin, R. L. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.
Nat Med.
2005; 11(6):
653-60.
Li, H. Guo, Z. F. Zhu, Y. X. Molecular cloning and analysis of a pea cDNA that is expressed in darkness and very rapidly induced by gibberellic acid.
Mol Gen Genet.
1998; 259(4):
393-7.
Zhu, Y. Zhang, Y. <span face="bold" font="default" size="100%">Li, H. Molecular cloning of GA-suppressed G2 pea genes by cDNA RDA.
Science in China, Series C.
1997; 40:
379-83.
Yooseph, S., Li, H.,et al. The Sorcerer II Global Ocean Sampling Expedition: Expanding the Universe of Protein Families.
PLoS Biol.
2007; 5(3):
16.
Liu, P. T.* Stenger, S.* <span face="bold" font="default" size="100%">Li, H. Wenzel, L. Tan, B. H. Krutzik, S. R. Ochoa, M. T. Schauber, J. Wu, K. Meinken, C. Kamen, D. L. Wagner, M. Bals, R. Steinmeyer, A. Zugel, U. Gallo, R. L. Eisenberg, D. Hewison, M. Hollis, B. W. Adams, J. S. Bloom, B. R. Modlin, R. L. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.
Science.
2006; 311(5768):
1770-3. (*equal contribution).
Bleharski, J. R.* <span face="bold" font="default" size="100%">Li, H.* Meinken, C.* Graeber, T. G.* Ochoa, M. T. Yamamura, M. Burdick, A. Sarno, E. N. Wagner, M. Rollinghoff, M. Rea, T. H. Colonna, M. Stenger, S. Bloom, B. R. Eisenberg, D. Modlin, R. L. Use of genetic profiling in leprosy to discriminate clinical forms of the disease.
Science.
2003; 301(5639):
1527-30. (*equal contribution).
|