Faculty List

Jason T. Lee, Ph.D.

Email Address: JASONTLEE@mednet.ucla.edu

Lab Number: 310-794-2224

Office Phone Number: 310-825-7137

Crump Preclinical Imaging

Laboratory Address:
Preclinical Imaging Technology Center, Crump Institute for Molecular Imaging, CNSI 2112
Los Angeles, CA 90095

Office Address:
Crump Institute for Molecular Imaging, CNSI 2151
Los Angeles, CA 90095

Department / Division Affiliations
Assistant Professor, Crump Institute for Molecular Imaging, Molecular & Medical Pharmacology
Faculty, Crump Institute for Molecular Imaging

Research Interests
Our lab focuses on the development of in vivo molecular imaging techniques including positron emission tomography (PET), computed tomography (CT) and optical (fluorescence and bioluminescence) imaging, and their applications for non-invasive assessment of cancer and associated biology in small animal models. Specifically, we study preclinical imaging of cancer cell metabolism using probes such as the glucose analog FDG and nucleoside analogs FAC and FLT, reporter genes to monitor cell trafficking and activation, drug pharmacokinetic/pharmacodynamics and tracer kinetic modeling.

Chao Philip H, Collins Jeffery, Argus Joseph P, Tseng Wei-Yu, Lee Jason T, Michael van Dam R Automatic concentration and reformulation of PET tracers via microfluidic membrane distillation. Lab on a chip. 2017; 17(10): 1802-1816.
Lebedev Artem, Jiao Jing, Lee Jason, Yang Fan, Allison Nathanael, Herschman Harvey, Sadeghi Saman Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor. PloS one. 2017; 12(5): e0176606.
Demer Linda L, Tintut Yin, Nguyen Kim-Lien, Hsiai Tzung, Lee Jason T Rigor and Reproducibility in Analysis of Vascular Calcification. Circulation research. 2017; 120(8): 1240-1242.
Pillai Indulekha C L, Li Shen, Romay Milagros, Lam Larry, Lu Yan, Huang Jie, Dillard Nathaniel, Zemanova Marketa, Rubbi Liudmilla, Wang Yibin, Lee Jason, Xia Ming, Liang Owen, Xie Ya-Hong, Pellegrini Matteo, Lusis Aldons J, Deb Arjun Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification. Cell stem cell. 2017; 20(2): 218-232.e5.
Momcilovic Milica, Bailey Sean T, Lee Jason T, Fishbein Michael C, Magyar Clara, Braas Daniel, Graeber Thomas, Jackson Nicholas J, Czernin Johannes, Emberley Ethan, Gross Matthew, Janes Julie, Mackinnon Andy, Pan Alison, Rodriguez Mirna, Works Melissa, Zhang Winter, Parlati Francesco, Demo Susan, Garon Edward, Krysan Kostyantyn, Walser Tonya C, Dubinett Steven M, Sadeghi Saman, Christofk Heather R, Shackelford David B Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer. Cell reports. 2017; 18(3): 601-610.
Lee Jason T, Zhang Hanwen, Moroz Maxim A, Likar Yury, Shenker Larissa, Sumzin Nikita, Lobo Jose, Zurita Juan, Collins Jeffrey, van Dam R Michael, Ponomarev Vladimir Comparative Analysis of Human Nucleoside Kinase-Based Reporter Systems for PET Imaging. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2016; .
Boschi Stefano, Lee Jason T, Beykan Seval, Slavik Roger, Wei Liu, Spick Claudio, Eberlein Uta, Buck Andreas K, Lodi Filippo, Cicoria Gianfranco, Czernin Johannes, Lassmann Michael, Fanti Stefano, Herrmann Ken Synthesis and preclinical evaluation of an Al(18)F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand. European journal of nuclear medicine and molecular imaging. 2016; 40(4): .
Kim Woosuk, Le Thuc M, Wei Liu, Poddar Soumya, Bazzy Jimmy, Wang Xuemeng, Uong Nhu T, Abt Evan R, Capri Joseph R, Austin Wayne R, Van Valkenburgh Juno S, Steele Dalton, Gipson Raymond M, Slavik Roger, Cabebe Anthony E, Taechariyakul Thotsophon, Yaghoubi Shahriar S, Lee Jason T, Sadeghi Saman, Lavie Arnon, Faull Kym F, Witte Owen N, Donahue Timothy R, Phelps Michael E, Herschman Harvey R, Herrmann Ken, Czernin Johannes, Radu Caius G [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 2016; 48(4): .
Moroz Maxim A, Zhang Hanwen, Lee Jason, Moroz Ekaterina, Zurita Juan, Shenker Larissa, Serganova Inna, Blasberg Ronald, Ponomarev Vladimir Comparative analysis of T cell imaging with human nuclear reporter genes. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2015; 61(6): .
Nathanson David A, Armijo Amanda L, Tom Michelle, Li Zheng, Dimitrova Elizabeth, Austin Wayne R, Nomme Julian, Campbell Dean O, Ta Lisa, Le Thuc M, Lee Jason T, Darvish Ryan, Gordin Ari, Wei Liu, Liao Hsiang-I, Wilks Moses, Martin Colette, Sadeghi Saman, Murphy Jennifer M, Boulos Nidal, Phelps Michael E, Faull Kym F, Herschman Harvey R, Jung Michael E, Czernin Johannes, Lavie Arnon, Radu Caius G Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. The Journal of experimental medicine. 2014; 211(3): 473-86.
Murphy Jennifer M, Armijo Amanda L, Nomme Julian, Lee Chi Hang, Smith Quentin A, Li Zheng, Campbell Dean O, Liao Hsiang-I, Nathanson David A, Austin Wayne R, Lee Jason T, Darvish Ryan, Wei Liu, Wang Jue, Su Ying, Damoiseaux Robert, Sadeghi Saman, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Alexandrova Anastassia N, Jung Michael E, Lavie Arnon, Radu Caius G Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. Journal of medicinal chemistry. 2013; 56(17): 6696-708.
Lee Jason T, Campbell Dean O, Satyamurthy Nagichettiar, Czernin Johannes, Radu Caius G Stratification of nucleoside analog chemotherapy using 1-(2'-deoxy-2'-18F-fluoro-β-D-arabinofuranosyl)cytosine and 1-(2'-deoxy-2'-18F-fluoro-β-L-arabinofuranosyl)-5-methylcytosine PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2012; 53(2): 275-80.
Campbell Dean O, Yaghoubi Shahriar S, Su Ying, Lee Jason T, Auerbach Martin S, Herschman Harvey, Satyamurthy Nagichettiar, Czernin Johannes, Lavie Arnon, Radu Caius G Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe. The Journal of biological chemistry. 2012; 287(1): 446-54.
Shu Chengyi J, Campbell Dean O, Lee Jason T, Tran Andrew Q, Wengrod Jordan C, Witte Owen N, Phelps Michael E, Satyamurthy Nagichettiar, Czernin Johannes, Radu Caius G Novel PET probes specific for deoxycytidine kinase. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2010; 51(7): 1092-8.