FACULTY RESEARCH

Faculty List

Wei Wei, Ph.D.

Email Address: weiwei@mednet.ucla.edu
Work Email Address: weiwei@mednet.ucla.edu

Work Phone Number: 310-825-9488

UCLA-Caltech Translational Medicine Lab (TML)

Mailing Address:
Department of Molecular and Medical Pharmacology
23-260 CHS; Mail Code: 173517
University of California, Los Angeles
Los Angles, CA 90095

Department / Division Affiliations
Member, Jonsson Comprehensive Cancer Center
Assistant Professor, Molecular & Medical Pharmacology

Research Interests
My research resides in a highly cross-disciplinary field of BioMEMS, Cancer molecular diagnostics, therapeutics and Nanomedicine. Currently focusing on: 1) Develop multi-omics single cell tools for interrogating the heterogeneous tumor cells and immune cells at multiple bimolecular levels. 2) Information theoretical and computational approaches for dissecting the high-dimensional single cell data with a particular focus on resolving tumor heterogeneity and dynamics of the signal transduction network for anticipating therapy resistance and identifying effective combination therapies. 3) Isolation, molecular characterization, and neoantigen identification of rare tumor cells in body fluids for cancer diagnosis and immunotherapy.


Publications
Lidia Robert, Wei Wei*, Yapeng Su, Jennifer Tsoi, Min Xue, Angel Garcia-Diaz, Blanca Homet Moreno, Lu Sun, Willy Hugo, Jungwoo Kim, Rachel H.Y. Ng, Jihoon W. Lee, Xiangju Kong, Richard C. Koya, Begonya Comin-Anduix, Roger S. Lo, Thomas G. Graeber, James R. Heath*, Antoni Ribas* Kinetics of de-differentiation transition and adaptive resistance in melanomas mediated by continuous BRAF inhibition. Nature Communications ; in review (*: co-corresponding authors): .
Yao Lu, Liu Yang, Wei Wei*, Qihui Shi* Microchip-Based Single-Cell Functional Proteomics for Biomedical Applications. Lab on a Chip . ; in press (*: co-corresponding authors): .
Yin Tang, Zhuo Wang, Jungwoo Kim, Ziming Li, Yuliang Deng, Yan Li, James R. Heath, Wei Wei*, Shun Lu*, Qihui Shi* High Throughput Screening of Rare Metabolically Active Tumor Cells in Pleural Effusion and Peripheral Blood of Lung Cancer Patients. Proc. Natl. Acad. Sci. U.S.A. 2017; 114(10): 2544-2549 (*: co-corresponding authors).
Yapeng Su, Qihui Shi*, Wei Wei* Single Cell Proteomics in Biomedicine: High-dimensional Data Acquisition, Visualization and Analysis. Proteomics. 2017; 17(3-4): 1600267 (*:co-corresponding authors).
Wei Wei, Young Shik Shin, Min Xue, Tomoo Matsutani, Kenta Masui, Huijun Yang, Shiro Ikegami, Yuchao Gu, Hermann Ken, Dazy Johnson, Xiangming Ding, Kiwook Hwang, Jungwoo Kim, Jian Zhou, Yapeng Su, Xinmin Li, Bruno Bonetti, Rajesh Chopra, C. David James, Webster K. Cavenee, Timothy F. Cloughesy, Paul S. Michel, James R. Heath, Beatrice Gini Single cell phosphoproteomics resolves adaptive signaling dynamics and informs targeted combination therapy in glioblastoma. Cancer Cell. 2016; 29(4): 563-573.
Liu Yang, Zhihua Wang, Yuliang Deng, Yan Li*, Wei Wei*, Qihui Shi* Single-Cell, Multiplexed Protein Detection of Rare Tumor Cells Based on a Beads-on-Barcode Antibody Microarray. Analytical Chemistry. 2016; 88(22): 11077-11083 (*: co-corresponding authors).
Min Xue, Wei Wei, Yapeng Su, Dazy Johnson, James R. Heath Supramolecular Probes for Assessing Glutamine Uptake Enable Semi-Quantitative Metabolic Models in Single Cells. Journal of the American Chemical Society. 2016; 138(9): 3085–3093.
Min Xue*, Wei Wei*, Yapeng Su, Jungwoo Kim, Young Shik Shin, Wilson X. Mai, David A. Nathanson and James, R. Heath Chemical Methods for the Simultaneous Quantitation of Metabolitesand Proteins from Single Cells. Journal of the American Chemical Society. 2015; 137: 4066–-4069;*Equal Contribution.
Yu Zhang, Yin Tang, Shuai Sun, Zhihua Wang, Wenjun Wu, Xiaodong Zhao, Daniel M. Czajkowsky, Yan Li, Jianhui Tian, Ling Xu, Wei Wei, Yuliang Deng, and Qihui Shi Single-Cell Codetection of Metabolic Activity, Intracellular Functional Proteins, and Genetic Mutations from Rare Circulating Tumor Cells . Analytical Chemistry. 2015; 87(19): 9761-9768.
Yuliang Deng, Yu Zhang, Shuai Sun, Zhihua Wang, Minjiao Wang, Beiqin Yu, Daniel M. Czajkowsky, Bingya Liu, Yan Li, Wei Wei, Qihui Shi An Integrated Microfluidic Chip System for Single-Cell Secretion Profiling of Rare Circulating Tumor Cells. Scientific Reports. 2014; 4: 7499.
Yi Jing, Xinyu Bao, Wei Wei, Chun Li, Ke Sun, David P. R. Aplin, Yang Ding, Zhong-Lin Wang, Yoshio Bando, Deli Wang Catalyst-Free Heteroepitaxial MOCVD Growth of InAs Nanowires on Si Substrates. Journal of Physical Chemistry C. 2014; 118: 1696-1705.
Jing Yu, Jing Zhou, Alex Sutherland, Wei Wei, Young Shik Shin, Min Xue, James R Heath Microfluidics-Based Single-Cell Functional Proteomics for Fundamental and Applied Biomedical Applications. Annual Reviews of Analytical Chemistry. 2014; 7: 275-295.
Wei Wei, Qihui Shi, Francoise Remacle, Lidong Qin, David B Shackelford, Young Shik Shin, Paul S Mischel, RD Levine, James R Heath Hypoxia induces a phase transition within a kinase signaling network in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110: E1352-E1360.
Wei Wei, Young Shik Shin, Chao Ma, Jun Wang, Meltem Elitas, Rong Fan, James R Heath Microchip platforms for multiplex single-cell functional proteomics with applications to immunology and cancer research. Genome medicine. 2013; 5: 75.
Jun Wang, Douglas Tham, Wei Wei, Young Shik Shin, Chao Ma, Habib Ahmad, Qihui Shi, Jenkan Yu, Raphael D Levine, James R Heath Quantitating cell–cell interaction functions with applications to glioblastoma multiforme cancer cells. Nano Letters. 2012; 12: 6101–6106.
Qihui Shi, Lidong Qin, Wei Wei, Feng Geng, Rong Fan, Young Shik Shin, Deliang Guo, Leroy Hood, Paul S Mischel, James R Heath Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109: 419-424.
Tingbin Yang, Ke Sun, Xilan Liu, Wei Wei, Tianzhi Yu, Xiong Gong, Deli Wang, Yong Cao Zinc Oxide Nanowire As an Electron-Extraction Layer for Broadband Polymer Photodetectors with an Inverted Device Structure. The Journal of Physical Chemistry C. 2012; 116: 13650–13653.
Ke Sun*, Wei Wei*, Yong Ding, Yi Jing, Zhong Lin Wang, Deli Wang Crystalline ZnO thin film by hydrothermal growth. Chemical Communications. 2011; 47: 7776-7778;*Equal Contribution.
Young Shik Shin, Françoise Remacle, Rong Fan, Kiwook Hwang, Wei Wei, Habib Ahmad, RD Levine, James R Heath Protein signaling networks from single cell fluctuations and information theory profiling. Biophysical journal. 2011; 100: 2378-2386.
Wei Wei, Xin-Yu Bao, Cesare Soci, Yong Ding, Zhong-Lin Wang, Deli Wang Direct heteroepitaxy of vertical InAs nanowires on Si substrates for broad band photovoltaics and photodetection. Nano Letters. 2009; 8: 2926-2934.
Xin-Yu Bao, Cesare Soci, Darija Susac, Jon Bratvold, David PR Aplin, Wei Wei, Ching-Yang Chen, Shadi A Dayeh, Karen L Kavanagh, Deli Wang Heteroepitaxial growth of vertical GaAs nanowires on Si (111) substrates by metal− organic chemical vapor deposition. Nano Letters. 2008; 8: 3755–3760.
Yang Wei, Wei Wei, Liang Liu, Shoushan Fan Mounting multi-walled carbon nanotubes on probes by dielectrophoresis. Diamond and Related Materials. 2008; 17: 1877-1880.
Wei Wei, Yang Liu, Yang Wei, Kaili Jiang, Lian-Mao Peng, Shoushan Fan Tip cooling effect and failure mechanism of field-emitting carbon nanotubes. Nano Letters. 2007; 7: 64-68.
Wei Wei, Kaili Jiang, Yang Wei, Peng Liu, Kai Liu, Lina Zhang, Qunqing Li, Shoushan Fan LaB 6 tip-modified multiwalled carbon nanotube as high quality field emission electron source. Applied Physics Letters. 2006; 89: 203112.
Wei Wei, Kaili Jiang, Yang Wei, Ming Liu, Haitao Yang, Lina Zhang, Qunqing Li, Liang Liu, Shoushan Fan Measuring the stress in field-emitting carbon nanotubes. Nanotechnology. 2006; 17: 1994-1998.