FACULTY RESEARCH

Faculty List

Jide Tian, M.D.

Work Email Address: jtian@mednet.ucla.edu

Office Phone Number: 310-206-3350

Mailing Address:
10833 Le Conte Ave.
Los Angeles, CA 90095

Department / Division Affiliations
Member, Immunity, Microbes & Molecular Pathogenesis GPB Home Area, Molecular Pharmacology GPB Home Area
Adjunct Professor, Molecular & Medical Pharmacology

Research Interests
My research focuses on the molecular mechanism(s), which establish peripheral T cell tolerance, the interaction between T cell and antigen presenting cells, and neuroimmune regulation. Using autoimmune disease murine models, my current investigations are 1) to characterize autoimmune processes; 2) to develop antigen based immunotherapies to re-establish self tolerance; and 3) to characterize lymphocytic GABA receptors and the potential immuno-regulatory function of GABA.

These studies will aid future endeavors to design immunotherapies for autoimmune and inflammatory diseases.



Publications
Washburn Lorraine R, Zekzer Dan, Eitan Shoshana, Lu Yuxin, Dang Hoa, Middleton Blake, Evans Christopher J, Tian Jide, Kaufman Daniel L A potential role for shed soluble major histocompatibility class I molecules as modulators of neurite outgrowth. PloS one. 2011; 6(3): e18439.
Yong Jing, Lacan Goran, Dang Hoa, Hsieh Terry, Middleton Blake, Wasserfall Clive, Tian Jide, Melega William P, Kaufman Daniel L BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease. PloS one. 2011; 6(1): e16610.
Tian Jide, Dang Hoa, Kaufman Daniel L Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD mice. PloS one. 2011; 6(9): e25337.
Wu Zhongqi-Phyllis, Washburn Lorraine, Bilousova Tina V, Boudzinskaia Maia, Escande-Beillard Nathalie, Querubin Jyes, Dang Hoa, Xie Cui-Wei, Tian Jide, Kaufman Daniel L Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair. Journal of neuroimmunology. 2011; 232(1-2): 8-16.
Wu Zhongqi-Phyllis, Bilousova Tina, Escande-Beillard Nathalie, Dang Hoa, Hsieh Terry, Tian Jide, Kaufman Daniel L Major histocompatibility complex class I-mediated inhibition of neurite outgrowth from peripheral nerves. Immunology letters. 2011; 135(1-2): 118-23.
Yong Jing, Rasooly Julia, Dang Hoa, Lu Yuxin, Middleton Blake, Zhang Zesong, Hon Larry, Namavari Mohammad, Stout David B, Atkinson Mark A, Tian Jide, Gambhir Sanjiv Sam, Kaufman Daniel L Multimodality imaging of β-cells in mouse models of type 1 and 2 diabetes. Diabetes. 2011; 60(5): 1383-92.
Ling Yong, Ye Xiaolei, Zhang Zhenzhen, Zhang Yihua, Lai Yisheng, Ji Hui, Peng Sixun, Tian Jide Novel nitric oxide-releasing derivatives of farnesylthiosalicylic acid: synthesis and evaluation of antihepatocellular carcinoma activity. Journal of medicinal chemistry. 2011; 54(9): 3251-9.
Tian Jide, Yong Jing, Dang Hoa, Kaufman Daniel L Oral GABA treatment downregulates inflammatory responses in a mouse model of rheumatoid arthritis. Autoimmunity. 2011; 44(6): 465-70.
Tian Jide, Dang Hoa N, Yong Jing, Chui Wing-Sheung, Dizon Matthew P G, Yaw Catherine K Y, Kaufman Daniel L Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice. PloS one. 2011; 6(9): e25338.
Escande-Beillard Nathalie, Washburn Lorraine, Zekzer Dan, Wu Zhongqi-Phyllis, Eitan Shoshy, Ivkovic Sonja, Lu Yuxin, Dang Hoa, Middleton Blake, Bilousova Tina V, Yoshimura Yoshitaka, Evans Christopher J, Joyce Sebastian, Tian Jide, Kaufman Daniel L Neurons preferentially respond to self-MHC class I allele products regardless of peptide presented. Journal of immunology (Baltimore, Md. : 1950). 2010; 184(2): 816-23.
Huang Zhangjian, Zhang Yihua, Zhao Li, Jing Yongwang, Lai Yisheng, Zhang Luyong, Guo Qinglong, Yuan Shengtao, Zhang Jianjun, Chen Li, Peng Sixun, Tian Jide Synthesis and anti-human hepatocellular carcinoma activity of new nitric oxide-releasing glycosyl derivatives of oleanolic acid. Organic & biomolecular chemistry. 2010; 8(3): 632-9.
Lai Yisheng, Ma Lin, Huang Wenxing, Yu Xing, Zhang Yihua, Ji Hui, Tian Jide Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors. Bioorganic & medicinal chemistry letters. 2010; 20(24): 7349-53.
Lai Yisheng, Shen Lihong, Zhang Zhenzhen, Liu Wenqing, Zhang Yihua, Ji Hui, Tian Jide Synthesis and biological evaluation of furoxan-based nitric oxide-releasing derivatives of glycyrrhetinic acid as anti-hepatocellular carcinoma agents. Bioorganic & medicinal chemistry letters. 2010; 20(22): 6416-20.
Ling Yong, Ye Xiaolei, Ji Hui, Zhang Yihua, Lai Yisheng, Peng Sixun, Tian Jide Synthesis and evaluation of nitric oxide-releasing derivatives of farnesylthiosalicylic acid as anti-tumor agents. Bioorganic & medicinal chemistry. 2010; 18(10): 3448-56.
Tian Jide, Kaufman Daniel L Antigen-based therapy for the treatment of type 1 diabetes. Diabetes. 2009; 58(9): 1939-46.
Tian Jide, Dang Hoa, von Boehmer Harald, Jaeckel Elmar, Kaufman Daniel L Transgenically induced GAD tolerance curtails the development of early beta-cell autoreactivities but causes the subsequent development of supernormal autoreactivities to other beta-cell antigens. Diabetes. 2009; 58(12): 2843-50.
Chen Li, Zhang Yihua, Kong Xiangwen, Lan Edward, Huang Zhangjian, Peng Sixun, Kaufman Daniel L, Tian Jide Design, synthesis, and antihepatocellular carcinoma activity of nitric oxide releasing derivatives of oleanolic acid. Journal of medicinal chemistry. 2008; 51(15): 4834-8.
Chen Li, Zhang Yihua, Kong Xiangwen, Peng Sixun, Tian Jide Synthesis and biological evaluation of nitric oxide-releasing derivatives of oleanolic acid as inhibitors of HepG2 cell apoptosis. Bioorganic & medicinal chemistry letters. 2007; 17(11): 2979-82.
Li Yong-Qi, Ji Hui, Zhang Yi-Hua, Shi Wei-Bing, Meng Zhao-Ke, Chen Xiu-Ying, Du Guan-Tao, Tian Jide WB1106, a novel nitric oxide-releasing derivative of telmisartan, inhibits hypertension and improves glucose metabolism in rats. European journal of pharmacology. 2007; 577(1-3): 100-8.
Tian Jide, Zekzer Dan, Lu Yuxin, Dang Hoa, Kaufman Daniel L B cells are crucial for determinant spreading of T cell autoimmunity among beta cell antigens in diabetes-prone nonobese diabetic mice. Journal of immunology (Baltimore, Md. : 1950). 2006; 176(4): 2654-61.
Lu Yuxin, Dang Hoa, Middleton Blake, Campbell-Thompson Martha, Atkinson Mark A, Gambhir Sanjiv Sam, Tian Jide, Kaufman Daniel L Long-term monitoring of transplanted islets using positron emission tomography. Molecular therapy : the journal of the American Society of Gene Therapy. 2006; 14(6): 851-6.
Lu Yuxin, Dang Hoa, Middleton Blake, Zhang Zesong, Washburn Lorraine, Stout David B, Campbell-Thompson Martha, Atkinson Mark A, Phelps Michael, Gambhir Sanjiv Sam, Tian Jide, Kaufman Daniel L Noninvasive imaging of islet grafts using positron-emission tomography. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103(30): 11294-9.
Stiles Bangyan L, Kuralwalla-Martinez Christine, Guo Wei, Gregorian Caroline, Wang Ying, Tian Jide, Magnuson Mark A, Wu Hong Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Molecular and cellular biology. 2006; 26(7): 2772-81.
Olcott Angelica P, Tian Jide, Walker Valerie, Dang Hoa, Middleton Blake, Adorini Luciano, Washburn Lorraine, Kaufman Daniel L Antigen-based therapies using ignored determinants of beta cell antigens can more effectively inhibit late-stage autoimmune disease in diabetes-prone mice. Journal of immunology (Baltimore, Md. : 1950). 2005; 175(3): 1991-9.
Olcott Angelica P, Tocco Georges, Tian Jide, Zekzer Dan, Fukuto Jon, Ignarro Louis, Kaufman Daniel L A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet allograft rejection. Diabetes. 2004; 53(10): 2574-80.
Lu Yuxin, Dang Hoa, Middleton Blake, Zhang Zesong, Washburn Lorraine, Campbell-Thompson Martha, Atkinson Mark A, Gambhir Sanjiv Sam, Tian Jide, Kaufman Daniel L Bioluminescent monitoring of islet graft survival after transplantation. Molecular therapy : the journal of the American Society of Gene Therapy. 2004; 9(3): 428-35.
Tian Jide, Lu Yuxin, Zhang Hanwei, Chau Cindy H, Dang Hoa N, Kaufman Daniel L Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model. Journal of immunology (Baltimore, Md. : 1950). 2004; 173(8): 5298-304.
Tian, J Lu, Y Hanssen, L Dang, H Kaufman, DL Memory and effector T cells modulate subsequently primed immune responses to unrelated antigens. Cellular immunology. . 2003; 224(2): 74-85.
Tian, J Olcott, AP Kaufman, DL Antigen-based immunotherapy drives the precocious development of autoimmunity. Journal of immunology (Baltimore, Md. : 1950) . 2002; 169(11): 6564-9.
Tian, J Zekzer, D Hanssen, L Lu, Y Olcott, A Kaufman, DL Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. Journal of immunology (Baltimore, Md. : 1950) . 2001; 167(2): 1081-9.
Tian, J Gregori, S Adorini, L Kaufman, DL The frequency of high avidity T cells determines the hierarchy of determinant spreading. Journal of immunology (Baltimore, Md. : 1950) . 2001; 166(12): 7144-50.
Tian J., and Kaufman D. Attenuation of inducible Th2 immunity with autoimmune diasease progression. J. Immunology 1998; 161: 5399-5403.
Tian, J Chau, C Kaufman, DL Insulin selectively primes Th2 responses and induces regulatory tolerance to insulin in pre-diabetic mice. Diabetologia. . 1998; 41(2): 237-40.
Tian, J Lehmann, PV Kaufman, DL Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens. The Journal of experimental medicine. . 1997; 186(12): 2039-43.
Tian J., Clare-Salzler M., Herschenfeld A., Middleton B., Newman D., Mueller R., Arita S., Evans C., Atkinson M., Mullen Y., Sarvetnick N., Tobin A., Lehmann P., Kaufman D Modulating autoimmune response to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nature Medicine 1996; 2: 1348-1353.
Tian, J Atkinson, MA Clare-Salzler, M Herschenfeld, A Forsthuber, T Lehmann, PV Kaufman, DL Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. The Journal of experimental medicine. . 1996; 183(4): 1561-7.
Kaufman D., Keith D., Anton B., Tian J., Magendo K., Newman D., Tran T., Lee D, Wen C., Xia Y., Lusis Y., and Evans C. Characterization of the murine m opioid receptor gene. J. Bio-Chem 1995; 270: 15877-15883.
Tian J., Lehmann P., and Kaufman D. Cross-reactive T cell recognition of a sequence similarity region between Coxsackievirus and glutamate decaroxylase is associated with a murine diabetes susceptibility allele. J. Exp. Med 1994; 180: 1979-1984 .
Lee, DS Tian, J Phan, T Kaufman, DL Cloning and sequence analysis of a murine cDNA encoding glutamate decarboxylase (GAD65). Biochimica et biophysica acta. . 1993; 1216(1): 157-60.
Kaufman D., Clare-Salzler M., Tian J., Forsthuber T., Ting G., RobinsonP., AtkinsonM., Sercarz E., Tobin A., and Lehmann P Spontaneous loss of T cell tolerance to glutamate decarboxylatase in murine insulin-dependent diabetes.. Nature 1993; 365: 69-72 .