FACULTY RESEARCH

Faculty List

Edythe D. London, Ph.D.

Work Email Address: elondon@mednet.ucla.edu

Fax Number: (310) 825-0812

Lab Number: (310) 825-0606

Laboratory of Molecular Neuroimaging

Office Address:
760 Westwood Plaza
Los Angeles, CA 90095

Work Address:
NPI
Los Angeles, CA 90095

Department / Division Affiliations
Professor In-Residence, Psychiatry and Biobehavioral Sciences, Molecular & Medical Pharmacology
Member, Brain Research Institute, CTSI, Molecular Pharmacology GPB Home Area, Neuroscience GPB Home Area

Research Interests
The projects in my laboratory focus on the neurobiology of substance abuse and development of new probes for the study of brain function by external imaging. Using positron emission tomography (PET) scanning and magnetic resonance imaging, our current projects concern dependence on methamphetamine and nicotine. The questions that we are asking in our human research relate to the links between genetics, cognitive function, affect and vulnerability to drug abuse and the maintenance of dependence. Correlative studies in animal models of addiction will relate altered neuronal function with gene expression, as affected by drug treatments. The goal is to develop a better understanding of the neurobiology of addiction, using a translational approach toward rational design of therapeutics.


Publications
Morales, A. M.; Ghahremani, D.; Kohno, M.; Hellemann, G. S.; London, E. D. Cigarette exposure, dependence, and craving are related to insula thickness in young adult smokers. Neuropsychopharmacology. 2014; 39(8): 1816-22.
White, C. N.; Congdon, E.; Mumford, J. A.; Karlsgodt, K. H.; Sabb, F. W.; Freimer, N. B.; London, E. D.; Cannon, T. D.; Bilder, R. M.; Poldrack, R. A. Decomposing Decision Components in the Stop-signal Task: A Model-based Approach to Individual Differences in Inhibitory Control. J Cogn Neurosci. 2014; 26(8): 1601-14.
Ivanov, I.; Liu, X.; Clerkin, S.; Schulz, K.; Fan, J.; Friston, K.; London, E. D.; Schwartz, J.; Newcorn, J. H. Methylphenidate and brain activity in a reward/conflict paradigm: role of the insula in task performance. Eur Neuropsychopharmacol. 2014; 24(6): 897-906.
Congdon, E.; Altshuler, L. L.; Mumford, J. A.; Karlsgodt, K. H.; Sabb, F. W.; Ventura, J.; McGough, J. J.; London, E. D.; Cannon, T. D.; Bilder, R. M.; Poldrack, R. A. Neural activation during response inhibition in adult attention-deficit/hyperactivity disorder: preliminary findings on the effects of medication and symptom severity. Psychiatry Res. 2014; 222(1-2): 17-28.
Helfinstein, S. M.; Schonberg, T.; Congdon, E.; Karlsgodt, K. H.; Mumford, J. A.; Sabb, F. W.; Cannon, T. D.; London, E. D.; Bilder, R. M.; Poldrack, R. A. Predicting risky choices from brain activity patterns. Proc Natl Acad Sci U S A. 2014; 111(7): 2470-5.
Kohno, M.; Morales, A. M.; Ghahremani, D. G.; Hellemann, G.; London, E. D. Risky decision making, prefrontal cortex, and mesocorticolimbic functional connectivity in methamphetamine dependence. JAMA Psychiatry. 2014; 71(7): 812-20.
O'Neill, J.; Tobias, M. C.; Hudkins, M.; Oh, E. Y.; Hellemann, G. S.; Nurmi, E. L.; London, E. D. Thalamic glutamate decreases with cigarette smoking. Psychopharmacology (Berl). 2014; 231(13): 2717-24.
Courtney, K. E.; Ghahremani, D. G.; London, E. D.; Ray, L. A. The association between cue-reactivity in the precuneus and level of dependence on nicotine and alcohol. Drug Alcohol Depend. 2014; 141: 21-6.
Ray, L. A.; Courtney, K. E.; Ghahremani, D. G.; Miotto, K.; Brody, A.; London, E. D. Varenicline, low dose naltrexone, and their combination for heavy-drinking smokers: human laboratory findings. Psychopharmacology (Berl). 2014; .
Berman, S. M.; Paz-Filho, G.; Wong, M. L.; Kohno, M.; Licinio, J.; London, E. D. Effects of leptin deficiency and replacement on cerebellar response to food-related cues. Cerebellum. 2013; 12(1): 59-67.
Ghahremani, D. G.; Oh, E. Y.; Dean, A. C.; Mouzakis, K.; Wilson, K. D.; London, E. D. Effects of the Youth Empowerment Seminar on impulsive behavior in adolescents. J Adolesc Health. 2013; 53(1): 139-41.
Berman, S. M.; London, E. D.; Morgan, M.; Rapkin, A. J. Elevated gray matter volume of the emotional cerebellum in women with premenstrual dysphoric disorder. J Affect Disord. 2013; 146(2): 266-71.
Galvan, A.; Schonberg, T.; Mumford, J.; Kohno, M.; Poldrack, R. A.; London, E. D. Greater risk sensitivity of dorsolateral prefrontal cortex in young smokers than in nonsmokers. Psychopharmacology (Berl). 2013; 229(2): 345-55.
Groman, S. M.; Morales, A. M.; Lee, B.; London, E. D.; Jentsch, J. D. Methamphetamine-induced increases in putamen gray matter associate with inhibitory control. Psychopharmacology (Berl). 2013; 229(3): 527-38.
Kohno, M.; Ghahremani, D. G.; Morales, A. M.; Robertson, C. L.; Ishibashi, K.; Morgan, A. T.; Mandelkern, M. A.; London, E. D. Risk-Taking Behavior: Dopamine D2/D3 Receptors, Feedback, and Frontolimbic Activity. Cereb Cortex. 2013; .
Reise, S. P.; Moore, T. M.; Sabb, F. W.; Brown, A. K.; London, E. D. The Barratt Impulsiveness Scale-11: reassessment of its structure in a community sample. Psychol Assess. 2013; 25(2): 631-42.
Ishibashi, K.; Robertson, C. L.; Mandelkern, M. A.; Morgan, A. T.; London, E. D. The simplified reference tissue model with 18F-fallypride positron emission tomography: choice of reference region. Mol Imaging. 2013; 12(8): .
Canamar, C. P.; London, E. Acute cigarette smoking reduces latencies on a Smoking Stroop test. Addict Behav. 2012; 37(5): 627-31.
Hudkins, M.; O'Neill, J.; Tobias, M. C.; Bartzokis, G.; London, E. D. Cigarette smoking and white matter microstructure. Psychopharmacology (Berl). 2012; 221(2): 285-95.
Ishibashi, K.; Berman, S. M.; Paz-Filho, G.; Lee, B.; Robertson, C.; Mandelkern, M. A.; Wong, M. L.; Licinio, J.; London, E. D. Dopamine D2/D3 receptor availability in genetically leptin-deficient patients after long-term leptin replacement. Mol Psychiatry. 2012; 17(4): 352-3.
Groman, S. M.; Lee, B.; Seu, E.; James, A. S.; Feiler, K.; Mandelkern, M. A.; London, E. D.; Jentsch, J. D. Dysregulation of D(2)-mediated dopamine transmission in monkeys after chronic escalating methamphetamine exposure. J Neurosci. 2012; 32(17): 5843-52.
Dean, A. C.; Hellemann, G.; Sugar, C. A.; London, E. D. Educational attainment is not a good proxy for cognitive function in methamphetamine dependence. Drug Alcohol Depend. 2012; 123(1-3): 249-54.
Payer, D. E.; Nurmi, E. L.; Wilson, S. A.; McCracken, J. T.; London, E. D. Effects of methamphetamine abuse and serotonin transporter gene variants on aggression and emotion-processing neurocircuitry. Transl Psychiatry. 2012; 2: e80.
Morales, A. M.; Lee, B.; Hellemann, G.; O'Neill, J.; London, E. D. Gray-matter volume in methamphetamine dependence: cigarette smoking and changes with abstinence from methamphetamine. Drug Alcohol Depend. 2012; 125(3): 230-8.
Zorick, T.; Lee, B.; Mandelkern, M. A.; Fong, T.; Robertson, C.; Ghahremani, D. G.; Brown, A. K.; Sumerel, B.; London, E. D. Low striatal dopamine receptor availability linked to caloric intake during abstinence from chronic methamphetamine abuse. Mol Psychiatry. 2012; 17(6): 569-71.
Payer, D. E.; Baicy, K.; Lieberman, M. D.; London, E. D. Overlapping neural substrates between intentional and incidental down-regulation of negative emotions. Emotion. 2012; 12(2): 229-35.
Brown, A. K.; Mandelkern, M. A.; Farahi, J.; Robertson, C.; Ghahremani, D. G.; Sumerel, B.; Moallem, N.; London, E. D. Sex differences in striatal dopamine D2/D3 receptor availability in smokers and non-smokers. Int J Neuropsychopharmacol. 2012; 15(7): 989-94.
Ghahremani, D. G.; Lee, B.; Robertson, C. L.; Tabibnia, G.; Morgan, A. T.; De Shetler, N.; Brown, A. K.; Monterosso, J. R.; Aron, A. R.; Mandelkern, M. A.; Poldrack, R. A.; London, E. D. Striatal dopamine D(2)/D(3) receptors mediate response inhibition and related activity in frontostriatal neural circuitry in humans. J Neurosci. 2012; 32(21): 7316-24.
Dean, A. C.; Sevak, R. J.; Monterosso, J. R.; Hellemann, G.; Sugar, C. A.; London, E. D. Acute modafinil effects on attention and inhibitory control in methamphetamine-dependent humans. J Stud Alcohol Drugs. 2011; 72(6): 943-53.
Tabibnia, G.; Monterosso, J. R.; Baicy, K.; Aron, A. R.; Poldrack, R. A.; Chakrapani, S.; Lee, B.; London, E. D. Different forms of self-control share a neurocognitive substrate. J Neurosci. 2011; 31(13): 4805-10.
Groman, S. M.; Lee, B.; London, E. D.; Mandelkern, M. A.; James, A. S.; Feiler, K.; Rivera, R.; Dahlbom, M.; Sossi, V.; Vandervoort, E.; Jentsch, J. D. Dorsal striatal D2-like receptor availability covaries with sensitivity to positive reinforcement during discrimination learning. J Neurosci. 2011; 31(20): 7291-9.
Ghahremani, D. G.; Tabibnia, G.; Monterosso, J.; Hellemann, G.; Poldrack, R. A.; London, E. D. Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals. Neuropsychopharmacology. 2011; 36(5): 950-9.
Brody, A. L.; Mandelkern, M. A.; London, E. D.; Khan, A.; Kozman, D.; Costello, M. R.; Vellios, E. E.; Archie, M. M.; Bascom, R.; Mukhin, A. G. Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain. Arch Gen Psychiatry. 2011; 68(9): 953-60.
Zorick, T.; Mandelkern, M. A.; Lee, B.; Wong, M. L.; Miotto, K.; Shabazian, J.; London, E. D. Elevated plasma prolactin in abstinent methamphetamine-dependent subjects. Am J Drug Alcohol Abuse. 2011; 37(1): 62-7.
Dean, A. C.; Sugar, C. A.; Hellemann, G.; London, E. D. Is all risk bad? Young adult cigarette smokers fail to take adaptive risk in a laboratory decision-making test. Psychopharmacology (Berl). 2011; 215(4): 801-11.
Payer, D. E.; Lieberman, M. D.; London, E. D. Neural correlates of affect processing and aggression in methamphetamine dependence. Arch Gen Psychiatry. 2011; 68(3): 271-82.
Galvan, A.; Poldrack, R. A.; Baker, C. M.; McGlennen, K. M.; London, E. D. Neural correlates of response inhibition and cigarette smoking in late adolescence. Neuropsychopharmacology. 2011; 36(5): 970-8.
Rapkin, A. J.; Berman, S. M.; Mandelkern, M. A.; Silverman, D. H.; Morgan, M.; London, E. D. Neuroimaging evidence of cerebellar involvement in premenstrual dysphoric disorder. Biol Psychiatry. 2011; 69(4): 374-80.
Zorick, T.; Sugar, C. A.; Hellemann, G.; Shoptaw, S.; London, E. D. Poor response to sertraline in methamphetamine dependence is associated with sustained craving for methamphetamine. Drug Alcohol Depend. 2011; 118(2-3): 500-3.
Nestor, L. J.; Ghahremani, D. G.; Monterosso, J.; London, E. D. Prefrontal hypoactivation during cognitive control in early abstinent methamphetamine-dependent subjects. Psychiatry Res. 2011; 194(3): 287-95.
London, E. D.; Berman, S. M.; Chakrapani, S.; Delibasi, T.; Monterosso, J.; Erol, H. K.; Paz-Filho, G.; Wong, M. L.; Licinio, J. Short-term plasticity of gray matter associated with leptin deficiency and replacement. J Clin Endocrinol Metab. 2011; 96(8): E1212-20.
Simon, S. L.; Dean, A. C.; Cordova, X.; Monterosso, J. R.; London, E. D. Methamphetamine dependence and neuropsychological functioning: evaluating change during early abstinence. J Stud Alcohol Drugs. 2010; 71(3): 335-44.
Bauer, M.; Berman, S. M.; Schlagenhauf, F.; Voytek, B.; Rasgon, N.; Mandelkern, M. A.; Whybrow, P. C.; London, E. D. Regional cerebral glucose metabolism and anxiety symptoms in bipolar depression: effects of levothyroxine. Psychiatry Res. 2010; 181(1): 71-6.
Azizian, A.; Nestor, L. J.; Payer, D.; Monterosso, J. R.; Brody, A. L.; London, E. D. Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task. Neuropsychopharmacology. 2010; 35(3): 775-82.
Tobias, M. C.; O'Neill, J.; Hudkins, M.; Bartzokis, G.; Dean, A. C.; London, E. D. White-matter abnormalities in brain during early abstinence from methamphetamine abuse. Psychopharmacology (Berl). 2010; 209(1): 13-24.
Zorick, T.; Nestor, L.; Miotto, K.; Sugar, C.; Hellemann, G.; Scanlon, G.; Rawson, R.; London, E. D. Withdrawal symptoms in abstinent methamphetamine-dependent subjects. Addiction. 2010; 105(10): 1809-18.
Brody, A. L.; Olmstead, R. E.; Abrams, A. L.; Costello, M. R.; Khan, A.; Kozman, D.; Saxena, S.; Farahi, J.; London, E. D.; Mandelkern, M. A. Effect of a history of major depressive disorder on smoking-induced dopamine release. Biol Psychiatry. 2009; 66(9): 898-901.
London, E. D.; Berman, S. M.; Mohammadian, P.; Ritchie, T.; Mandelkern, M. A.; Susselman, M. K.; Schlagenhauf, F.; Noble, E. P. Effect of the TaqIA polymorphism on ethanol response in the brain. Psychiatry Res. 2009; 174(3): 163-70.
Berman, S. M.; Noble, E. P.; Mohammadian, P.; Ritchie, T.; Mandelkern, M. A.; London, E. D. Laterality of cortical response to ethanol is moderated by TaqIA A1 allele. Synapse. 2009; 63(9): 817-21.
Zorick, T.; Sevak, R. J.; Miotto, K.; Shoptaw, S.; Swanson, A. N.; Clement, C.; De La Garza, R., 2nd; Newton, T. F.; London, E. D. Pilot Safety Evaluation of Varenicline for the Treatment of Methamphetamine Dependence. J Exp Pharmacol. 2009; 2010(2): 13-18.
Saxena, S.; Gorbis, E.; O'Neill, J.; Baker, S. K.; Mandelkern, M. A.; Maidment, K. M.; Chang, S.; Salamon, N.; Brody, A. L.; Schwartz, J. M.; London, E. D. Rapid effects of brief intensive cognitive-behavioral therapy on brain glucose metabolism in obsessive-compulsive disorder. Mol Psychiatry. 2009; 14(2): 197-205.
Lee, B.; London, E. D.; Poldrack, R. A.; Farahi, J.; Nacca, A.; Monterosso, J. R.; Mumford, J. A.; Bokarius, A. V.; Dahlbom, M.; Mukherjee, J.; Bilder, R. M.; Brody, A. L.; Mandelkern, M. A. Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity. J Neurosci. 2009; 29(47): 14734-40.
Brody, A. L.; Mandelkern, M. A.; Olmstead, R. E.; Allen-Martinez, Z.; Scheibal, D.; Abrams, A. L.; Costello, M. R.; Farahi, J.; Saxena, S.; Monterosso, J.; London, E. D. Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette. Neuropsychopharmacology. 2009; 34(2): 282-9.
Berman, S. M.; Voytek, B.; Mandelkern, M. A.; Hassid, B. D.; Isaacson, A.; Monterosso, J.; Miotto, K.; Ling, W.; London, E. D. Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse. Mol Psychiatry. 2008; 13(9): 897-908.
Payer, D. E.; Lieberman, M. D.; Monterosso, J. R.; Xu, J.; Fong, T. W.; London, E. D. Differences in cortical activity between methamphetamine-dependent and healthy individuals performing a facial affect matching task. Drug Alcohol Depend. 2008; 93(1-2): 93-102.
Xu, J.; Azizian, A.; Monterosso, J.; Domier, C. P.; Brody, A. L.; Fong, T. W.; London, E. D. Gender effects on mood and cigarette craving during early abstinence and resumption of smoking. Nicotine Tob Res. 2008; 10(11): 1653-61.
Azizian, A.; Monterosso, J. R.; Brody, A. L.; Simon, S. L.; London, E. D. Severity of nicotine dependence moderates performance on perceptual-motor tests of attention. Nicotine Tob Res. 2008; 10(4): 599-606.
Galynker,, II; Eisenberg, D.; Matochik, J. A.; Gertmenian-King, E.; Cohen, L.; Kimes, A. S.; Contoreggi, C.; Kurian, V.; Ernst, M.; Rosenthal, R. N.; Prosser, J.; London, E. D. Cerebral metabolism and mood in remitted opiate dependence. Drug Alcohol Depend. 2007; 90(2-3): 166-74.
Lee, B.; Groman, S.; London, E. D.; Jentsch, J. D. Dopamine D2/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys. Neuropsychopharmacology. 2007; 32(10): 2125-34.
Xu, J.; Mendrek, A.; Cohen, M. S.; Monterosso, J.; Simon, S.; Jarvik, M.; Olmstead, R.; Brody, A. L.; Ernst, M.; London, E. D. Effect of cigarette smoking on prefrontal cortical function in nondeprived smokers performing the Stroop Task. Neuropsychopharmacology. 2007; 32(6): 1421-8.
Domier, C. P.; Monterosso, J. R.; Brody, A. L.; Simon, S. L.; Mendrek, A.; Olmstead, R.; Jarvik, M. E.; Cohen, M. S.; London, E. D. Effects of cigarette smoking and abstinence on Stroop task performance. Psychopharmacology (Berl). 2007; 195(1): 1-9.
Monterosso, J. R.; Ainslie, G.; Xu, J.; Cordova, X.; Domier, C. P.; London, E. D. Frontoparietal cortical activity of methamphetamine-dependent and comparison subjects performing a delay discounting task. Hum Brain Mapp. 2007; 28(5): 383-93.
Baicy, K.; London, E. D.; Monterosso, J.; Wong, M. L.; Delibasi, T.; Sharma, A.; Licinio, J. Leptin replacement alters brain response to food cues in genetically leptin-deficient adults. Proc Natl Acad Sci U S A. 2007; 104(46): 18276-9.
Brody, A. L.; Mandelkern, M. A.; Olmstead, R. E.; Jou, J.; Tiongson, E.; Allen, V.; Scheibal, D.; London, E. D.; Monterosso, J. R.; Tiffany, S. T.; Korb, A.; Gan, J. J.; Cohen, M. S. Neural substrates of resisting craving during cigarette cue exposure. Biol Psychiatry. 2007; 62(6): 642-51.
Ernst, M.; Luckenbaugh, D. A.; Moolchan, E. T.; Leff, M. K.; Allen, R.; Eshel, N.; London, E. D.; Kimes, A. Behavioral predictors of substance-use initiation in adolescents with and without attention-deficit/hyperactivity disorder. Pediatrics. 2006; 117(6): 2030-9.
Xu, J.; Mendrek, A.; Cohen, M. S.; Monterosso, J.; Simon, S.; Brody, A. L.; Jarvik, M.; Rodriguez, P.; Ernst, M.; London, E. D. Effects of acute smoking on brain activity vary with abstinence in smokers performing the N-Back task: a preliminary study. Psychiatry Res. 2006; 148(2-3): 103-9.
Staley, J. K.; Krishnan-Sarin, S.; Cosgrove, K. P.; Krantzler, E.; Frohlich, E.; Perry, E.; Dubin, J. A.; Estok, K.; Brenner, E.; Baldwin, R. M.; Tamagnan, G. D.; Seibyl, J. P.; Jatlow, P.; Picciotto, M. R.; London, E. D.; O'Malley, S.; van Dyck, C. H. Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers. J Neurosci. 2006; 26(34): 8707-14.
Wong, D. F.; Kuwabara, H.; Schretlen, D. J.; Bonson, K. R.; Zhou, Y.; Nandi, A.; Brasic, J. R.; Kimes, A. S.; Maris, M. A.; Kumar, A.; Contoreggi, C.; Links, J.; Ernst, M.; Rousset, O.; Zukin, S.; Grace, A. A.; Lee, J. S.; Rohde, C.; Jasinski, D. R.; Gjedde, A.; London, E. D. Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving. Neuropsychopharmacology. 2006; 31(12): 2716-27.
Mendrek, A.; Monterosso, J.; Simon, S. L.; Jarvik, M.; Brody, A.; Olmstead, R.; Domier, C. P.; Cohen, M. S.; Ernst, M.; London, E. D. Working memory in cigarette smokers: comparison to non-smokers and effects of abstinence. Addict Behav. 2006; 31(5): 833-44.
Xu, J.; Mendrek, A.; Cohen, M. S.; Monterosso, J.; Rodriguez, P.; Simon, S. L.; Brody, A.; Jarvik, M.; Domier, C. P.; Olmstead, R.; Ernst, M.; London, E. D. Brain activity in cigarette smokers performing a working memory task: effect of smoking abstinence. Biol Psychiatry. 2005; 58(2): 143-50.
London, E. D.; Berman, S. M.; Voytek, B.; Simon, S. L.; Mandelkern, M. A.; Monterosso, J.; Thompson, P. M.; Brody, A. L.; Geaga, J. A.; Hong, M. S.; Hayashi, K. M.; Rawson, R. A.; Ling, W. Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers. Biol Psychiatry. 2005; 58(10): 770-8.
Monterosso, J. R.; Aron, A. R.; Cordova, X.; Xu, J.; London, E. D. Deficits in response inhibition associated with chronic methamphetamine abuse. Drug Alcohol Depend. 2005; 79(2): 273-7.
Brody, A. L.; Mandelkern, M. A.; Jarvik, M. E.; Lee, G. S.; Smith, E. C.; Huang, J. C.; Bota, R. G.; Bartzokis, G.; London, E. D. Differences between smokers and nonsmokers in regional gray matter volumes and densities. Biol Psychiatry. 2004; 55(1): 77-84.
Rotheram-Fuller, E.; Shoptaw, S.; Berman, S. M.; London, E. D. Impaired performance in a test of decision-making by opiate-dependent tobacco smokers. Drug Alcohol Depend. 2004; 73(1): 79-86.
London, E. D.; Simon, S. L.; Berman, S. M.; Mandelkern, M. A.; Lichtman, A. M.; Bramen, J.; Shinn, A. K.; Miotto, K.; Learn, J.; Dong, Y.; Matochik, J. A.; Kurian, V.; Newton, T.; Woods, R.; Rawson, R.; Ling, W. Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers. Arch Gen Psychiatry. 2004; 61(1): 73-84.
Bolla, K.; Ernst, M.; Kiehl, K.; Mouratidis, M.; Eldreth, D.; Contoreggi, C.; Matochik, J.; Kurian, V.; Cadet, J.; Kimes, A.; Funderburk, F.; London, E. Prefrontal cortical dysfunction in abstinent cocaine abusers. J Neuropsychiatry Clin Neurosci. 2004; 16(4): 456-64.
Brody, A. L.; Olmstead, R. E.; London, E. D.; Farahi, J.; Meyer, J. H.; Grossman, P.; Lee, G. S.; Huang, J.; Hahn, E. L.; Mandelkern, M. A. Smoking-induced ventral striatum dopamine release. Am J Psychiatry. 2004; 161(7): 1211-8.
Thompson, P. M.; Hayashi, K. M.; Simon, S. L.; Geaga, J. A.; Hong, M. S.; Sui, Y.; Lee, J. Y.; Toga, A. W.; Ling, W.; London, E. D. Structural abnormalities in the brains of human subjects who use methamphetamine. J Neurosci. 2004; 24(26): 6028-36.
Kimes, A. S.; Horti, A. G.; London, E. D.; Chefer, S. I.; Contoreggi, C.; Ernst, M.; Friello, P.; Koren, A. O.; Kurian, V.; Matochik, J. A.; Pavlova, O.; Vaupel, D. B.; Mukhin, A. G. 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans. FASEB J. 2003; 17(10): 1331-3.
Ernst, M.; Grant, S. J.; London, E. D.; Contoreggi, C. S.; Kimes, A. S.; Spurgeon, L. Decision making in adolescents with behavior disorders and adults with substance abuse. Am J Psychiatry. 2003; 160(1): 33-40.
Ernst, M.; Kimes, A. S.; London, E. D.; Matochik, J. A.; Eldreth, D.; Tata, S.; Contoreggi, C.; Leff, M.; Bolla, K. Neural substrates of decision making in adults with attention deficit hyperactivity disorder. Am J Psychiatry. 2003; 160(6): 1061-70.
Leff, M. K.; Moolchan, E. T.; Cookus, B. A.; Spurgeon, L.; Evans, L. A.; London, E. D.; Kimes, A.; Schroeder, J. R.; Ernst, M. Predictors of smoking initiation among at risk youth: A controlled study. Journal of Child & Adolescent Substance Abuse 2003; 13(1): 59-75.
Ernst, M.; Bolla, K.; Mouratidis, M.; Contoreggi, C.; Matochik, J. A.; Kurian, V.; Cadet, J. L.; Kimes, A. S.; London, E. D. Decision-making in a risk-taking task: a PET study. Neuropsychopharmacology. 2002; 26(5): 682-91.
Bonson, K. R.; Grant, S. J.; Contoreggi, C. S.; Links, J. M.; Metcalfe, J.; Weyl, H. L.; Kurian, V.; Ernst, M.; London, E. D. Neural systems and cue-induced cocaine craving. Neuropsychopharmacology. 2002; 26(3): 376-86.
Fujita, M.; Seibyl, J. P.; Vaupel, D. B.; Tamagnan, G.; Early, M.; Zoghbi, S. S.; Baldwin, R. M.; Horti, A. G.; Kore, N. Ao; Mukhin, A. G.; Khan, S.; Bozkurt, A.; Kimes, A. S.; London, E. D.; Innis, R. B. Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjects. Eur J Nucl Med Mol Imaging. 2002; 29(2): 183-90.
Ernst, M.; Matochik, J. A.; Heishman, S. J.; Van Horn, J. D.; Jons, P. H.; Henningfield, J. E.; London, E. D. Effect of nicotine on brain activation during performance of a working memory task. Proc Natl Acad Sci U S A. 2001; 98(8): 4728-33.
Ernst, M.; Heishman, S. J.; Spurgeon, L.; London, E. D. Smoking history and nicotine effects on cognitive performance. Neuropsychopharmacology. 2001; 25(3): 313-9.
Mukhin, A. G.; Gundisch, D.; Horti, A. G.; Koren, A. O.; Tamagnan, G.; Kimes, A. S.; Chambers, J.; Vaupel, D. B.; King, S. L.; Picciotto, M. R.; Innis, R. B.; London, E. D. 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol. 2000; 57(3): 642-9.
Horti, A. G.; Chefer, S. I.; Mukhin, A. G.; Koren, A. O.; Gundisch, D.; Links, J. M.; Kurian, V.; Dannals, R. F.; London, E. D. 6-[18F]fluoro-A-85380, a novel radioligand for in vivo imaging of central nicotinic acetylcholine receptors. Life Sci. 2000; 67(4): 463-9.
Bartzokis, G.; Lu, P. H.; Beckson, M.; Rapoport, R.; Grant, S.; Wiseman, E. J.; London, E. D. Abstinence from cocaine reduces high-risk responses on a gambling task. Neuropsychopharmacology. 2000; 22(1): 102-3.
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