FACULTY RESEARCH

Faculty List

Anna M Wu, Ph.D.

Work Email Address: awu@mednet.ucla.edu

Work Phone Number: (310) 794-5088

Laboratory Address:
Crump Institute
Los Angeles, CA 90095

Office Address:
CNSI 4335, Crump Institute,570 Westwood Plaza
Los Angeles, CA 90095

Department / Division Affiliations
Director, JCCC Cancer Molecular Imaging
Professor, Biomedical Physics IDP, Molecular & Medical Pharmacology
Member, ACCESS Program: Dept. of Molecular & Medical Pharmacology, DOE Funded Faculty, Access Molecular Pharmacology: Therapeutics, Diagnostics, and Biology of Disease Home Area, Access Physics & Biology in Medicine Home Area, California NanoSystems Institute, JCCC Genitourinary Oncology Program Area, Pharmacology Home Area
Faculty, Cellular and Molecular Pathology PhD Program, Crump Institute for Molecular Imaging


Publications
Shimazaki, K., Lepin, E.J., Wei, B., Nagy, A., Coulum, P., Mareninov, S., Fu, M., Wu, A.M., Marks, J.D., Braun, J., Gordon, L.K., and Wadehra, M. Diabodies targeting epithelial membrane protein 2 reduce tumorigenicity of human endometrial cancer cell lines. Clin. Cancer Res. 2008; 14: 7367-7377.
Kenanova, V.E., Barat, B., Olafsen, T., Chatziioannou, A., Herschman, H.R., Braun, J., and Wu, A.M. Recombinant carcinoembryonic antigen as a reporter gene for molecular imaging. Eur. J. Nucl. Med. Molec. Imaging. 2008; 36: 104-114.
Sirk, S., Olafsen, T., Barat, B., Bauer, K. B., McCabe, K.E., and Wu, A.M. Site-specific thiol-mediated conjugation of fluorescent probes to cysteine-modified diabodies targeting CD20 or HER2. Bioconjugate Chemistry. 2008; 19: 2527-2534.
Schipper, M.L., Cheng, Z., Lee, S.-W., Bentolila, L.A., Iyer, G., Rao, J., Chen, X., Wu, A.M., Weiss, S., and Gambhir, S.S. MicroPET-based biodistribution of quantum dots in living mice. J. Nucl. Med. 2007; 48: 1511-1518.
Olafsen Tove, Sirk Shannon J, Betting David J, Kenanova Vania E, Bauer Karl B, Ladno Waldemar, Raubitschek Andrew A, Timmerman John M, Wu Anna M ImmunoPET imaging of B-cell lymphoma using 124I-anti-CD20 scFv dimers (diabodies). Protein engineering, design & selection : PEDS. 2010; 23(4): 243-9.
Gagnon Pete, Cheung Chia-Wei, Lepin Eric J, Wu Anna M, Sherman Mark A, Raubitschek Andrew A, Yazaki Paul J Minibodies and Multimodal Chromatography Methods: A Convergence of Challenge and Opportunity. BioProcess international. 2010; 8(2): 26-35.
Olafsen Tove, Young Stephen G, Davies Brandon S J, Beigneux Anne P, Kenanova Vania E, Voss Constance, Young Glen, Wong Koon-Pong, Barnes Richard H, Tu Yiping, Weinstein Michael M, Nobumori Chika, Huang Sung-Cheng, Goldberg Ira J, Bensadoun André, Wu Anna M, Fong Loren G Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning. The Journal of biological chemistry. 2010; 285(50): 39239-48.
Olafsen Tove, Sirk Shannon J, Olma Sebastian, Shen Clifton K-F, Wu Anna M ImmunoPET using engineered antibody fragments: fluorine-18 labeled diabodies for same-day imaging. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2012; 132(2): .
McCabe Katelyn E, Liu Bin, Marks James D, Tomlinson James S, Wu Hong, Wu Anna M An Engineered Cysteine-Modified Diabody for Imaging Activated Leukocyte Cell Adhesion Molecule (ALCAM)-Positive Tumors. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2011; 10(3): .
Barat Bhaswati, Kenanova Vania E, Olafsen Tove, Wu Anna M Evaluation of two internalizing carcinoembryonic antigen reporter genes for molecular imaging. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2011; 13(3): 526-35.
Kenanova Vania E, Olafsen Tove, Salazar Felix B, Williams Lawrence E, Knowles Scott, Wu Anna M Tuning the serum persistence of human serum albumin domain III:diabody fusion proteins. Protein engineering, design & selection : PEDS. 2010; 23(10): 789-98.
Frank Richard T, Edmiston Marissa, Kendall Stephen E, Najbauer Joseph, Cheung Chia-Wei, Kassa Thewodros, Metz Marianne Z, Kim Seung U, Glackin Carlotta A, Wu Anna M, Yazaki Paul J, Aboody Karen S Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies. PloS one. 2009; 4(12): e8314.
Wong Jeffrey Y C, Raubitschek Andrew, Yamauchi Dave, Williams Lawrence E, Wu Anna M, Yazaki Paul, Shively John E, Colcher David, Somlo George A pretherapy biodistribution and dosimetry study of indium-111-radiolabeled trastuzumab in patients with human epidermal growth factor receptor 2-overexpressing breast cancer. Cancer biotherapy & radiopharmaceuticals. 2010; 25(4): 387-94.
Afshar Sepideh, Olafsen Tove, Wu Anna M, Morrison Sherie L Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT. Journal of experimental & clinical cancer research : CR. 2009; 28(12): 147.
Lepin Eric J, Leyton Jeffrey V, Zhou Yu, Olafsen Tove, Salazar Felix B, McCabe Katelyn E, Hahm Scott, Marks James D, Reiter Robert E, Wu Anna M An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors. European journal of nuclear medicine and molecular imaging. 2010; 37(8): 1529-38.
Morizono Kouki, Xie Yiming, Olafsen Tove, Lee Benhur, Dasgupta Asim, Wu Anna M, Chen Irvin S Y The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry. Cell host & microbe. 2011; 9(4): 286-98.
Sherman David J, Kenanova Vania E, Lepin Eric J, McCabe Katelyn E, Kamei Ken-Ichiro, Ohashi Minori, Wang Shutao, Tseng Hsian-Rong, Wu Anna M, Behrenbruch Christian P A differential cell capture assay for evaluating antibody interactions with cell surface targets. Analytical biochemistry. 2010; 401(2): 173-81.
Olafsen Tove, Betting David, Kenanova Vania E, Salazar Felix B, Clarke Pat, Said Jonathan, Raubitschek Andrew A, Timmerman John M, Wu Anna M Recombinant anti-CD20 antibody fragments for small-animal PET imaging of B-cell lymphomas. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2009; 50(9): 1500-8.
McCabe Katelyn E, Wu Anna M Positive progress in immunoPET--not just a coincidence. Cancer biotherapy & radiopharmaceuticals. 2010; 25(3): 253-61.
Barat Bhaswati, Sirk Shannon J, McCabe Katelyn E, Li Jianqing, Lepin Eric J, Remenyi Roland, Koh Ai Leen, Olafsen Tove, Gambhir Sanjiv S, Weiss Shimon, Wu Anna M Cys-diabody quantum dot conjugates (immunoQdots) for cancer marker detection. Bioconjugate chemistry. 2009; 20(8): 1474-81.
Vaidyanathan Ganesan, Jestin Emmanuelle, Olafsen Tove, Wu Anna M, Zalutsky Michael R Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK. Nuclear medicine and biology. 2009; 36(6): 671-80.
Olafsen Tove, Wu Anna M Antibody vectors for imaging. Seminars in nuclear medicine. 2010; 40(3): 167-81.
Liu Kan, Lepin Eric J, Wang Ming-Wei, Guo Feng, Lin Wei-Yu, Chen Yi-Chun, Sirk Shannon J, Olma Sebastian, Phelps Michael E, Zhao Xing-Zhong, Tseng Hsian-Rong, Michael van Dam R, Wu Anna M, Shen Clifton K-F Microfluidic-based 18F-labeling of biomolecules for immuno-positron emission tomography. Molecular imaging. 2011; 10(3): 168-76, 1-7.
Liu Kan, Wang Ming-Wei, Lin Wei-Yu, Phung Duy Linh, Girgis Mark D, Wu Anna M, Tomlinson James S, Shen Clifton K-F Molecular Imaging Probe Development using Microfluidics. Current organic synthesis. 2011; 8(4): 473-487.
Fu Maoyong, Brewer Sarah, Olafsen Tove, Wu Anna M, Gordon Lynn K, Said Jonathan, Braun Jonathan, Wadehra Madhuri Positron Emission Tomography Imaging of Endometrial Cancer Using Engineered Anti-EMP2 Antibody Fragments. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2012; 36(3): .
Knowles Scott M, Wu Anna M Advances in immuno-positron emission tomography: antibodies for molecular imaging in oncology. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2012; 30(31): 3884-92.
Girgis Mark D, Kenanova Vania, Olafsen Tove, McCabe Katelyn E, Wu Anna M, Tomlinson James S Anti-CA19-9 diabody as a PET imaging probe for pancreas cancer. The Journal of surgical research. 2011; 170(2): 169-78.
Andersen Jan Terje, Foss Stian, Kenanova Vania E, Olafsen Tove, Leikfoss Ingvild S, Roopenian Derry C, Wu Anna M, Sandlie Inger Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life. The Journal of biological chemistry. 2012; 287(27): 22927-37.
Federman Noah, Chan Jason, Nagy Jon O, Landaw Elliot M, McCabe Katelyn, Wu Anna M, Triche Timothy, Kang Hyunggyoo, Liu Bin, Marks James D, Denny Christopher T Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor. Sarcoma. 2012; 2012(2): 126906.