FACULTY RESEARCH

Faculty List

Jorge R. Barrio, Ph.D.

Work Email Address: jbarrio@mednet.ucla.edu

Office Phone Number: 310-825-4167

Mailing Address:
David Geffen School of Medicine at UCLA
Department of Molecular and Medical Pharmacology
B2-086 CHS
Los Angeles, CA

Office Address:
CHS B2-086A
694817

Department / Division Affiliations
Distinguished Professor, Molecular & Medical Pharmacology
Professor, Biomedical Physics IDP
Member, DOE Funded Faculty, ACCESS Program, Access Biomedical Physics Home Area, Access Molecular Pharmacology: Therapeutics, Diagnostics, and Biology of Disease Home Area, Brain Research Institute, JCCC Cancer Molecular Imaging, Pharmacology Home Area

Research Interests
Our Laboratory has more than 40 years of experience developing molecular imaging probes and investigating the intricate mechanisms of human disease. Synthetic chemistry, radiochemistry, biochemistry and molecular imaging methods in both animal models and humans cover the scope of our research. We have earlier discovered unique nucleoside and nucleotide fluorescent probes which are still widely used for probing DNA and RNA structures. At UCLA in the late 70s, in the early times of the development of positron emission tomography (PET), we expanded our research to include positron emitting labeled isotopes to measure specific enzymatic and neurotransmitter processes functionally deficient in movement disorders. Our earlier work has led to the discovery of essential mechanisms of neurotransmitter synthesis associated with neuronal transport and the validation of 6-[F-18]fluoro-L-DOPA as a PET diagnostic probe for Parkinsons disease. The goal of our current research is two-fold: (1) to design, synthesize, test and validate new molecular imaging probes for tau amyloid, prion and other brain pathologies in neurodegenerative diseases. Our Laboratory first demonstrated the feasibility of in vivo visualization of amyloid and tau aggregates in the living brain of Alzheimers disease patients using [F-18]FDDNP. Currently the overall goal is to discover molecular structures with differential in vivo sensitivity and specificity for tau and amyloid aggregates present in the various neurodegenerative diseases; and (2) to design, synthesize, test and validate new specific molecular imaging probes for SGLTs (i.e., SGLT1 and SGLT2) to measure the in vivo glucose utilization via these transporters. Working with Dr Wrights team, our Laboratories first demonstrated the ex vivo and in vivo mapping and functionality of SGLT transporters in rodents and humans using 4-[F-18]FDG and other specific substrate and inhibitor probes. Currently we are investigating these probes to visualize the expression and functional activity of SGLTs in various human diseases, including cancer.. Recipient of US Department of Energy and NIH funded grants our Laboratory has successfully administered projects and established collaborations with investigators at UCLA and elsewhere in the world, which is strongly supported by our publication record in leading peer review journals. Our objective is also to continue strengthening these research collaborations.


Publications
Hummel Charles S, Lu Chuan, Liu Jie, Ghezzi Chiari, Hirayama Bruce A, Loo Donald D F, Kepe Vladimir, Barrio Jorge R, Wright Ernest M Structural selectivity of human SGLT inhibitors. American journal of physiology. Cell physiology. 2012; 302(2): C373-82.
Landau Meytal, Sawaya Michael R, Faull Kym F, Laganowsky Arthur, Jiang Lin, Sievers Stuart A, Liu Jie, Barrio Jorge R, Eisenberg David Towards a pharmacophore for amyloid. PLoS biology. 2011; 9(6): e1001080.
Teng Edmond, Kepe Vladimir, Frautschy Sally A, Liu Jie, Satyamurthy Nagichettiar, Yang Fusheng, Chen Ping-Ping, Cole Graham B, Jones Mychica R, Huang Sung-Cheng, Flood Dorothy G, Trusko Stephen P, Small Gary W, Cole Gregory M, Barrio Jorge R [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment. Neurobiology of disease. 2011; 43(3): 565-75.
Protas, HD et al. FDDNP Binding Using MR Derived Cortical Surface Maps. Neuroimage 2010; 49: 240-248.
Yu Amy S, Hirayama Bruce A, Timbol Gerald, Liu Jie, Basarah Ernest, Kepe Vladimir, Satyamurthy Nagichettiar, Huang Sung-Cheng, Wright Ernest M, Barrio Jorge R Functional expression of SGLTs in rat brain. American journal of physiology. Cell physiology. 2010; 299(6): C1277-84.
Cole Graham B, Keum Gyochang, Liu Jie, Small Gary W, Satyamurthy Nagichettiar, Kepe Vladimir, Barrio Jorge R Specific estrogen sulfotransferase (SULT1E1) substrates and molecular imaging probe candidates. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(14): 6222-7.
Barrio Jorge R, Satyamurthy Nagichettiar, Huang Sung-Cheng, Petric Andrej, Small Gary W, Kepe Vladimir Dissecting molecular mechanisms in the living brain of dementia patients. Accounts of chemical research. 2009; 42(7): 842-50.
Small Gary W, Bookheimer Susan Y, Thompson Paul M, Cole Greg M, Huang S-C, Kepe Vladimir, Barrio Jorge R Current and future uses of neuroimaging for cognitively impaired patients. Lancet neurology. 2008; 7(2): 161-72.
Liu Jie, Kepe Vladimir, Zabjek Alenka, Petric Andrej, Padgett Henry C, Satyamurthy Nagichettiar, Barrio Jorge R High-yield, automated radiosynthesis of 2-(1-{6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile ([18F]FDDNP) ready for animal or human administration. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2008; 9(1): 6-16.
Radu Caius G, Shu Chengyi J, Nair-Gill Evan, Shelly Stephanie M, Barrio Jorge R, Satyamurthy Nagichettiar, Phelps Michael E, Witte Owen N Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2'-deoxycytidine analog. Nature medicine. 2008; 14(7): 783-8.
Small Gary W, Kepe Vladimir, Ercoli Linda M, Siddarth Prabha, Bookheimer Susan Y, Miller Karen J, Lavretsky Helen, Burggren Alison C, Cole Greg M, Vinters Harry V, Thompson Paul M, Huang S-C, Satyamurthy N, Phelps Michael E, Barrio Jorge R PET of brain amyloid and tau in mild cognitive impairment. The New England journal of medicine. 2006; 355(25): 2652-63.
Kepe Vladimir, Barrio Jorge R, Huang Sung-Cheng, Ercoli Linda, Siddarth Prabha, Shoghi-Jadid Kooresh, Cole Gregory M, Satyamurthy Nagichettiar, Cummings Jeffrey L, Small Gary W, Phelps Michael E Serotonin 1A receptors in the living brain of Alzheimer's disease patients. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103(3): 702-7.
Peñuelas Iván, Mazzolini Guillermo, Boán José F, Sangro Bruno, Martí-Climent Josep, Ruiz María, Ruiz Juan, Satyamurthy Nagichettiar, Qian Cheng, Barrio Jorge R, Phelps Michael E, Richter José A, Gambhir Sanjiv S, Prieto Jesús Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients. Gastroenterology. 2005; 128(7): 1787-95.
Shoghi-Jadid, K Small, GW Agdeppa, ED Kepe, V Ercoli, LM Siddarth, P Read, S Satyamurthy, N Petric, A Huang, SC Barrio, JR Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. . 2002; 10(1): 24-35.
Sun, X Annala, AJ Yaghoubi, SS Barrio, JR Nguyen, KN Toyokuni, T Satyamurthy, N Namavari, M Phelps, ME Herschman, HR Gambhir, SS Quantitative imaging of gene induction in living animals. Gene therapy. . 2001; 8(20): 1572-9.