UCLA Molecular and Medical Pharmacology  









Faculty

Department / Division Affiliations
Associate Professor, Molecular & Medical Pharmacology
Faculty, Crump Institute for Molecular Imaging
Member, Cancer Molecular Imaging, JCCC Cancer Cell Biology Program Area
ACCESS Affinity Group:
ACCESS Affinity - Molecular & Medical Pharmacology
Research Interest:
Interfacing Biology and Physical Sciences by Microfluidic and Nanoelectronic Circuits: Our research interests are to develop microfluidics-based technology platforms and to utilize these technology platforms to address important issues in the fields of molecular imaging, cancer biology and chemistry. In contrast to conventional bench-top setups, microfluidics has been used to manipulate chemical and biological processes on nanoliter (nL) to microliter (mL) scales with the profound advantages of enhanced heat transfer performance, faster diffusion time and reaction kinetics, as well as improved control over experimental conditions. By incorporating integrated microvalves into microfluidic batch systems, the integrated microfluidic platforms enable the execution and automation of multiple, parallel, and/or sequential chemical or biological processes on a single chip under digital control. For the past two years, we have been working with several research groups who have expertise covering molecular imaging, cancer biology, immunology and pathology to develop a variety of functioning microfluidic platforms for applications in three major areas of interest:

(i) Development of Molecular Imaging Probes

(ii) Biological Analysis

(iii) Production of Nanostructured Materials

In a boarder playing field, our goal remains the creation of further integrated microfluidic technology platforms for the broader space in chemistry and biology beyond a single functioning platform on a chip. We will compile many different microfluidic platforms to produce a number of game systems: "Let's Play _____", where the blank is "systems biology of disease", "biomarkers", "pharmacology", "biochemical reaction kinetics", "chemistry" and "cancer diagnosis" etc. where execution is rapid and learning curves are steep.

For more detailed information, please visit the lab website.
Bio:
Dr. Tseng���s research interests include the development of microfluidics-based technology platforms and their use to address important issues in the fields of molecular imaging, cancer biology and chemistry. He has been an Assistant Professor in the Department of Molecular & Medical Pharmacology in David Geffen School of Medicine at the University of California, Los Angeles (UCLA) since 2003. Prior to that, he was a postdoctoral researcher with Drs. Fraser Stoddart and Jim Heath at the Department of Chemistry and Biochemistry of the UCLA (2000-2003). To date, He has published more than 53 peer-reviewed papers, 3 book chapters and 14 conference proceedings, covering the fields of organic chemistry, supramolecular chemistry, molecular electronics and microfluidics.
 

Hsian-Rong Tseng, Ph.D.

Email Address:
hrtseng@mednet.ucla.edu

Address:
Office
CNSI, 570 Westwood Plaza
Los Angeles, CA 90095
UNITED STATES

Phone Number:
310-206-8975
Phone Number:
1-310-206 7320
1-310-794 1977


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Publications:
Wang, H. Wang, S. Su, H. Chen, K. J. Armijo, A. L. Lin, W. Y. Wang, Y. Sun, J. Kamei, K. I. Czernin, J. Radu, C. G. Tseng, H. R. A Supramolecular Approach for Preparation of Size-Controlled Nanoparticles. Angew Chem Int Ed Engl. 2009; 48(24): 4344-4348.
Kamei, K. Guo, S. Yu, Z. T. Takahashi, H. Gschweng, E. Suh, C. Wang, X. Tang, J. McLaughlin, J. Witte, O. N. Lee, K. B. Tseng, H. R. An integrated microfluidic culture device for quantitative analysis of human embryonic stem cells. Lab Chip. 2009; 9(4): 555-63.
Coti, K. K. Wang, Y. Lin, W. Y. Chen, C. C. Tak For Yu, Z. Liu, K. Shen, C. K. Selke, M. Yeh, A. Lu, W. Tseng, H. R. A dynamic micromixer for arbitrary control of disguised chemical selectivity. Chem Commun (Camb). 2008; (29): 3426-8.
Sui, G. Lee, C. C. Kamei, K. Li, H. J. Wang, J. Y. Wang, J. Herschman, H. R. Tseng, H. R. A microfluidic platform for sequential ligand labeling and cell binding analysis. Biomed Microdevices. 2007; 9(3): 301-5.
Green JE, Choi JW, Boukai A, Bunimovich Y, Johnston-Halperin E, DeIonno E, Luo Y, Sheriff BA, Xu K, Shin YS, Tseng HR, Stoddart JF, Heath JR A 160-Kilobit Molecular Electronic Memory Patterned at 1011 Bits per Square Centimeter. Nature 2007; 445: 414-417.
Sui G, Tseng HR Reactions in Hand. Nano Today 2006; 1: 6-7.
Clark, A. P. Cadby, A. J. Shen, C. K. Rubin, Y. Tolbert, S. H. Synthesis and self-assembly of an amphiphilic poly(phenylene ethynylene) ionomer. J Phys Chem B. 2006; 110(44): 22088-96.
Sui G, Wang J, Lee CC, Lee SP, Leyton JV, Wu AM, Tseng HR Solution-Phase Surface Modification in Intact Poly(dimethylsiloxane) Microfluidic Channels. Anal. Chem. 2006; 78: 5543-5551.
Lee CC, Sui G, Elizarov A, Shu CJ, Shin YS, Doole AN, Stout D, Witte ON, Kolb HC, Satyamurthy N, Heath JR, Phelps ME, Quake SR, Tseng HR MultiStep Synthesis of a Radiolabeled Imaging Probe using Integrated Microfluidics. Science 2005; 310: 1793-1796.
Alam, M. M. Wang, J. Guo, Y. Lee, S. P. Tseng, H. R. Electrolyte-gated transistors based on conducting polymer nanowire junction arrays. J Phys Chem B. 2005; 109(26): 12777-84.
Nguyen TD, Tseng HR, Celestre PC, Flood AH, Liu Y, Stoddart JF, Zink JI A reversible molecular valve.. Proceedings of the National Academy of Sciences of the United States of America. . 2005; 102(29): 10029-34.
Liu Y, Flood AH, Bonvallet PA, Vignon SA, Northrop BH, Tseng HR, Jeppesen JO, Huang TJ, Brough B, Baller M, Magonov S, Solares SD, Goddard WA, Ho CM, Stoddart JF Linear artificial molecular muscles.. Journal of the American Chemical Society. . 2005; 127(27): 9745-59.
Wang J, Chan S, Carlson SS, Luo Y, Ge G, Ries RS, Heath JR, Tseng HR "Electrochemically Fabricated Polyaniline Nanoframework Electrode Junctions That Function as Resistive Sensors". Nano Lett. 2004; 4: 1693-1697.
Huang TJ, Brough B, Ho CM, Liu Y, Flood AH, Bonvallet PA, Tseng HR, Stoddart JF, Baller M, Magonov M "A Nanomechanical Device Based on Linear Molecular Motors". Appl. Phys. Lett. 2004; 85: 5391-5393.
Hernandez R, Tseng HR, Wong JW, Stoddart JF, Zink JI An operational supramolecular nanovalve.. Journal of the American Chemical Society. . 2004; 126(11): 3370-1.
Marchioni F, Venturi M, Ceroni P, Balzani V, Belohradsky M, Elizarov AM, Tseng HR, Stoddart JF Complete charge pooling is prevented in viologen-based dendrimers by self-protection.. Chemistry (Weinheim an der Bergstrasse, Germany) . 2004; 10(24): 6361-8.
Tseng HR, Wu D, Fang NX, Zhang X, Stoddart JF The Metastability of an Electrochemical Controlled Nanoscale Machine on Gold Surfaces. ChemPhysChem 2004; (5): 111-116.
Diehl MR, Steuerman DW, Tseng HR, Vignon SA, Star A, Celestre PC, Stoddart JF, Heath JR Single-walled carbon nanotube based molecular switch tunnel junctions.. Chemphyschem : a European journal of chemical physics and physical chemistry. . 2003; 4(12): 1335-9.
Yu H, Luo Y, Beverley K, Tseng HR, Stoddart JF, Heath JR The Molecule / Electrode Interfaces in Single-Molecule Transistors. Angew. Chem. Int. Ed. 2003; (42): 5706-5711.
Tseng HR, Vignon SA, Stoddart JF Toward chemically controlled nanoscale molecular machinery.. Angewandte Chemie (International ed. in English) . 2003; 42(13): 1491-5.