FACULTY RESEARCH

Faculty List

Srinivasa T. Reddy, Ph.D.

Work Email Address: sreddy@mednet.ucla.edu

Lab Number: 310-206-3605
310-794-5819
310-794-7107

Office Phone Number: 310-206-3915

Laboratory Address:
3535, MRL
Los Angeles, CA 90095 CHS/BRI A8-122
650 Charles Young Drive South

Office Address:
3736 MRL

Department / Division Affiliations
Professor in Residence, Department of Medicine, Molecular & Medical Pharmacology
Member, JCCC Tumor Immunology Program Area, Molecular Pharmacology GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area
Faculty, Cardiology

Research Interests
Inflammatory signals, including exogenous mediators such as lipopolysaccharide and endogenous mediators such as cytokines, stimulate cellular phospholipase (PLA2) activities resulting in the release of arachidonic acid from membrane phospholipid stores. Arachidonic acid is converted into prostaglandins, prostacyclins and thromboxanes by the cyclooxygenase (COX) pathway or leukotrienes and hydroxyeicosatetraenoic acids (HETEs) by the lipoxygenase (LO) pathway. Prostaglandins and other derivatives of arachidonic acid metabolism, are involved in a number of physiological and pathophysiological phenomenon including: acute and chronic inflammation, cardiovascular disease, immune response, arthritis, inflammatory bowel disease, respiratory disorders and colon cancer. My laboratory is interested in understanding the expression and regulation of enzymes involved in arachidonic acid metabolism, especially, cyclooxygenases, lipoxygenases and phospholipases and their role in the development of cardiovascular diseases such as atherosclerosis. Currently, my laboratory is looking at the role of cyclooxygenases in atherosclerotic lesion formation using animal models. Atherosclerosis Research Unit (ARU) at UCLA identified a series of biologically active oxidized lipids, derived from an arachidonic acid containing phospholipid; palmitoyl arachidonyl phosphatidyl choline (PAPC). These oxidized lipids are potent mediators of monocyte adhesion and migration, which is an early event in the development of atherosclerotic lesions. In collaboration with ARU faculty, we completed a screen to identify genes, whose expression is regulated by the biologically active oxidized lipids in human aortic endothelial cells. We have cloned a number of interesting genes and are currently in the process of characterizing some of thege genes and determining their role in the development of atherosclerotic lesions in animal models. <p> For more detailed information, please visit the <a href="http://149.142.143.90:8099/fac_research/pharmlabs?lab=reddy" Target="new">lab website</a>.


Publications
Ganapathy Ekambaram, Su Feng, Meriwether David, Devarajan Asokan, Grijalva Victor, Gao Feng, Chattopadhyay Arnab, Anantharamaiah G M, Navab Mohamad, Fogelman Alan M, Reddy Srinivasa T, Farias-Eisner Robin D-4F, an apoA-I mimetic peptide, inhibits proliferation and tumorigenicity of epithelial ovarian cancer cells by upregulating the antioxidant enzyme MnSOD. International journal of cancer. Journal international du cancer. 2012; 130(5): 1071-81.
Navab Mohamad, Reddy Srinivasa T, Anantharamaiah G M, Hough Greg, Buga Georgette M, Danciger Jan, Fogelman Alan M D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice. Journal of lipid research. 2012; 53(3): 437-45.
Su Feng, Grijalva Victor, Navab Kaveh, Ganapathy Ekambaram, Meriwether David, Imaizumi Satoshi, Navab Mohamad, Fogelman Alan M, Reddy Srinivasa T, Farias-Eisner Robin HDL mimetics inhibit tumor development in both induced and spontaneous mouse models of colon cancer. Molecular cancer therapeutics. 2012; .
Hong Cynthia, Bradley Michelle N, Rong Xin, Wang Xuping, Wagner Alan, Grijalva Victor, Castellani Lawrence W, Salazar Jon, Realegeno Susan, Boyadjian Rima, Fogelman Alan M, Van Lenten Brian J, Reddy Srinivasa T, Lusis Aldons J, Tangirala Rajendra K, Tontonoz Peter LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice. Journal of lipid research. 2012; .
Charles-Schoeman Christina, Lee Yuen Yin, Grijalva Victor, Amjadi Sogol, Fitzgerald John, Ranganath Veena K, Taylor Mihaela, McMahon Maureen, Paulus Harold E, Reddy Srinivasa T Cholesterol efflux by high density lipoproteins is impaired in patients with active rheumatoid arthritis. Annals of the rheumatic diseases. 2012; .
Watanabe Junji, Charles-Schoeman Christina, Miao Yunan, Elashoff David, Lee Yuen Yin, Katselis George, Lee Terry D, Reddy Srinivasa T Proteomic profiling following immunoaffinity capture of HDL: Association of acute phase proteins and complement factors with pro-inflammatory HDL in rheumatoid arthritis. Arthritis and rheumatism. 2012; .
Kelesidis Theodoros, Currier Judith S, Huynh Diana, Meriwether David, Charles-Schoeman Christina, Reddy Srinivasa T, Fogelman Alan M, Navab Mohamad, Yang Otto O A biochemical fluorometric method for assessing the oxidative properties of HDL. Journal of lipid research. 2011; 52(12): 2341-51.
Kim Juyong Brian, Xia Yu-Rong, Romanoski Casey E, Lee Sangderk, Meng YongHong, Shi Yi-Shou, Bourquard Noam, Gong Ke Wei, Port Zachary, Grijalva Victor, Reddy Srinivasa T, Berliner Judith A, Lusis Aldons J, Shih Diana M Paraoxonase-2 modulates stress response of endothelial cells to oxidized phospholipids and a bacterial quorum-sensing molecule. Arteriosclerosis, thrombosis, and vascular biology. 2011; 31(11): 2624-33.
Janzen Carla, Sen Suvajit, Cuevas Janis, Reddy Srinivasa T, Chaudhuri Gautam Protein phosphatase 2A promotes endothelial survival via stabilization of translational inhibitor 4E-BP1 following exposure to tumor necrosis factor-α. Arteriosclerosis, thrombosis, and vascular biology. 2011; 31(11): 2586-94.
Morgantini Cecilia, Natali Andrea, Boldrini Beatrice, Imaizumi Satoshi, Navab Mohamad, Fogelman Alan M, Ferrannini Ele, Reddy Srinivasa T Anti-inflammatory and antioxidant properties of HDLs are impaired in type 2 diabetes. Diabetes. 2011; 60(10): 2617-23.
Meriwether David, Imaizumi Satoshi, Grijalva Victor, Hough Greg, Vakili Ladan, Anantharamaiah G M, Farias-Eisner Robin, Navab Mohamad, Fogelman Alan M, Reddy Srinivasa T, Shechter Ishaiahu Enhancement by LDL of transfer of L-4F and oxidized lipids to HDL in C57BL/6J mice and human plasma. Journal of lipid research. 2011; 52(10): 1795-809.
Navab Mohamad, Reddy Srinivasa T, Anantharamaiah G M, Imaizumi Satoshi, Hough Greg, Hama Susan, Fogelman Alan M Intestine may be a major site of action for the apoA-I mimetic peptide 4F whether administered subcutaneously or orally. Journal of lipid research. 2011; 52(6): 1200-10.
Bourquard Noam, Ng Carey J, Reddy Srinivasa T Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response. The Biochemical journal. 2011; 436(1): 91-100.
Vasquez Sergio X, Gao Feng, Su Feng, Grijalva Victor, Pope John, Martin Bill, Stinstra Jeroen, Masner Matthew, Shah Neha, Weinstein David M, Farias-Eisner Robin, Reddy Srinivasa T Optimization of microCT imaging and blood vessel diameter quantitation of preclinical specimen vasculature with radiopaque polymer injection medium. PloS one. 2011; 6(4): e19099.
Navab Mohamad, Reddy Srinivasa T, Van Lenten Brian J, Fogelman Alan M HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms. Nature reviews. Cardiology. 2011; 8(4): 222-32.
Gao Feng, Vasquez Sergio X, Su Feng, Roberts Svetlana, Shah Neha, Grijalva Victor, Imaizumi Satoshi, Chattopadhyay Arnab, Ganapathy Ekambaram, Meriwether David, Johnston Brad, Anantharamaiah G M, Navab Mohamad, Fogelman Alan M, Reddy Srinivasa T, Farias-Eisner Robin L-5F, an apolipoprotein A-I mimetic, inhibits tumor angiogenesis by suppressing VEGF/basic FGF signaling pathways. Integrative biology : quantitative biosciences from nano to macro. 2011; 3(4): 479-89.
Imaizumi Satoshi, Navab Mohamad, Morgantini Cecilia, Charles-Schoeman Christina, Su Feng, Gao Feng, Kwon Murray, Ganapathy Ekambaram, Meriwether David, Farias-Eisner Robin, Fogelman Alan M, Reddy Srinivasa T Dysfunctional high-density lipoprotein and the potential of apolipoprotein A-1 mimetic peptides to normalize the composition and function of lipoproteins. Circulation journal : official journal of the Japanese Circulation Society. 2011; 75(7): 1533-8.
Bui Peter, Imaizumi Satoshi, Beedanagari Sudheer Reddy, Reddy Srinivasa T, Hankinson Oliver Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids. Drug metabolism and disposition: the biological fate of chemicals. 2011; 39(2): 180-90.
Devarajan Asokan, Bourquard Noam, Hama Susan, Navab Mohamad, Grijalva Victor R, Morvardi Susan, Clarke Catherine F, Vergnes Laurent, Reue Karen, Teiber John F, Reddy Srinivasa T Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis. Antioxidants & redox signaling. 2011; 14(3): 341-51.
Watson Catherine E, Weissbach Nicole, Kjems Lise, Ayalasomayajula Surya, Zhang Yiming, Chang Ih, Navab Mohamad, Hama Susan, Hough Greg, Reddy Srinivasa T, Soffer Daniel, Rader Daniel J, Fogelman Alan M, Schecter Alison Treatment of patients with cardiovascular disease with L-4F, an apo-A1 mimetic, did not improve select biomarkers of HDL function. Journal of lipid research. 2011; 52(2): 361-73.