Faculty List

Michael E. Jung, Ph.D.

Email Address: mej@chem.ucla.edu
Work Email Address: jung@chem.ucla.edu

Lab Number: 1 (310) 825-0549

Work Phone Number: 1 (310) 825-7954

Laboratory Address:
Mol Sci Bldg 3210

Work Address:
Mol Sci Bldg 3505A

Department / Division Affiliations
Director, Bioscience Synthetic Chemistry
Professor, Chemistry and Biochemistry, Organic Chemistry
Member, Basic/Translational Research, Jonsson Comprehensive Cancer Center, California NanoSystems Institute
Adjunct Faculty, Molecular & Medical Pharmacology
Researcher, Chemical Biology, Organic, Synthesis

Refik Kayali, Jin-Mo Ku, Gregory Khitrov, Michael E. Jung, Olga Prikhodko, and Carmen Bertoni Read-through compound 13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy. Human Molecular Genetics. 2012; 1-14.
M. C. Wolf, A. N. Freiberg, T.-H. Zhang, Z. Akyol-Ataman, A. Grock, P. W. Hong, J. Li, N. F. Watson, A. Q. Fang, H. C. Aguilar, M. Porotto, A. N. Honko, R. Damoiseaux, J. P. Miller, S. E. Woodson, S. Chantasirivisal, V. Fontanes, O. A. Negrete, P. Krogstad, A. Dasgupta, A. Moscona, L. E. Hensley, S. P. Whenlan, K. F. Faull, M. R. Holbrook, M. E. Jung, and B. Lee A Broad-spectrum Antiviral Targeting Entry of Enveloped Viruses. PNAS. 2010; 107: 3157-62.
Xu W, Cai X, Jung ME, Tang Y Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae. J Am Chem Soc. 2010; 132(39): 13604-7.
Aghajan M, Jonai N, Flick K, Fu F, Luo M, Cai X, Ouni I, Pierce N, Tang X, Lomenick B, Damoiseaux R, Hao R, Del Moral PM, Verma R, Li Y, Li C, Houk KN, Jung ME, Zheng N, Huang L, Deshaies RJ, Kaiser P, Huang J Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nat Biotechnol. 2010; 28(7): 738-42.
Heinz A, Jung MC, Duca L, Sippl W, Taddese S, Ihling C, Rusciani A, Jahreis G, Weiss AS, Neubert RH, Schmelzer CE Degradation of tropoelastin by matrix metalloproteinases--cleavage site specificities and release of matrikines. FEBS J. 2010; 277(8): 1939-56.
M. E. Jung and J. J. Chang Enantiospecific Formal Total Synthesis of (+)-Fawcettimine. Org. Lett. 2010; 12(13): 2962–5.
Jared S. Johnson, Vicente Meliton, Woo Kyun Kim, Kwang-Bok Lee, Jeffrey C. Wang, KhanhLinh Nguyen, Dongwon Yoo, Michael E. Jung, Elisa Atti, Sotirios Tetradis, Renata C. Pereira, Clara Magyar, Taya Nargizyan, Theodore J. Hahn, Francine Farouz, Scott Thies, and Farhad Parhami Novel Osteogenic Oxysterols Induce Osteogenic and Inhibit Adipogenic Differentiation of Marrow Stromal Cells In Vitro and Stimulate Bone Formation and Spinal Fusion In Vivo. Journal of Cellular Biochemistry. 2010; 112(6): 1673-84.
M. E. Jung, S. Ouk, D. Yoo, C. L. Sawyers, C. Chen, C. Tran, and J. Wongvipat Structure-Activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-Resistant Prostate Cancer (CRPC). J. Med. Chem. 2010; 53(7): 2779-96.
Jung ME, Lui RM Studies toward the Total Syntheses of Cucurbitacins B and D. J Org Chem. 2010; 75(21): 7146-58.
Jung ME, Zhang TH, Lui RM, Gutierrez O, Houk KN Synthesis of a trans,syn,trans-dodecahydrophenanthrene via a bicyclic transannular Diels-Alder reaction: intermediate for the synthesis of fusidic acid. J Org Chem. 2010; 75(20): 6933-40.
M. E. Jung, M. Chaumontet, and R. Salehi-Rad Total Synthesis of Auripyrone B Using a Non-Aldol Aldol-Cuprate Opening Process. Org. Lett. 2010; 12(12): 2872-5.
Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen CD, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer . Science . 2009; 324(5928): 787-790.
N. Suree, S. W. Yi, W. Thieu, M. Marohn, R. Damoiseaux, A. Chan, M. E. Jung and R. T. Clubb Discovery and Structure Activity Relationship Analysis of Staphylococcus aureus Sortase A Inhibitors. Bioorg. Med. Chem. 2009; 17(20): 7174-85.
L. Du, R. Damoiseaux, S. Nahas, J. Pollard, J. Goldstine, H. Hu, M. E. Jung, R. A. Gatti Identification of compounds with the ability to induce readthrough of nonsense mutations. J. Experimental Med. 2009; 206(10): 2285-2297.
N. Suree, C. K. Liew, V. Villareal, W. Thieu, E. A. Fadeev, J. J. Clemens, M. E. Jung and R. T. Clubb Structure of the Staphylococcus aureus SrtA sortase covalently bound to a LPXTG sorting signal. J. Biol. Chem. 2009; 284(36): 24465-77.
Jung, M. E. Perez, F. Synthesis of 2-substituted 7-hydroxybenzofuran-4-carboxylates via addition of silyl enol ethers to o-benzoquinone esters. Org Lett. 2009; 11(10): 2165-7.
M. E. Jung and G-Y. Im The Total Synthesis of Racemic Laurenditerpenol, an HIF-1 Inhibitor. J. Org. Chem. 2009; 74(22): 8739–53.
M. E. Jung, J. Cordova, and M. Murakami Total Synthesis of (±)-Kellermanoldione: Stepwise Cycloaddition of a Functionalized Diene and Allenoate. Org. Lett. 2009; 11 (17): 3882-3885.
M. E. Jung and R. Salehi-Rad Total Synthesis of Auripyrone A Using a Tandem Non-Aldol Aldol-Paterson Aldol Process as a Key Step. Angew Chem Int Ed Engl. 2009; 48(46): 8766-9.
Jung, M. E. Allen, D. A. Use of 4-cyanocoumarins as dienophiles in a facile synthesis of highly substituted dibenzopyranones. Org Lett. 2009; 11(3): 757-60.
M. E. Jung and G-Y. Im Convergent Total Synthesis of the Racemic HIF-1 Inhibitor Laurenditerpenol. Tetrahedron Lett. 2008; 49(33): 4962-4964.
M. E. Jung and D. A. Allen Facile Synthesis of syn 2-Alkyl-3-trialkylsilyloxycycloalkanones via the First Non-Aldol Aldol Process of 2,3-Epoxycycloalkanols. Org. Lett. 2008; 10(10): 2039-2041.
W. Zhang, K. Watanabe, X. Cai, M. E. Jung, Y. Tang, and J. Zhan Identifying the Minimal Enzymes Required for Anhydrotetracycline Biosynthesis. J. Am. Chem. Soc. 2008; 130(19): 6068-6069.
M. E. Jung, J. A. Berliner, L. Koroniak, A. D. Watson, and B. G. Gugiu Improved Synthesis of the Epoxy Isoprostane Phospholipid PEIPC and its Reactivity with Amines. Org. Lett. 2008; 10(19): 4207-4209.
M. E. Jung and T.-H. Zhang New Protocol for Anti-Selective Aldol Condensation of Ethyl Ketones with α-Alkoxyaldehydes. Org. Lett. 2008; 10(1): 137-40.
M. E. Jung and H. V. Chu Preparation of a Functionalized Tetracyclic Intermediate for the Synthesis of Rhodexin A. Org. Lett. 2008; 10: 3647-3649.
M. E. Jung and D. Yoo Synthesis of the C1 -C12 Fragment of the Tedanolides. Selective Hydroboration-protonation of Allylic Alcohol Approach. Tetrahedron Lett. 2008; 49(5): 816-819.
M. C. Duncan, D. G. Ho, J. Huang, M. E. Jung, and G. S. Payne Composite Synthetic Lethal Identification of Membrane Traffic Inhibitors. Proc. Natl. Acad. Sci. U. S. A. 2007; 104(15): 6235-6240.
M. C. Duncan, D. G. Ho, J. Huang, M. E. Jung, and G. S. Payne Compound Synthetic Lethal Identification Membrane Traffic Inhibitors. PNAS. 2007; 104(15): 6235-6240.
M. E. Jung and J. M. Murphy Functional Group Selectivity in Reactions of Epoxides with Tungsten Hexachloride. Tetrahedron Lett. 2007; 48(47): 8388-8391.
N. Suree, M. E. Jung, and R. T. Clubb Recent Advances Towards New Anti-infective Agents that Inhibit Cell Surface Protein Anchoring in Staphylococcus aureus and Other Gram-positive Pathogens. Mini Reviews in Medicinal Chemistry. 2007; 7(10): 991-1000.
J. M. Tsay, M. Trzoss, L. Shi, X. Kong, M. Selke, M. E. Jung, and S. Weiss Singlet Oxygen Production by Peptide-Coated Quantum Dot-Photosensitizer Conjugates. J. Am. Chem. Soc. 2007; 129(21): 6865-6871.
M. E. Jung and D. Ho Stepwise Acid-Promoted Double-Michael Process: an Alternative to Diels-Alder Cycloadditions for Hindered Silyloxydiene-Dienophile Pairs. Org. Lett. 2007; 9(2): 375-378.
M. E. Jung and D. Yoo Synthesis of the C1 -C12 Fragment of the Tedanolides. Aldol-Non-Aldol Aldol Approach. Org. Lett 2007; 9: 3543-3546.
M. E. Jung and S.-J. Min Synthetic Approaches to the Synthesis of Arisugacin A. Tetrahedron. 2007; 63(18): 3682-3701.
M. E. Jung and M. Murakami Total Synthesis of (+/-)-Hedychilactone B: Stepwise Allenoate Diene Cycloaddition to Prepare Trimethyldecalin Systems. Org. Lett. 2007; 9(3): 461-463.
M. E. Jung and D. Yoo Unprecedented Rearrangement of a 4-Alkoxy-5-bromoalk-2-en-1-ol to a Cyclopentenone via an Iso-Nazarov Cyclization Process. J. Org. Chem. 2007; 72(22): 8565-8568.
M. T. Naik, N. Suree, N. U. Ilangovan, C. K. Liew, J. Clemens, M. E. Jung, and R. T. Clubb A Calcium Modulated Loop Closure Mechanism Activates Cell Surface Protein Anchoring by the Staphylococcus aureus Sortase A Transpeptidase. J. Biol. Chem. 2006; 281: 1817-1826.
M. E. Jung and W.-J. Kim Practical Syntheses of Dyes for Difference Gel Electrophoresis (DIGE). Bioorg. Med. Chem. 2006; 14(1): 92-97.
M. E. Jung and B. A. Duclos Synthetic Approach to Analogues of Betulinic Acid. Tetrahedron. 2006; 62(40): 9321-9334.
Y.-L. Zhao, C. P. Suhrada, M. E. Jung and K. N. Houk The 3-Vinylmethylenecyclo-butane-4-Methylenecyclohexene Rearrangement: Theoretical Investigation of a Stereo-selective Stepwise Cope Rearrangement. J. Am. Chem. Soc. 2006; 128(34): 11106-11113.
M. E. Jung and M. Murakami Total Synthesis of (+/-)-Hedychenone: Trimethyldecalin Terpenes via Stepwise Allenoate Diene Cycloaddition. Org. Lett. 2006; 8(25): 5857-59.
Jung, M. E. Berliner, J. A. Angst, D. Yue, D. Koroniak, L. Watson, A. D. Li, R. Total synthesis of the epoxy isoprostane phospholipids PEIPC and PECPC. Org Lett. 2005; 7(18): 3933-5.
Jung, M. E. Nishimura, N. Novack, A. R. Versatile diastereoselectivity in formal [3,3]-sigmatropic shifts of substituted 1-alkenyl-3-alkylidenecyclobutanols and their silyl ethers. J Am Chem Soc. 2005; 127(32): 11206-7.
Y. Akiba, M. E. Jung, S. Ouk, and J. D. Kaunitz A Novel Small Molecule CFTR Inhibitor Attenuates HCO3- Secretion And Duodenal Ulcer Formation In Rats. Amer. J. Physiol. GI Liver Physiol. 2005; 289(4): G753-G759.
M. E. Jung and A. R. Novack Formation of 3,4-Dimethyl-2-pyrones from Allene Carboxylates and 2-Silyloxydienes via 3-Carboethoxyethylidene Cyclobutanols. Tetrahedron Lett. 2005; 46(47): 8237-8240.
M. E. Jung and G. Piizzi Gem-Disubstituent Effect: Theoretical Basis and Synthetic Applications. Chem Rev. 2005; 105(5): 1735-1766.
M. E. Jung and S.-J. Min Intramolecular Diels-Alder Reactions of Optically Active Allenic Ketones: Chirality Transfer in the Preparation of Substituted Oxa-bridged Octalones. J. Am. Chem. Soc. 2005; 127(31): 10834-5.
M. E. Jung, J. J. Clemens, N. Suttee, C. K. Liew, and R. T. Clubb Synthesis of (2R, 3S) 3-Amino-4-mercapto-2-butanol, a Threonine Analogue for Covalent Inhibition of Sortases. Bioorg. Med. Chem. Letts. 2005; 15(22): 5076-5079.
M. E. Jung and A. Maderna Synthesis of Bicyclo[2.2.2]oct-5-en-2-ones via a Tandem Intermolecular Michael Addition Intramolecular Aldol Process (a Bridged Robinson Annulation). Tetrahedron Lett. 2005; 46(30): 5057-5061.
Jung, M. E. Ho, D. Chu, H. V. Synthesis of highly substituted cyclohexenes via mixed Lewis acid-catalyzed Diels-Alder reactions of highly substituted dienes and dienophiles. Org Lett. 2005; 7(8): 1649-51.
Jung, M. E. Min, S. J. Houk, K. N. Ess, D. Synthesis and relative stability of 3,5-diacyl-4,5-dihydro-1H-pyrazoles prepared by dipolar cycloaddition of enones and alpha-diazoketones. J Org Chem. 2004; 69(26): 9085-9.
Jung, M. E. Maderna, A. Microwave-assisted allylation of acetals with allyltrimethylsilane in the presence of CuBr. J Org Chem. 2004; 69(22): 7755-7.
J. E. Katz, D. S. Dumlao, J. I. Wasserman, M. G. Lansdown, M. E. Jung, K. F. Faull and S. Clarke 3-Isopropylmalate is the Major Endogenous Substrate of the Saccharomyces cerevisiae trans-Aconitate Methyltransferase. Biochemistry. 2004; 43(20): 5976-86.
M. E. Jung and A. Maderna Allylation of Acetals and Ketals with Allyltrimethylsilane Catalyzed by the Mixed Lewis Acid System AlBr3/CuBr. Tetrahedron Lett. 2004; 45: 5301-04.
M. E. Jung and B. A. Duclos Diastereoselectivity in the Carroll Rearrangement of β-Keto Esters of Tertiary Allylic Alcohols. Tetrahedron Lett. 2004; 45(1): 107-9.
C. K. Liew, B. T. Smith, R. Pilpa, U. Ilangovan, K. M. Connolly, M. E. Jung, and R. T. Clubb Localization and mutagenesis of the sorting signal binding site on sortase A from Staphylococcus aureus. FEBS Lett. 2004; 571(1-3): 221-226.
M. E. Jung and S.-J. Min Novel Formation of a Bridged Bicyclic Furan by Rearrangement of a Tetrahydroxydecalinone. Tetrahedron Lett 2004; 45: 6753-6755.
Jung, M. E. van den Heuvel, A. A tandem non-aldol aldol Mukaiyama aldol reaction. Org Lett. 2003; 5(24): 4705-7.
Jung, M. E. van den Heuvel, A. Leach, A. G. Houk, K. N. Unexpected syn hydride migration in the non-aldol aldol reaction. Org Lett. 2003; 5(19): 3375-8.
Connolly, K. M. Smith, B. T. Pilpa, R. Ilangovan, U. Jung, M. E. Clubb, R. T. Sortase from Staphylococcus aureus does not contain a thiolate-imidazolium ion pair in its active site. J Biol Chem. 2003; 278(36): 34061-5.
Jung, M. E. Hoffmann, B. Rausch, B. Contreras, J. M. Use of hindered silyl ethers as protecting groups for the non-aldol aldol process. Org Lett. 2003; 5(17): 3159-61.
M. E. Jung and J. I. Wasserman Efficient Synthesis of Vinyl Chlorides and/or gem-Dichlorides from Ketones by Treatment with Tungsten Hexachloride. Tetrahedron Lett. 2003; 44(39): 7273-75.
Jung, M. Voit, S. Klimek, J. Surface geometry of three packable and one hybrid composite after finishing. Oper Dent. 2003; 28(1): 53-9.
Y. Nagao, C. Kimura, K. Kozawa, and M. E. Jung Synthesis, Stereochemistry, and Reactions of 2,5-Diphenylsilacyclopentenes. Silicon Chem. 2003; 2(1-2): 99-107.
M. E. Jung and J. Pontillo Synthetic Approach to Analogues of Sclerophytin A. Tetrahedron. 2003; 59(15): 2729-2736.
Leach, A. G. Wang, R. Wohlhieter, G. E. Khan, S. I. Jung, M. E. Houk, K. N. Theoretical elucidation of kinetic and thermodynamic control of radical addition regioselectivity. J Am Chem Soc. 2003; 125(14): 4271-8.
Jung, M. E. Piizzi, G. Synthetic approach to the AB ring system of ouabain. J Org Chem. 2003; 68(7): 2572-82.
Jung, M. E. Piizzi, G. First synthesis of the A/B ring of ouabain. Org Lett. 2003; 5(2): 137-40.
Jung, M. E. Kers, A. Subbanagounder, G. Berliner, J. A. Studies towards the total synthesis of an epoxy isoprostane phospholipid, a potent activator of endothelial cells. Chem Commun (Camb). 2003; 2: 196-7.
Jung, M. E. Davidov, P. Efficient synthesis of a tricyclic BCD analogue of ouabain: Lewis acid catalyzed Diels-Alder reactions of sterically hindered systems. Angew Chem Int Ed Engl. 2002; 41(21): 4125-8.
Jung, M. E. Pontillo, J. Synthetic approach to analogues of the original structure of sclerophytin A. J Org Chem. 2002; 67(19): 6848-51.
M. E. Jung and A. van den Heuvel Diastereoselectivity in non-Aldol Aldol Reactions: Silyl Triflate Promoted Payne Rearrangements. Tetrahedron Lett. 2002; 43(45): 8169-8172.
M. E. Jung, A. Toyota, E. De Clercq, and J. Balzarini Synthesis and Biological Activity of a Series of Methylene-Expanded Oxetanocin Nucleoside Analogues. Monatshefte Chem. 2002; 133(4): 499-520.
Jung, M. E. Piizzi, G. Novel rearrangements of 4-silyl-3-buten-2-ones. J Org Chem. 2002; 67(11): 3911-4.
Jung, M. E. Davidov, P. The first reported anionic oxy retro-ene reaction. Org Lett. 2001; 3(19): 3025-7.
Jung, M. E. Nishimura, N. Enantioselective formal total synthesis of (-)-dysidiolide. Org Lett. 2001; 3(13): 2113-5.
Jung, M. E. Toyota, A. Preparation of 4'-substituted thymidines by substitution of the thymidine 5'-esters. J Org Chem. 2001; 66(8): 2624-35.
Tantillo, D. J. Houk, K. N. Jung, M. E. Origins of stereoselectivity in intramolecular Diels-Alder cycloadditions of dienes and dienophiles linked by ester and amide tethers. J Org Chem. 2001; 66(6): 1938-40.
Jung, M. E. Davidov, P. Conclusive evidence of the trapping of primary ozonides. Org Lett. 2001; 3(4): 627-9.
Cai, H. Strouse, J. Dumlao, D. Jung, M. E. Clarke, S. Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases. Biochemistry. 2001; 40(7): 2210-9.
Jung, M. E. Lee, C. P. Synthesis of a fully functionalized protected C1-C11 fragment for the synthesis of the tedanolides. Org Lett. 2001; 3(3): 333-6.
Jung, M. E. Lee, B. S. Unusual alpha-methylation of alkoxyaryl ketones with higher order methyl cuprate and lithium bromide. J Org Chem. 2000; 65(26): 9241-4.
Choe, S. W. Jung, M. E. Preparation of various C-2 branched carbohydrates using intramolecular radical reactions. Carbohydr Res. 2000; 329(4): 731-44.
Jung, M. E. Huang, A. Use of optically active cyclic N,N-dialkyl aminals in asymmetric induction. Org Lett. 2000; 2(17): 2659-61.
Jung, M. E. Huang, A. Johnson, T. W. Unusual Diastereoselectivity in Intramolecular Diels-Alder Reactions of Substituted 3,5-Hexadienyl Acrylates. Preference for a Boatlike Structure of the Six-Atom Tether Due to Ester Overlap. Org Lett. 2000; 2(13): 1835-1837.
Jung, M. E. Marquez, R. Efficient synthesis of the C(1)-C(11) fragment of the tedanolides. The nonaldol aldol process in synthesis. Org Lett. 2000; 2(12): 1669-72.
Jung, M. E. Fahr, B. T. Novel base-induced [1,2]-acyl shift of allylic esters of cyclopropanecarboxylic acids. J Org Chem. 2000; 65(7): 2239-42.