UCLA Molecular and Medical Pharmacology  









Faculty

Department / Division Affiliations
Member, JCCC Cancer Cell Biology Program Area, JCCC Signal Transduction and Therapeutics Program Area, Crump Institute for Molecular Imaging
Research Fellow, Alfred P. Sloan Foundation
ACCESS Affinity Group:
ACCESS Affinity - Molecular Basis of Disease
Research Interest:
Systems biology of cancer signaling: My group is working to understand cancer signaling from a systems viewpoint. We focus on developing genome- and proteome-wide detection assays, applying these assays to measuring and computationally modeling aberrant cancer signaling, and translating our discoveries to clinical applications. We have developed a quantitative mass spectrometry-based protocol for identifying tyrosine-phosphorylated proteins from cancer cell lysates. We are using this proteome-wide 'phosphorylation profiling' assay to identify the signaling pathways activated by various oncogenic initiating events (e.g. kinase mutations), and to elucidate the interconnectedness of classical signaling pathways into a more comprehensive signaling network. In modeling cancer signaling, one of our goals is to identify minimal sets of informative components that best reflect the state of the cell and serve as molecular targets for diagnostics, imaging, and patient tailored treatment. As with all of systems biology, our research relies on an interdisciplinary approach that merges biology, chemistry, mathematics and computation / bioinformatics .
 

Thomas Graeber, Ph.D.

Email Address:
tgraeber@mednet.ucla.edu

Address:
4338 CNSI
Crump Institute for Molecular Imaging
Box 951770
Los Angeles, CA 90095
UNITED STATES

Address:
4341 CNSI

UNITED STATES

Address:
Office
Crump Institute for Molecular Imaging
California NanoSystems Institute (CNSI), Room 4341
Box 951770
Los Angeles, CA 90095
UNITED STATES

Phone Number:
(310) 206-6122
(310) 206-7054


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Publications:
Skaggs BJ, Gorre M, Ryvkin A, Burgess MR, Xie Y, Han Y , Komisopoulou E, Brown LM, Loo JA, Landaw EM, Sawyers CL, Graeber TG Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants. Proc Natl Acad Sci U S A. 2006; 103(51): 19466-19471.
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Zimman A, Mouillesseaux KP, Le T, Gharavi NM, Ryvkin A, Graeber TG, Chen TT, Watson AD, Berliner JA Vascular Endothelial Growth Factor Receptor 2 Plays a Role in the Activation of Aortic Endothelial Cells by Oxidized Phospholipids. Arterioscler Thromb Vasc Biol. 2007; 01.ATV.0000252842.57585.df.
Graeber TG, Sawyers CL Cross-species comparisons of cancer signaling. Nature genetics. 2005; 37(1): 7-8.
Krutzik SR, Tan B, Li H, Ochoa MT, Liu PT, Sharfstein SE, Graeber TG, Sieling PA, Liu YJ, Rea TH, Bloom BR, Modlin RL TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Nature Medicine . 2005; 11(6): 653-660.
Pellegrini M, Graeber TG Computational methods for protein function analysis. Focus on Protein Research. 2004; .
Ellwood-Yen K, Graeber TG, Wongvipat J, Iruela-Arispe ML, Zhang J, Matusik R, Thomas GV, Sawyers CL Myc-driven murine prostate cancer shares molecular features with human prostate tumors.. Cancer cell.. 2003; 4(3): 223-38.
Bleharski JR, Li H, Meinken C, Graeber TG, Ochoa MT, Yamamura M, Burdick A, Sarno EN, Wagner M, Rollinghoff M, Rea TH, Colonna M, Stenger S, Bloom BR, Eisenberg D, Modlin RL Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science. 2003; 301(5639): 1527-30.
Strong M, Graeber TG, Beeby M, Pellegrini M, Thompson MJ, Yeates TO, Eisenberg D Visualization and interpretation of protein networks in Mycobacterium tuberculosis based on hierarchical clustering of genome-wide functional linkage maps.. Nucleic acids research. . 2003; 31(24): 7099-109.
Matei D, Graeber TG, Baldwin RL, Karlan BY, Rao J, Chang DD Gene expression in epithelial ovarian carcinoma. Oncogene. 2002; 21(41): 6289-98.
Graeber TG, Eisenberg D Bioinformatic identification of potential autocrine signaling loops in cancers from gene expression profiles.. Nature genetics. . 2001; 29(3): 295-300.
Graeber TG, Shuai K Rapid gene repression triggered by interleukin-6 at the onset of monocyte differentiation.. Biochemical and biophysical research communications. . 2000; 267(3): 863-9.
Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours.. Nature. . 1996; 379(6560): 88-91.
Graeber TG, Peterson JF, Tsai M, Monica K, Fornace AJ, Giaccia AJ Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.. Molecular and cellular biology. . 1994; 14(9): 6264-77.