Department / Division Affiliations
|Professor, Molecular & Medical Pharmacology|
|Member, Positron Emission Tomography/Computed Tomography, Santa Monica Nuclear Medicine Services|
Previously developed on validated radiotracer techniques are employed for noninvasively probing blood flow and substrate metabolism in the human heart. On-going research focuses on exploring the regulation of the coronary circulation in the human heart and on the noninvasive characterization of coronary endothelial function as a critical component in the development of atherosclerosis. In particular, research focuses on characterizing the effects of coronary risk factors, of estrogen withdrawal or of diabetes on coronary vasomotion and on defining responses to acute and chronic pharmacologic interventions that alter or restore nitric oxide bioactivity in the human circulation.
Schindler Thomas H, Campisi Roxana, Dorsey Deborah, Prior John O, Olschewski Manfred, Sayre James, Schelbert Heinrich R Effect of hormone replacement therapy on vasomotor function of the coronary microcirculation in post-menopausal women with medically treated cardiovascular risk factors. European heart journal. 2009; 30(8): 978-86.
Campisi R, Czernin J, SchÃ¶der H, Sayre J W, Schelbert H R L-Arginine normalizes coronary vasomotion in long-term smokers. Circulation. 1999; 99(4): 491-7.
Krivokapich J, Smith G T, Huang S C, Hoffman E J, Ratib O, Phelps M E, Schelbert H R 13N ammonia myocardial imaging at rest and with exercise in normal volunteers. Quantification of absolute myocardial perfusion with dynamic positron emission tomography. Circulation. 1989; 80(5): 1328-37.
Tillisch J, Brunken R, Marshall R, Schwaiger M, Mandelkern M, Phelps M, Schelbert H Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. The New England journal of medicine. 1986; 314(14): 884-8.