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Faculty
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Research Interest:
Previously developed on validated radiotracer techniques are employed for noninvasively probing blood flow and substrate metabolism
in the human heart. On-going research focuses on exploring the regulation of the coronary circulation in the human heart and on the
noninvasive characterization of coronary endothelial function as a critical component in the development of atherosclerosis. In particular,
research focuses on characterizing the effects of coronary risk factors, of estrogen withdrawal or of diabetes on coronary vasomotion
and on defining responses to acute and chronic pharmacologic interventions that alter or restore nitric oxide bioactivity in the
human circulation. Other areas of research explore new imaging approaches in the myocardium of small animals with the ultimate
goal of demonstrating noninvasively the expression of therapeutically administered genes and responses in cardiovascular function to
gene therapy.
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Publications:
Campisi, R Czernin, J Schöder, H Sayre, JW Schelbert, HR L-Arginine normalizes coronary vasomotion in long-term smokers..
Circulation. .
1999; 99(4):
491-7.
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