FACULTY RESEARCH

Faculty List

Orian Shirihai, M.D., Ph.D.

Email Address: oshirihai@mednet.ucla.edu

Office Phone Number: 310-825-5160

Mailing Address:
BOX 957073, CHS 33-131E
Los Angeles, CA 90095

Department / Division Affiliations
Chair, and Professor, Endocrinology, Diabetes and Hypertension
Professor, Molecular & Medical Pharmacology
Member, themes


Publications
Montemurro Chiara, Vadrevu Suryakiran, Gurlo Tatyana, Butler Alexandra E, Vongbunyong Kenny E, Petcherski Anton, Shirihai Orian S, Satin Leslie S, Braas Daniel, Butler Peter C, Tudzarova Slavica Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line. Cell cycle (Georgetown, Tex.). 2017; 1-14.
Mahdaviani Kiana, Benador Ilan Y, Su Shi, Gharakhanian Raffi A, Stiles Linsey, Trudeau Kyle M, Cardamone Maria, Enríquez-Zarralanga Violeta, Ritou Eleni, Aprahamian Tamar, Oliveira Marcus F, Corkey Barbara E, Perissi Valentina, Liesa Marc, Shirihai Orian S Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO reports. 2017; 18(7): 1123-1138.
Tkatch Tatiana, Greotti Elisa, Baranauskas Gytis, Pendin Diana, Roy Soumitra, Nita Luliaoana I, Wettmarshausen Jennifer, Prigge Matthias, Yizhar Ofer, Shirihai Orian S, Fishman Daniel, Hershfinkel Michal, Fleidervish Ilya A, Perocchi Fabiana, Pozzan Tullio, Sekler Israel Optogenetic control of mitochondrial metabolism and Ca(2+) signaling by mitochondria-targeted opsins. Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(26): E5167-E5176.
Zeng Chun, Mulas Francesca, Sui Yinghui, Guan Tiffany, Miller Nathanael, Tan Yuliang, Liu Fenfen, Jin Wen, Carrano Andrea C, Huising Mark O, Shirihai Orian S, Yeo Gene W, Sander Maike Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation. Cell metabolism. 2017; 25(5): 1160-1175.e11.
Lim Jeong-A, Li Lishu, Shirihai Orian S, Trudeau Kyle M, Puertollano Rosa, Raben Nina Modulation of mTOR signaling as a strategy for the treatment of Pompe disease. EMBO molecular medicine. 2017; 9(3): 353-370.
Kottakis Filippos, Nicolay Brandon N, Roumane Ahlima, Karnik Rahul, Gu Hongcang, Nagle Julia M, Boukhali Myriam, Hayward Michele C, Li Yvonne Y, Chen Ting, Liesa Marc, Hammerman Peter S, Wong Kwok Kin, Hayes D Neil, Shirihai Orian S, Dyson Nicholas J, Haas Wilhelm, Meissner Alexander, Bardeesy Nabeel LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature. 2016; 539(7629): 390-395.
Trudeau Kyle M, Colby Aaron H, Zeng Jialiu, Las Guy, Feng Jiazuo H, Grinstaff Mark W, Shirihai Orian S Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity. The Journal of cell biology. 2016; 214(1): 25-34.
Deeney Jude T, Belkina Anna C, Shirihai Orian S, Corkey Barbara E, Denis Gerald V BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell. PloS one. 2016; 11(3): e0151329.
Fetterman Jessica L, Holbrook Monica, Flint Nir, Feng Bihua, Bretón-Romero Rosa, Linder Erika A, Berk Brittany D, Duess Mai-Ann, Farb Melissa G, Gokce Noyan, Shirihai Orian S, Hamburg Naomi M, Vita Joseph A Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling. Atherosclerosis. 2016; 247(10): 207-17.
Cerqueira Fernanda M, Chausse Bruno, Baranovski Boris M, Liesa Marc, Lewis Eli C, Shirihai Orian S, Kowaltowski Alicia J Diluted serum from calorie-restricted animals promotes mitochondrial β-cell adaptations and protect against glucolipotoxicity. The FEBS journal. 2016; 283(5): 822-33.