FACULTY RESEARCH

Faculty List

Daniel Braas, Ph.D.

Email Address: dbraas@mednet.ucla.edu

Department / Division Affiliations
Member, themes
Adjunct Assistant Professor, Molecular & Medical Pharmacology


Publications
Hirano Arisa, Braas Daniel, Fu Ying-Hui, Ptáček Louis J FAD Regulates CRYPTOCHROME Protein Stability and Circadian Clock in Mice. Cell reports. 2017; 19(2): 255-266.
Chan Lai N, Chen Zhengshan, Braas Daniel, Lee Jae-Woong, Xiao Gang, Geng Huimin, Cosgun Kadriye Nehir, Hurtz Christian, Shojaee Seyedmehdi, Cazzaniga Valeria, Schjerven Hilde, Ernst Thomas, Hochhaus Andreas, Kornblau Steven M, Konopleva Marina, Pufall Miles A, Cazzaniga Giovanni, Liu Grace J, Milne Thomas A, Koeffler H Phillip, Ross Theodora S, Sánchez-García Isidro, Borkhardt Arndt, Yamamoto Keith R, Dickins Ross A, Graeber Thomas G, Müschen Markus Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017; 542(7642): 479-483.
Graham Nicholas A, Minasyan Aspram, Lomova Anastasia, Cass Ashley, Balanis Nikolas G, Friedman Michael, Chan Shawna, Zhao Sophie, Delgado Adrian, Go James, Beck Lillie, Hurtz Christian, Ng Carina, Qiao Rong, Ten Hoeve Johanna, Palaskas Nicolaos, Wu Hong, Müschen Markus, Multani Asha S, Port Elisa, Larson Steven M, Schultz Nikolaus, Braas Daniel, Christofk Heather R, Mellinghoff Ingo K, Graeber Thomas G Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. Molecular systems biology. 2017; 13(2): 914.
Nagaraj Raghavendra, Sharpley Mark S, Chi Fangtao, Braas Daniel, Zhou Yonggang, Kim Rachel, Clark Amander T, Banerjee Utpal Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation. Cell. 2017; 168(1-2): 210-223.e11.
Momcilovic Milica, Bailey Sean T, Lee Jason T, Fishbein Michael C, Magyar Clara, Braas Daniel, Graeber Thomas, Jackson Nicholas J, Czernin Johannes, Emberley Ethan, Gross Matthew, Janes Julie, Mackinnon Andy, Pan Alison, Rodriguez Mirna, Works Melissa, Zhang Winter, Parlati Francesco, Demo Susan, Garon Edward, Krysan Kostyantyn, Walser Tonya C, Dubinett Steven M, Sadeghi Saman, Christofk Heather R, Shackelford David B Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer. Cell reports. 2017; 18(3): 601-610.
Gu Wen, Gaeta Xavier, Sahakyan Anna, Chan Alanna B, Hong Candice S, Kim Rachel, Braas Daniel, Plath Kathrin, Lowry William E, Christofk Heather R Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State. Cell stem cell. 2016; 19(4): 476-490.
Wolahan Stephanie M, Hirt Daniel, Braas Daniel, Glenn Thomas C Role of Metabolomics in Traumatic Brain Injury Research. Neurosurgery clinics of North America. 2016; 27(4): 465-72.
TeSlaa Tara, Chaikovsky Andrea C, Lipchina Inna, Escobar Sandra L, Hochedlinger Konrad, Huang Jing, Graeber Thomas G, Braas Daniel, Teitell Michael A α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells. Cell metabolism. 2016; 24(3): 485-93.
Buck Michael D, O'Sullivan David, Klein Geltink Ramon I, Curtis Jonathan D, Chang Chih-Hao, Sanin David E, Qiu Jing, Kretz Oliver, Braas Daniel, van der Windt Gerritje J W, Chen Qiongyu, Huang Stanley Ching-Cheng, O'Neill Christina M, Edelson Brian T, Pearce Edward J, Sesaki Hiromi, Huber Tobias B, Rambold Angelika S, Pearce Erika L Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. Cell. 2016; 166(1): 63-76.
Wu Ting-Hsiang, Sagullo Enrico, Case Dana, Zheng Xin, Li Yanjing, Hong Jason S, TeSlaa Tara, Patananan Alexander N, McCaffery J Michael, Niazi Kayvan, Braas Daniel, Koehler Carla M, Graeber Thomas G, Chiou Pei-Yu, Teitell Michael A Mitochondrial Transfer by Photothermal Nanoblade Restores Metabolite Profile in Mammalian Cells. Cell metabolism. 2016; 23(5): 921-9.
Krall Abigail S, Xu Shili, Graeber Thomas G, Braas Daniel, Christofk Heather R Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. Nature communications. 2016; 7(5): 11457.
Li Wei, Cohen Alexa, Sun Yin, Squires Jill, Braas Daniel, Graeber Thomas G, Du Lin, Li Gang, Li Zhen, Xu Xiang, Chen Xufeng, Huang Jiaoti The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma. Molecular cancer research : MCR. 2016; 14(4): 344-53.
Hong Candice Sun, Graham Nicholas A, Gu Wen, Espindola Camacho Carolina, Mah Vei, Maresh Erin L, Alavi Mohammed, Bagryanova Lora, Krotee Pascal A L, Gardner Brian K, Behbahan Iman Saramipoor, Horvath Steve, Chia David, Mellinghoff Ingo K, Hurvitz Sara A, Dubinett Steven M, Critchlow Susan E, Kurdistani Siavash K, Goodglick Lee, Braas Daniel, Graeber Thomas G, Christofk Heather R MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4. Cell reports. 2016; 14(7): 1590-601.
Thai Minh, Thaker Shivani K, Feng Jun, Du Yushen, Hu Hailiang, Ting Wu Ting, Graeber Thomas G, Braas Daniel, Christofk Heather R MYC-induced reprogramming of glutamine catabolism supports optimal virus replication. Nature communications. 2015; 6(7): 8873.
Fu Xudong, Chin Randall M, Vergnes Laurent, Hwang Heejun, Deng Gang, Xing Yanpeng, Pai Melody Y, Li Sichen, Ta Lisa, Fazlollahi Farbod, Chen Chuo, Prins Robert M, Teitell Michael A, Nathanson David A, Lai Albert, Faull Kym F, Jiang Meisheng, Clarke Steven G, Cloughesy Timothy F, Graeber Thomas G, Braas Daniel, Christofk Heather R, Jung Michael E, Reue Karen, Huang Jing 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell metabolism. 2015; 22(3): 508-15.
Chin Randall M, Fu Xudong, Pai Melody Y, Vergnes Laurent, Hwang Heejun, Deng Gang, Diep Simon, Lomenick Brett, Meli Vijaykumar S, Monsalve Gabriela C, Hu Eileen, Whelan Stephen A, Wang Jennifer X, Jung Gwanghyun, Solis Gregory M, Fazlollahi Farbod, Kaweeteerawat Chitrada, Quach Austin, Nili Mahta, Krall Abby S, Godwin Hilary A, Chang Helena R, Faull Kym F, Guo Feng, Jiang Meisheng, Trauger Sunia A, Saghatelian Alan, Braas Daniel, Christofk Heather R, Clarke Catherine F, Teitell Michael A, Petrascheck Michael, Reue Karen, Jung Michael E, Frand Alison R, Huang Jing The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014; 510(7505): 397-401.
Thai Minh, Graham Nicholas A, Braas Daniel, Nehil Michael, Komisopoulou Evangelia, Kurdistani Siavash K, McCormick Frank, Graeber Thomas G, Christofk Heather R Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication. Cell metabolism. 2014; 19(4): 694-701.
Ahler Ethan, Sullivan William J, Cass Ashley, Braas Daniel, York Autumn G, Bensinger Steven J, Graeber Thomas G, Christofk Heather R Doxycycline alters metabolism and proliferation of human cell lines. PloS one. 2013; 8(5): e64561.
Wang Jun, Hwang Kiwook, Braas Daniel, Dooraghi Alex, Nathanson David, Campbell Dean O, Gu Yuchao, Sandberg Troy, Mischel Paul, Radu Caius, Chatziioannou Arion F, Phelps Michael E, Christofk Heather, Heath James R Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013; 54(10): 1820-4.
Smith Kathleen B, Tran Linh M, Tam Brenna M, Shurell Elizabeth M, Li Yunfeng, Braas Daniel, Tap William D, Christofk Heather R, Dry Sarah M, Eilber Fritz C, Wu Hong Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition. The American journal of pathology. 2013; 182(4): 1400-11.
Braas Daniel, Ahler Ethan, Tam Brenna, Nathanson David, Riedinger Mirielle, Benz Matthias R, Smith Kathleen B, Eilber Fritz C, Witte Owen N, Tap William D, Wu Hong, Christofk Heather R Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment. Cancer discovery. 2012; 2(12): 1109-17.
Nagaraj Raghavendra, Gururaja-Rao Shubha, Jones Kevin T, Slattery Matthew, Negre Nicolas, Braas Daniel, Christofk Heather, White Kevin P, Mann Richard, Banerjee Utpal Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway. Genes & development. 2012; 26(18): 2027-37.
Yamkamon Vichanan, Ivanova Olga, Braas Daniel, Chayka Olesya, Patmasiriwat Pimpicha, Klempnauer Karl-Heinz A dual activation mechanism for Myb-responsive genes in myelomonocytic cells. Blood cells, molecules & diseases. 2009; 40(2): 219-26.
Ramirez-Carrozzi Vladimir R, Braas Daniel, Bhatt Dev M, Cheng Christine S, Hong Christine, Doty Kevin R, Black Joshua C, Hoffmann Alexander, Carey Michael, Smale Stephen T A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell. 2009; 138(1): 114-28.
Ivanova Olga, Braas Daniel, Klempnauer Karl-Heinz Oncogenic point mutations in the Myb DNA-binding domain alter the DNA-binding properties of Myb at a physiological target gene. Nucleic acids research. 2007; 35(21): 7237-47.
Gundelach Holger, Braas Daniel, Klempnauer Karl-Heinz The promoter regions of the Myb-regulated Adora2B and Mcm4 genes co-localize with origins of DNA replication. BMC molecular biology. 2007; 8(2): 75.
Chayka Olesya, Kintscher Jörg, Braas Daniel, Klempnauer Karl-Heinz v-Myb mediates cooperation of a cell-specific enhancer with the mim-1 promoter. Molecular and cellular biology. 2005; 25(1): 499-511.
Kintscher Jörg, Yamkamon Vichanan, Braas Daniel, Klempnauer Karl-Heinz Identification of a Myb-responsive enhancer of the chicken C/EBPbeta gene. Oncogene. 2004; 23(34): 5807-14.
Braas Daniel, Gundelach Holger, Klempnauer Karl-Heinz The glioma-amplified sequence 41 gene (GAS41) is a direct Myb target gene. Nucleic acids research. 2004; 32(16): 4750-7.
Braas Daniel, Kattmann Dana, Miethe Josef, Klempnauer Karl Heinz Analysis of DNase I-hypersensitive sites in the chromatin of the chicken adenosine receptor 2B gene reveals multiple cell-type-specific cis-regulatory elements. Gene. 2003; 303(34): 157-64.