FACULTY RESEARCH

Faculty List

Harley Ian Kornblum, M.D., Ph.D.

Work Email Address: harley@ucla.edu

Work Phone Number: (310) 794-7866

Laboratory Address:
635 Charles E. Young Drive South
Los Angeles, CA 90095

Office Address:
Room 341 NRB
635 Charles E. Young Drive south
Los Angeles, CA 90095

Department / Division Affiliations
Professor, Pediatrics
Professor in Residence, Semel Institute for Neuroscience and Human Behavior, Molecular & Medical Pharmacology
Associate Clinical Professor, Pediatric Neurology
Member, ACCESS Program: Dept. of Molecular & Medical Pharmacology, JCCC Cancer and Stem Cell Biology Program Area, Neuroscience IDP, Brain Research Institute, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research

Research Interests
My research focuses on the normal development of the brain and how brain injury can be effectively repaired. Specifically, we are interested in both the fundamental and applied biology of stem cells in the central nervous system. We use a variety of methods to discover what genes are important in stem cell biology, how those genes function, and whether they can be used to aid in the neural repair process in several models of brain injury. A significant part of our program involves in vivo work using newly developed methods of imaging the rodent brain, such as the microPET scanner. We are also interested in how neural stem cells relate to brain tumors and have discovered cells within brain tumors that have many characteristics of neural stem cells. Current work seeks to understand the fundamental biology of these possible "cancer stem cells."


Publications
Geschwind DH, Ou J, Easterday M, Trerskikh A, Weissman I, Chen Z, Nelson S, Kornblum HI A genetic analysis of neural progenitor differentiation.. Neuron 2001; 29: 325-339.
Pope Whitney B, Prins Robert M, Albert Thomas M, Nagarajan Rajakumar, Yen Katharine E, Bittinger Mark A, Salamon Noriko, Chou Arthur P, Yong William H, Soto Horacio, Wilson Neil, Driggers Edward, Jang Hyun G, Su Shinsan M, Schenkein David P, Lai Albert, Cloughesy Timothy F, Kornblum Harley I, Wu Hong, Fantin Valeria R, Liau Linda M Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy.. Journal of neuro-oncology. 2012; 107(1): 197-205.
Liu Yue, Ye Fei, Yamada Kazunari, Tso Jonathan L, Zhang Yibei, Nguyen David H, Dong Qinghua, Soto Horacio, Choe Jinny, Dembo Anna, Wheeler Hayley, Eskin Ascia, Schmid Ingrid, Yong William H, Mischel Paul S, Cloughesy Timothy F, Kornblum Harley I, Nelson Stanley F, Liau Linda M, Tso Cho-Lea Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells.. Molecular cancer research : MCR. 2011; 9(12): 1668-85.
Visnyei Koppany, Onodera Hideyuki, Damoiseaux Robert, Saigusa Kuniyasu, Petrosyan Syuzanna, De Vries David, Ferrari Denise, Saxe Jonathan, Panosyan Eduard H, Masterman-Smith Michael, Mottahedeh Jack, Bradley Kenneth A, Huang Jing, Sabatti Chiara, Nakano Ichiro, Kornblum Harley I A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells.. Molecular cancer therapeutics. 2011; 10(10): 1818-28.
Nakano Ichiro, Joshi Kaushal, Visnyei Koppany, Hu Bin, Watanabe Momoko, Lam Diana, Wexler Eric, Saigusa Kuniyasu, Nakamura Yuko, Laks Dan R, Mischel Paul S, Viapiano Mariano, Kornblum Harley I Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway.. Neuro-oncology. 2011; 13(6): 622-34.
Jijiwa Mayumi, Demir Habibe, Gupta Snehalata, Leung Crystal, Joshi Kaushal, Orozco Nicholas, Huang Tiffany, Yildiz Vedat O, Shibahara Ichiyo, de Jesus Jason A, Yong William H, Mischel Paul S, Fernandez Soledad, Kornblum Harley I, Nakano Ichiro CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway.. PloS one. 2011; 6(9): e24217.
Le Belle Janel E, Orozco Nicolas M, Paucar Andres A, Saxe Jonathan P, Mottahedeh Jack, Pyle April D, Wu Hong, Kornblum Harley I Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner.. Cell stem cell. 2011; 8(1): 59-71.
Neveu Pierre, Kye Min Jeong, Qi Shuping, Buchholz David E, Clegg Dennis O, Sahin Mustafa, Park In-Hyun, Kim Kwang-Soo, Daley George Q, Kornblum Harley I, Shraiman Boris I, Kosik Kenneth S MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states.. Cell stem cell. 2010; 7(6): 671-81.
Panosyan Eduard H, Laks Dan R, Masterman-Smith Michael, Mottahedeh Jack, Yong William H, Cloughesy Timothy F, Lazareff Jorge A, Mischel Paul S, Moore Theodore B, Kornblum Harley I Clinical outcome in pediatric glial and embryonal brain tumors correlates with in vitro multi-passageable neurosphere formation.. Pediatric blood & cancer. 2010; 55(4): 644-51.
Laks Dan Richard, Visnyei Koppany, Kornblum Harley Ian Brain tumor stem cells as therapeutic targets in models of glioma.. Yonsei medical journal. 2010; 51(5): 633-40.
Sun Jing, Masterman-Smith Michael D, Graham Nicholas A, Jiao Jing, Mottahedeh Jack, Laks Dan R, Ohashi Minori, DeJesus Jason, Kamei Ken-ichiro, Lee Ki-Bum, Wang Hao, Yu Zeta T F, Lu Yi-Tsung, Hou Shuang, Li Keyu, Liu Max, Zhang Nangang, Wang Shutao, Angenieux Brigitte, Panosyan Eduard, Samuels Eric R, Park Jun, Williams Dirk, Konkankit Vera, Nathanson David, van Dam R Michael, Phelps Michael E, Wu Hong, Liau Linda M, Mischel Paul S, Lazareff Jorge A, Kornblum Harley I, Yong William H, Graeber Thomas G, Tseng Hsian-Rong A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens.. Cancer research. 2010; 70(15): 6128-38.
Kornblum Harley I A multipronged approach to the identification and study of an important oncogene in GBM.. Cancer cell. 2010; 17(5): 417-8.
Zhong Jin, Chan Albert, Morad Leeron, Kornblum Harley I, Fan Guoping, Carmichael S Thomas Hydrogel Matrix to Support Stem Cell Survival After Brain Transplantation in Stroke.. Neurorehabilitation and neural repair. 2010; .
Shoemaker Lorelei D, Orozco Nicholas M, Geschwind Daniel H, Whitelegge Julian P, Faull Kym F, Kornblum Harley I Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors.. PloS one. 2010; 5(2): e9121.
Lewerenz Jan, Albrecht Philipp, Tien Mai-Ly Tran, Henke Nadine, Karumbayaram Saravanan, Kornblum Harley I, Wiedau-Pazos Martina, Schubert Dave, Maher Pamela, Methner Axel Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro.. Journal of neurochemistry. 2009; 111(2): 332-43.
Wexler Eric M, Paucer Andres, Kornblum Harley I, Palmer Theodore D, Plamer Theodore D, Geschwind Daniel H Endogenous Wnt signaling maintains neural progenitor cell potency.. Stem cells (Dayton, Ohio). 2009; 27(5): 1130-41.
Karumbayaram Saravanan, Kelly Theresa K, Paucar Andres A, Roe Anne J T, Umbach Joy A, Charles Andrew, Goldman Steven A, Kornblum Harley I, Wiedau-Pazos Martina Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS.. Disease models & mechanisms. 2009; 2(3-4): 189-95.
Karumbayaram Saravanan, Novitch Bennett G, Patterson Michaela, Umbach Joy A, Richter Laura, Lindgren Anne, Conway Anne E, Clark Amander T, Goldman Steve A, Plath Kathrin, Wiedau-Pazos Martina, Kornblum Harley I, Lowry William E Directed differentiation of human-induced pluripotent stem cells generates active motor neurons.. Stem cells (Dayton, Ohio). 2009; 27(4): 806-11.
Laks Dan R, Masterman-Smith Michael, Visnyei Koppany, Angenieux Brigitte, Orozco Nicholas M, Foran Ian, Yong William H, Vinters Harry V, Liau Linda M, Lazareff Jorge A, Mischel Paul S, Cloughesy Timothy F, Horvath Steve, Kornblum Harley I Neurosphere formation is an independent predictor of clinical outcome in malignant glioma.. Stem cells (Dayton, Ohio). 2009; 27(4): 980-7.
Kelly Theresa K, Karsten Stanislav L, Geschwind Daniel H, Kornblum Harley I Cell lineage and regional identity of cultured spinal cord neural stem cells and comparison to brain-derived neural stem cells.. PloS one. 2009; 4(1): e4213.
Nakano Ichiro, Kornblum Harley I Methods for analysis of brain tumor stem cell and neural stem cell self-renewal.. Methods in molecular biology (Clifton, N.J.). 2009; 568(6): 37-56.
Gregorian Caroline, Nakashima Jonathan, Le Belle Janel, Ohab John, Kim Rachel, Liu Annie, Smith Kate Barzan, Groszer Matthias, Garcia A Denise, Sofroniew Michael V, Carmichael S Thomas, Kornblum Harley I, Liu Xin, Wu Hong Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009; 29(6): 1874-86.
Ratan Rajiv R, Siddiq Ambreena, Aminova Leila, Langley Brett, McConoughey Stephen, Karpisheva Ksenia, Lee Hsin-Hwa, Carmichael Thomas, Kornblum Harley, Coppola Giovanni, Geschwind Daniel H, Hoke Ahmet, Smirnova Natalya, Rink Cameron, Roy Sashwati, Sen Chandan, Beattie Michael S, Hart Ron P, Grumet Martin, Sun Dongming, Freeman Robert S, Semenza Gregg L, Gazaryan Irina Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.. Annals of the New York Academy of Sciences. 2008; 1147(6): 383-94.
Erickson Rebecca I, Paucar Andres A, Jackson Robert L, Visnyei Koppany, Kornblum Harley Roles of insulin and transferrin in neural progenitor survival and proliferation.. Journal of neuroscience research. 2008; 86(8): 1884-94.
Nakano Ichiro, Saigusa Kuniyasu, Kornblum Harley I BMPing off glioma stem cells.. Cancer cell. 2008; 13(1): 3-4.
Lelievre Vincent, Seksenyan Akop, Nobuta Hiroko, Yong William H, Chhith Seririthanar, Niewiadomski Pawel, Cohen Joseph R, Dong Hongmei, Flores Avegail, Liau Linda M, Kornblum Harley I, Scott Matthew P, Waschek James A Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice.. Developmental biology. 2008; 313(1): 359-70.
Nakano Ichiro, Masterman-Smith Michael, Saigusa Kuniyasu, Paucar Andres A, Horvath Steve, Shoemaker Lorelei, Watanabe Momoko, Negro Alejandra, Bajpai Ruchi, Howes Amy, Lelievre Vincent, Waschek James A, Lazareff Jorge A, Freije William A, Liau Linda M, Gilbertson Richard J, Cloughesy Timothy F, Geschwind Daniel H, Nelson Stanley F, Mischel Paul S, Terskikh Alexey V, Kornblum Harley I Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells.. Journal of neuroscience research. 2008; 86(1): 48-60.
Saxe Jonathan P, Wu Hao, Kelly Theresa K, Phelps Michael E, Sun Yi E, Kornblum Harley I, Huang Jing A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation.. Chemistry & biology. 2007; 14(9): 1019-30.
Nakano Ichiro, Dougherty Joseph D, Kim Kevin, Klement Ivan, Geschwind Daniel H, Kornblum Harley I Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation.. Stem cells (Dayton, Ohio). 2007; 25(8): 1975-84.
Cheng Jerry C, Horwitz Edwin M, Karsten Stanislav L, Shoemaker Lorelei, Kornblum Harley I, Malik Punam, Sakamoto Kathleen M Report on the workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006.. Stem cells (Dayton, Ohio). 2007; 25(4): 1070-88.
Kornblum Harley I Introduction to neural stem cells.. Stroke; a journal of cerebral circulation. 2007; 38(2 Suppl): 810-6.
Liu Tsunglin, Papagiannakopoulos Thales, Puskar Kathy, Qi Shuping, Santiago Fernando, Clay William, Lao Kaiqin, Lee Yohan, Nelson Stanley F, Kornblum Harley I, Doyle Frank, Petzold Linda, Shraiman Boris, Kosik Kenneth S Detection of a microRNA signal in an in vivo expression set of mRNAs.. PloS one. 2007; 2(8): e804.
Nakano Ichiro, Kornblum Harley I Brain tumor stem cells.. Pediatric research. 2006; 59(4 Pt 2): 54R-8R.
Visnyei Koppany, Tatsukawa Keith J, Erickson Rebecca I, Simonian Sharis, Oknaian Nareg, Carmichael S Thomas, Kornblum Harley I Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion.. Experimental neurology. 2006; 197(2): 465-74.
Imura Tetsuya, Nakano Ichiro, Kornblum Harley I, Sofroniew Michael V Phenotypic and functional heterogeneity of GFAP-expressing cells in vitro: differential expression of LeX/CD15 by GFAP-expressing multipotent neural stem cells and non-neurogenic astrocytes.. Glia. 2006; 53(3): 277-93.
Groszer Matthias, Erickson Rebecca, Scripture-Adams Deirdre D, Dougherty Joseph D, Le Belle Janel, Zack Jerome A, Geschwind Daniel H, Liu Xin, Kornblum Harley I, Wu Hong PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry.. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103(1): 111-6.
Nakano Ichiro, Paucar Andres A, Bajpai Ruchi, Dougherty Joseph D, Zewail Amani, Kelly Theresa K, Kim Kevin J, Ou Jing, Groszer Matthias, Imura Tetsuya, Freije William A, Nelson Stanley F, Sofroniew Michael V, Wu Hong, Liu Xin, Terskikh Alexey V, Geschwind Daniel H, Kornblum Harley I Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.. The Journal of cell biology. 2005; 170(3): 413-27.
Fox Irina J, Kornblum Harley I Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions.. Journal of neuroscience research. 2005; 79(5): 584-97.
Fox Irina J, Paucar Andres A, Nakano Ichiro, Mottahedeh Jack, Dougherty Joseph D, Kornblum Harley I Developmental expression of glial fibrillary acidic protein mRNA in mouse forebrain germinal zones--implications for stem cell biology.. Brain research. Developmental brain research. 2004; 153(1): 121-5.
Nakano Ichiro, Hemmati Houman D, Kornblum Harley I [Cancer stem cells in pediatric brain tumors]. No shinkei geka. Neurological surgery. 2004; 32(8): 827-34.
Tiwari-Woodruff Seema K, Kaplan Roman, Kornblum Harley I, Bronstein Jeff M Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily.. Journal of neuroscience research. 2004; 77(2): 166-73.
Carmichael S Thomas, Tatsukawa Keith, Katsman Diana, Tsuyuguchi Naohiro, Kornblum Harley I Evolution of diaschisis in a focal stroke model.. Stroke; a journal of cerebral circulation. 2004; 35(3): 758-63.
Mir Halleh M, Tatsukawa Keith J, Carmichael S Thomas, Chesselet Marie-Francoise, Kornblum Harley I Metabolic correlates of lesion-specific plasticity: an in vivo imaging study.. Brain research. 2004; 1002(1-2): 28-34.
Irvin Dwain K, Nakano Ichiro, Paucar Andreas, Kornblum Harley I Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells.. Journal of neuroscience research. 2004; 75(3): 330-43.
Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.. Developmental biology. . 2003; 264(2): 309-22.
Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI Cancerous stem cells can arise from pediatric brain tumors.. Proceedings of the National Academy of Sciences of the United States of America. . 2003; 100(25): 15178-83.
Hemmati Houman D, Nakano Ichiro, Lazareff Jorge A, Masterman-Smith Michael, Geschwind Daniel H, Bronner-Fraser Marianne, Kornblum Harley I Cancerous stem cells can arise from pediatric brain tumors.. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(25): 15178-83.
Easterday Mathew C, Dougherty Joseph D, Jackson Robert L, Ou Jing, Nakano Ichiro, Paucar Andres A, Roobini Babak, Dianati Mehrnoosh, Irvin Dwain K, Weissman Irving L, Terskikh Alexey V, Geschwind Daniel H, Kornblum Harley I Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.. Developmental biology. 2003; 264(2): 309-22.
Karsten Stanislav L, Kudo Lili C, Jackson Robert, Sabatti Chiara, Kornblum Harley I, Geschwind Daniel H Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks.. Developmental biology. 2003; 261(1): 165-82.
Fu Lijuan, Abu-Khalil Amir, Morrison Richard S, Geschwind Daniel H, Kornblum Harley I Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain.. The Journal of comparative neurology. 2003; 462(2): 265-73.
Irvin Dwain K, Dhaka Ajay, Hicks Carol, Weinmaster Gerry, Kornblum Harley I Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures.. Developmental neuroscience. 2003; 25(2-4): 162-72.
Imura Tetsuya, Kornblum Harley I, Sofroniew Michael V The predominant neural stem cell isolated from postnatal and adult forebrain but not early embryonic forebrain expresses GFAP.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003; 23(7): 2824-32.
Bruce Laura L, Kornblum Harley I, Seroogy Kim B Comparison of thalamic populations in mammals and birds: expression of ErbB4 mRNA.. Brain research bulletin. 2003; 57(3-4): 455-61.
Dhaka Ajay, Costa Rui M, Hu Hailiang, Irvin Dwain K, Patel Apoor, Kornblum Harley I, Silva Alcino J, O'Dell Thomas J, Colicelli John The RAS effector RIN1 modulates the formation of aversive memories.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003; 23(3): 748-57.
Caplan Rochelle, Guthrie Donald, Komo Scott, Siddarth Prabha, Chayasirisobhon Sirichai, Kornblum Harley, Sankar Ramen, Hansen Rebecca, Mitchell Wendy, Shields W Donald Social communication in children with epilepsy.. Journal of child psychology and psychiatry, and allied disciplines. 2002; 43(2): 245-53.
Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X, Wu H Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.. Science. . 2001; 294(5549): 2186-9.
Kornblum HI, Araujo DM, Annala AJ, Tatsukawa KJ, Phelps ME, Cherry SR In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET).. Nature biotechnology. . 2000; 18(6): 655-60.