FACULTY RESEARCH

Faculty List

Tove Olafsen, Ph.D.

Email Address: tolafsen@mednet.ucla.edu
Work Email Address: tolafsen@mednet.ucla.edu

Department / Division Affiliations
Assistant Professor, Molecular & Medical Pharmacology


Publications

A selected list of publications:

D'Souza Jimson W, Hensley Harvey, Doss Mohan, Beigarten Charles, Torgov Michael, Olafsen Tove, Yu Jian Q, Robinson Matthew K   Cerenkov Luminescence Imaging as a Modality to Evaluate Antibody-Based PET Radiotracers Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2017; 58(1): 175-180.
Tavaré Richard, McCracken Melissa N, Zettlitz Kirstin A, Salazar Felix B, Olafsen Tove, Witte Owen N, Wu Anna M   Immuno-PET of Murine T Cell Reconstitution Postadoptive Stem Cell Transplantation Using Anti-CD4 and Anti-CD8 Cys-Diabodies Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2015; 56(8): 1258-64.
Örbom Anders, Ahlstedt Jonas, Serén Tom, Auterinen Iiro, Kotiluoto Petri, Hauge HÃ¥vard, Östlund Karl, Olafsen Tove, Wu Anna M, Dahlbom Magnus, Strand Sven-Erik   Characterization of a double-sided silicon strip detector autoradiography system Medical physics, 2015; 42(2): 575-84.
Williams Lawrence E, Wu Anna M, Kenanova Vania E, Olafsen Tove, Yazaki Paul J   Numerical comparison of iodine-based and indium-based antibody biodistributions Cancer biotherapy & radiopharmaceuticals, 2014; 29(3): 91-8.
Tavaré Richard, McCracken Melissa N, Zettlitz Kirstin A, Knowles Scott M, Salazar Felix B, Olafsen Tove, Witte Owen N, Wu Anna M   Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo Proceedings of the National Academy of Sciences of the United States of America, 2014; 111(3): 1108-13.
Fu Maoyong, Brewer Sarah, Olafsen Tove, Wu Anna M, Gordon Lynn K, Said Jonathan, Braun Jonathan, Wadehra Madhuri   Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 2013; 15(1): 68-78.
Widney Daniel P, Olafsen Tove, Wu Anna M, Kitchen Christina M R, Said Jonathan W, Smith Jeffrey B, Peña Guadalupe, Magpantay Larry I, Penichet Manuel L, Martinez-Maza Otoniel   Levels of murine, but not human, CXCL13 are greatly elevated in NOD-SCID mice bearing the AIDS-associated Burkitt lymphoma cell line, 2F7 PloS one, 2013; 8(8): e72414.
Andersen Jan Terje, Foss Stian, Kenanova Vania E, Olafsen Tove, Leikfoss Ingvild S, Roopenian Derry C, Wu Anna M, Sandlie Inger   Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life The Journal of biological chemistry, 2012; 287(27): 22927-37.
Olafsen Tove   Fc engineering: serum half-life modulation through FcRn binding Methods in molecular biology (Clifton, N.J.), 2012; 907(3): 537-56.
Olafsen Tove, Sirk Shannon J, Olma Sebastian, Shen Clifton K-F, Wu Anna M   ImmunoPET using engineered antibody fragments: fluorine-18 labeled diabodies for same-day imaging Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2012; 33(3): 669-77.
Girgis Mark D, Olafsen Tove, Kenanova Vania, McCabe Katelyn E, Wu Anna M, Tomlinson James S   Targeting CEA in Pancreas Cancer Xenografts with a Mutated scFv-Fc Antibody Fragment EJNMMI research, 2011; 1(1): 24.
Girgis Mark D, Kenanova Vania, Olafsen Tove, McCabe Katelyn E, Wu Anna M, Tomlinson James S   Anti-CA19-9 diabody as a PET imaging probe for pancreas cancer The Journal of surgical research, 2011; 170(2): 169-78.
Olafsen Tove, Elgqvist Jorgen, Wu Anna M   Protein targeting constructs in alpha therapy Current radiopharmaceuticals, 2011; 4(3): 197-213.
Barat Bhaswati, Kenanova Vania E, Olafsen Tove, Wu Anna M   Evaluation of two internalizing carcinoembryonic antigen reporter genes for molecular imaging Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 2011; 13(3): 526-535.
Girgis Mark D, Olafsen Tove, Kenanova Vania, McCabe Katelyn E, Wu Anna M, Tomlinson James S   CA19-9 as a Potential Target for Radiolabeled Antibody-Based Positron Emission Tomography of Pancreas Cancer International journal of molecular imaging, 2011; 2011(4): 834515.
Morizono Kouki, Xie Yiming, Olafsen Tove, Lee Benhur, Dasgupta Asim, Wu Anna M, Chen Irvin S Y   The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry Cell host & microbe, 2011; 9(4): 286-98.
Olafsen Tove, Young Stephen G, Davies Brandon S J, Beigneux Anne P, Kenanova Vania E, Voss Constance, Young Glen, Wong Koon-Pong, Barnes Richard H, Tu Yiping, Weinstein Michael M, Nobumori Chika, Huang Sung-Cheng, Goldberg Ira J, Bensadoun André, Wu Anna M, Fong Loren G   Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning The Journal of biological chemistry, 2010; 285(50): 39239-48.
Kenanova Vania E, Olafsen Tove, Salazar Felix B, Williams Lawrence E, Knowles Scott, Wu Anna M   Tuning the serum persistence of human serum albumin domain III:diabody fusion proteins Protein engineering, design & selection : PEDS, 2010; 23(10): 789-98.
Lepin Eric J, Leyton Jeffrey V, Zhou Yu, Olafsen Tove, Salazar Felix B, McCabe Katelyn E, Hahm Scott, Marks James D, Reiter Robert E, Wu Anna M   An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors European journal of nuclear medicine and molecular imaging, 2010; 37(8): 1529-38.
Olafsen Tove, Wu Anna M   Antibody vectors for imaging Seminars in nuclear medicine, 2010; 40(3): 167-81.
Olafsen Tove, Sirk Shannon J, Betting David J, Kenanova Vania E, Bauer Karl B, Ladno Waldemar, Raubitschek Andrew A, Timmerman John M, Wu Anna M   ImmunoPET imaging of B-cell lymphoma using 124I-anti-CD20 scFv dimers (diabodies) Protein engineering, design & selection : PEDS, 2010; 23(4): 243-9.
Afshar Sepideh, Olafsen Tove, Wu Anna M, Morrison Sherie L   Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT Journal of experimental & clinical cancer research : CR, 2009; 28(4): 147.
Olafsen Tove, Betting David, Kenanova Vania E, Salazar Felix B, Clarke Pat, Said Jonathan, Raubitschek Andrew A, Timmerman John M, Wu Anna M   Recombinant anti-CD20 antibody fragments for small-animal PET imaging of B-cell lymphomas Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2009; 50(9): 1500-8.
Barat Bhaswati, Sirk Shannon J, McCabe Katelyn E, Li Jianqing, Lepin Eric J, Remenyi Roland, Koh Ai Leen, Olafsen Tove, Gambhir Sanjiv S, Weiss Shimon, Wu Anna M   Cys-diabody quantum dot conjugates (immunoQdots) for cancer marker detection Bioconjugate chemistry, 2009; 20(8): 1474-81.
Vaidyanathan Ganesan, Jestin Emmanuelle, Olafsen Tove, Wu Anna M, Zalutsky Michael R   Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK Nuclear medicine and biology, 2009; 36(6): 671-80.
Leyton Jeffrey V, Olafsen Tove, Sherman Mark A, Bauer Karl B, Aghajanian Patrick, Reiter Robert E, Wu Anna M   Engineered humanized diabodies for microPET imaging of prostate stem cell antigen-expressing tumors Protein engineering, design & selection : PEDS, 2009; 22(3): 209-16.
Kenanova Vania, Barat Bhaswati, Olafsen Tove, Chatziioannou Arion, Herschman Harvey R, Braun Jonathan, Wu Anna M   Recombinant carcinoembryonic antigen as a reporter gene for molecular imaging European journal of nuclear medicine and molecular imaging, 2009; 36(1): 104-14.
Sirk Shannon J, Olafsen Tove, Barat Bhaswati, Bauer Karl B, Wu Anna M   Site-specific, thiol-mediated conjugation of fluorescent probes to cysteine-modified diabodies targeting CD20 or HER2 Bioconjugate chemistry, 2008; 19(12): 2527-34.
Gratton Stephanie E A, Williams Stuart S, Napier Mary E, Pohlhaus Patrick D, Zhou Zhilian, Wiles Kenton B, Maynor Benjamin W, Shen Clifton, Olafsen Tove, Samulski Edward T, Desimone Joseph M   The pursuit of a scalable nanofabrication platform for use in material and life science applications Accounts of chemical research, 2008; 41(12): 1685-95.
Wu Anna M, Olafsen Tove   Antibodies for molecular imaging of cancer Cancer journal (Sudbury, Mass.), 2008; 14(3): 191-7.
Wei Liu H, Olafsen Tove, Radu Caius, Hildebrandt Isabel J, McCoy Mark R, Phelps Michael E, Meares Claude, Wu Anna M, Czernin Johannes, Weber Wolfgang A   Engineered antibody fragments with infinite affinity as reporter genes for PET imaging Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2008; 49(11): 1828-35.
Venisnik Katy M, Olafsen Tove, Gambhir Sanjiv S, Wu Anna M   Fusion of Gaussia luciferase to an engineered anti-carcinoembryonic antigen (CEA) antibody for in vivo optical imaging Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 2008; 9(5): 267-77.
Leyton Jeffrey V, Olafsen Tove, Lepin Eric J, Hahm Scott, Bauer Karl B, Reiter Robert E, Wu Anna M   Humanized radioiodinated minibody for imaging of prostate stem cell antigen-expressing tumors Clinical cancer research : an official journal of the American Association for Cancer Research, 2008; 14(22): 7488-96.
Olafsen Tove, Gu Zhennan, Sherman Mark A, Leyton Jeffrey V, Witkosky Michael E, Shively John E, Raubitschek Andrew A, Morrison Sherie L, Wu Anna M, Reiter Robert E   Targeting, imaging, and therapy using a humanized antiprostate stem cell antigen (PSCA) antibody Journal of immunotherapy (Hagerstown, Md. : 1997), 2008; 30(4): 396-405.
Cai Weibo, Olafsen Tove, Zhang Xianzhong, Cao Qizhen, Gambhir Sanjiv S, Williams Lawrence E, Wu Anna M, Chen Xiaoyuan   PET imaging of colorectal cancer in xenograft-bearing mice by use of an 18F-labeled T84.66 anti-carcinoembryonic antigen diabody Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2007; 48(2): 304-10.
Kenanova Vania, Olafsen Tove, Williams Lawrence E, Ruel Nora H, Longmate Jeffrey, Yazaki Paul J, Shively John E, Colcher David, Raubitschek Andrew A, Wu Anna M   Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy Cancer research, 2007; 67(2): 718-26.
Venisnik Katy M, Olafsen Tove, Loening Andreas M, Iyer Meera, Gambhir Sanjiv S, Wu Anna M   Bifunctional antibody-Renilla luciferase fusion protein for in vivo optical detection of tumors Protein engineering, design & selection : PEDS, 2006; 19(10): 453-60.
Olafsen Tove, Kenanova Vania E, Wu Anna M   Tunable pharmacokinetics: modifying the in vivo half-life of antibodies by directed mutagenesis of the Fc fragment Nature protocols, 2006; 1(4): 2048-60.
Olafsen Tove, Kenanova Vania E, Sundaresan Gobalakrishnan, Anderson Anne-Line, Crow Desiree, Yazaki Paul J, Li Lin, Press Michael F, Gambhir Sanjiv S, Williams Lawrence E, Wong Jeffrey Y C, Raubitschek Andrew A, Shively John E, Wu Anna M   Optimizing radiolabeled engineered anti-p185HER2 antibody fragments for in vivo imaging Cancer research, 2005; 65(13): 5907-16.
Kenanova Vania, Olafsen Tove, Crow Desiree M, Sundaresan Gobalakrishnan, Subbarayan Murugesan, Carter Nora H, Ikle David N, Yazaki Paul J, Chatziioannou Arion F, Gambhir Sanjiv S, Williams Lawrence E, Shively John E, Colcher David, Raubitschek Andrew A, Wu Anna M   Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments Cancer research, 2005; 65(2): 622-31.
Olafsen Tove, Tan Giselle J, Cheung Chia-Wei, Yazaki Paul J, Park Jinha M, Shively John E, Williams Lawrence E, Raubitschek Andrew A, Press Michael F, Wu Anna M   Characterization of engineered anti-p185HER-2 (scFv-CH3)2 antibody fragments (minibodies) for tumor targeting Protein engineering, design & selection : PEDS, 2004; 17(4): 315-23.
Olafsen Tove, Cheung Chia-Wei, Yazaki Paul J, Li Lin, Sundaresan Gobalakrishnan, Gambhir Sanjiv S, Sherman Mark A, Williams Lawrence E, Shively John E, Raubitschek Andrew A, Wu Anna M   Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications Protein engineering, design & selection : PEDS, 2004; 17(1): 21-7.
Li Lin, Olafsen Tove, Anderson Anne-Line, Wu Anna, Raubitschek Andrew A, Shively John E   Reduction of kidney uptake in radiometal labeled peptide linkers conjugated to recombinant antibody fragments. Site-specific conjugation of DOTA-peptides to a Cys-diabody Bioconjugate chemistry, 2004; 13(5): 985-95.
Onda Masanori, Olafsen Tove, Tsutsumi Yasuo, Bruland ØS Øyvind S., Pastan Ira   Cytotoxicity of Antiosteosarcoma Recombinant Immunotoxins Composed of TP-3 Fv Fragments and a Truncated Pseudomonas Exotoxin A Journal of immunotherapy : official journal of the Society for Biological Therapy, 2001; 24(2): 144-150.