FACULTY RESEARCH

Faculty List

Jennifer Murphy, Ph.D.

Email Address: jmmurphy@mednet.ucla.edu
Work Email Address: jmmurphy@mednet.ucla.edu

Office Phone Number: (310) 825-7548

Murphy Research Group

Laboratory Address:
CNSI 4310, Crump Institute for Molecular Imaging
Los Angeles, CA 90095

Office Address:
CNSI 4321, Crump Institute for Molecular Imaging
570 Westwood Plaza
Los Angeles, CA 90095

Department / Division Affiliations
Member, Molecular Pharmacology GPB Home Area, Physics & Biology in Medicine GPB Home Area
Faculty, Crump Institute for Molecular Imaging, Molecular & Medical Pharmacology


Publications

A selected list of publications:

Levandowski, B.J.; Gamache, R.F.; Murphy, J.M.*; Houk, K.N.*   Readily accessible ambiphilic cyclopentadienes for bioorthogonal labeling, J. Am. Chem. Soc, 2018; 140: 6426-6431.
Tao, H.; Liu, F.; Zheng, R.; Shao, Z.; Zou, L.; Cao, Y.; Murphy, J.M.; Houk, K.N.; Liang, Y.   Origins of halogen effects in bioorthogonal sydnone cycloadditions, Chem. Commun, 2018; 54: 5082-5085.
Collins, J.; Waldmann, C.M.; Drake, C.; Slavik, R.; Ha, N.S.; Sergeev, M.; Lazari, M.; Shen, B.; Chin, F.T.; Moore, M.; Sadeghi, S.; Phelps, M.E.; Murphy, J.M.; van Dam, R.M.   Production of diverse PET probes with limited resources: 24 18F-labeled compounds prepared with a single radiosynthesizer, Proc. Natl. Acad. Sci. U.S.A. , 2017; 114: 11309-11314.
Narayanam, M.K.; Ma, G.; Champagne, P.A.; Houk, K.N.; Murphy, J.M.   Synthesis of [18F]fluorarenes via nucleophilic radiofluorination of N-arylsydnones, Angew. Chem. Int. Ed. , 2017; 56: 13006-13010.
Hoover, A.J.; Lazari, M.; Ren, H.; Narayanam, M.K.; Murphy, J.M.; van Dam, R.M.; Hooker, J.M.; Ritter, T.   A transmetalation reaction enables the synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging, Organometallics , 2016; 35: 1008-1014.
Gamache, R.F; Waldmann, C.; Murphy, J.M.   Copper-mediated oxidative fluorination of aryl stannanes with fluoride, Org. Lett. , 2016; 18: 4522-4525.
Narayanam, M.K.; Liang, Y.; Houk, K.N.; Murphy, J.M.   Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening, Chem. Sci. , 2016; 7: 1257-1261.
Lazari, M.; Lyashchenko, S.K.; Burnazi, E.M.; Lewis, J.S.; van Dam, R.M.; Murphy, J.M.   Fully-automated synthesis of 16β-18F-Fluoro-5α-dihydrotestosterone (18F-FDHT) on the ELIXYS radiosynthesizer, Appl. Radiat. Isot. , 2015; 103: 9-14.
David A. Nathanson; Amanda L. Armijo; Michelle Tom; Zheng Li; Elizabeth Dimitrova; Wayne R. Austin; Julian Nomme; Dean O. Campbell; Lisa Ta; Thuc M. Le; Jason T. Lee; Ryan Darvish; Ari Gordin; Liu Wei; Hsiang-I Liao; Moses Wilks; Colette Martin; Saman Sadeghi; Jennifer M. Murphy; Nidal Boulos; Michael E. Phelps; Johannes Czernin; Arnon Lavie; Caius G. Radu   Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication, J. Exp. Med, 2014; 211: 473-486.
Julian Nomme; Jennifer M. Murphy; Ying Su; Natasha D. Sansone; Amanda L. Armijo; Steven T. Olson; Caius G. Radu; Arnon Lavie   Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity determining moieties of the molecules, Acta Cryst, 2014; D70: 68-78.
Anthony R. Mazzotti, Michael G. Campbell, Pingping Tang, Jennifer M. Murphy, Tobias Ritter   Palladium(III)-catalyzed fluorination of arylboronic acid derivatives, Journal of the American Chemical Society, 2013; 135(38): 14012-14015.
Jennifer M. Murphy; Amanda L. Armijo; Julian Nomme; Chi Hang Lee; Quentin A. Smith; Zheng Li; Dean O. Campbell; Hsiang-I Liao; David A. Nathanson; Wayne R. Austin; Jason T. Lee; Ryan Darvish; Liu Wei; Jue Wang; Ying Su; Robert Damoiseaux; Saman Sadeghi; Michael E. Phelps; Harvey R. Herschman; Johannes Czernin; Anastassia N. Alexandrova; Michael E. Jung; Arnon Lavie; Caius G. Radu   Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography, Journal of Medicinal Chemistry, 2013; 56(17): 6696-6708.
Michael E. Jung, Jennifer M. Murphy   Functional group selectivity in reactions of epoxides with tungsten hexachloride, Tetrahedron Letters, 2007; 48(47): 8388-8391.