Faculty List

Wei Wei, Ph.D.

Email Address: weiwei@mednet.ucla.edu
Work Email Address: wwei@systemsbiology.org

Work Phone Number: 310-825-9488

Wei Lab

Mailing Address:
Institute for Systems Biology
401 Terry Ave N
Seattle, WA 98109

Department / Division Affiliations
Member, Jonsson Comprehensive Cancer Center
Assistant Professor, Molecular & Medical Pharmacology

Research Interests
The Wei Lab moved to the Insitute for Systems Biology at Seattle in August 2018. Please visit (http://www.wei-lab.net) for more details. My research resides in a highly cross-disciplinary field of BioMEMS,single-cell biology and oncology. Currently focusing on: 1) Single-cell multi-omics tools and associated multivariate computational approaches for interrogating the heterogeneous tumor cells and immune cells at multiple bimolecular levels; 2) Epigenetic remodeling and signaling network dynamics associated with cell state transition and resistance development in epigenetically plastic tumors; 3)Liquid biopsy-based rare cell analysis for cancer metastasis and immunotherapy.


A selected list of publications:

Shao Shiqun, Li Zhonghan, Cheng Hanjun, Wang Siwen, Perkins Nicole G, Sarkar Priyanka, Wei Wei, Xue Min   A Chemical Approach for Profiling Intracellular AKT Signaling Dynamics from Single Cells Journal of the American Chemical Society, 2018; .
Li Zhonghan, Cheng Hanjun, Shao Shiqun, Lu Xiang, Mo Li, Tsang Jonathan, Zeng Pu, Guo Zhili, Wang Siwen, Nathanson David A, Heath James R, Wei Wei*, Xue Min*   Surface Immobilization of Redox-Labile Fluorescent Probes: Enabling Single-Cell Co-Profiling of Aerobic Glycolysis and Oncogenic Protein Signaling Activities Angewandte Chemie (International ed. in English), 2018; 57(36): 11554-11558 (*: co-corresponding authors)..
Yin Tang, Zhuo Wang, Jungwoo Kim, Ziming Li, Yuliang Deng, Yan Li, James R. Heath, Wei Wei*, Shun Lu*, Qihui Shi*   High Throughput Screening of Rare Metabolically Active Tumor Cells in Pleural Effusion and Peripheral Blood of Lung Cancer Patients Proc. Natl. Acad. Sci. U.S.A, 2017; 114(10): 2544-2549 (*: co-corresponding authors).
Yao Lu, Liu Yang, Wei Wei*, Qihui Shi*   Microchip-Based Single-Cell Functional Proteomics for Biomedical Applications Lab on a Chip , 2017; 17: 1250-1263 (*: co-corresponding authors).
Yapeng Su, Qihui Shi*, Wei Wei*   Single Cell Proteomics in Biomedicine: High-dimensional Data Acquisition, Visualization and Analysis Proteomics, 2017; 17(3-4): 1600267 (*:co-corresponding authors).
Yapeng Su†, Wei Wei†*, Lidia Robert†, Min Xue, Jennifer, Angel Garcia-Diaz, Blanca Homet Moreno, Jungwoo Kim, Rachel H.Y. Ng, Jihoon W. Lee, Richard C. Koya, Begonya Comin-Anduix, Thomas G. Graeber, Antoni Ribas*, James R. Heath*   Single cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance Proc. Natl. Acad. Sci. U.S.A, , 2017; 114: 13679-13684 (†: co-first authors; *: co-corresponding authors).
Wei Wei, Young Shik Shin, Min Xue, Tomoo Matsutani, Kenta Masui, Huijun Yang, Shiro Ikegami, Yuchao Gu, Hermann Ken, Dazy Johnson, Xiangming Ding, Kiwook Hwang, Jungwoo Kim, Jian Zhou, Yapeng Su, Xinmin Li, Bruno Bonetti, Rajesh Chopra, C. David James, Webster K. Cavenee, Timothy F. Cloughesy, Paul S. Michel, James R. Heath, Beatrice Gini   Single cell phosphoproteomics resolves adaptive signaling dynamics and informs targeted combination therapy in glioblastoma Cancer Cell, 2016; 29(4): 563-573.
Liu Yang, Zhihua Wang, Yuliang Deng, Yan Li*, Wei Wei*, Qihui Shi*   Single-Cell, Multiplexed Protein Detection of Rare Tumor Cells Based on a Beads-on-Barcode Antibody Microarray Analytical Chemistry, 2016; 88(22): 11077-11083 (*: co-corresponding authors).
Min Xue, Wei Wei, Yapeng Su, Dazy Johnson, James R. Heath   Supramolecular Probes for Assessing Glutamine Uptake Enable Semi-Quantitative Metabolic Models in Single Cells Journal of the American Chemical Society, 2016; 138(9): 3085–3093.
Min Xue*, Wei Wei*, Yapeng Su, Jungwoo Kim, Young Shik Shin, Wilson X. Mai, David A. Nathanson and James, R. Heath   Chemical Methods for the Simultaneous Quantitation of Metabolitesand Proteins from Single Cells Journal of the American Chemical Society, 2015; 137: 4066–-4069;*Equal Contribution.
Yu Zhang, Yin Tang, Shuai Sun, Zhihua Wang, Wenjun Wu, Xiaodong Zhao, Daniel M. Czajkowsky, Yan Li, Jianhui Tian, Ling Xu, Wei Wei, Yuliang Deng, and Qihui Shi   Single-Cell Codetection of Metabolic Activity, Intracellular Functional Proteins, and Genetic Mutations from Rare Circulating Tumor Cells Analytical Chemistry, 2015; 87(19): 9761-9768.
Yuliang Deng, Yu Zhang, Shuai Sun, Zhihua Wang, Minjiao Wang, Beiqin Yu, Daniel M. Czajkowsky, Bingya Liu, Yan Li, Wei Wei, Qihui Shi   An Integrated Microfluidic Chip System for Single-Cell Secretion Profiling of Rare Circulating Tumor Cells Scientific Reports, 2014; 4: 7499.
Yi Jing, Xinyu Bao, Wei Wei, Chun Li, Ke Sun, David P. R. Aplin, Yang Ding, Zhong-Lin Wang, Yoshio Bando, Deli Wang   Catalyst-Free Heteroepitaxial MOCVD Growth of InAs Nanowires on Si Substrates Journal of Physical Chemistry C, 2014; 118: 1696-1705.
Jing Yu, Jing Zhou, Alex Sutherland, Wei Wei, Young Shik Shin, Min Xue, James R Heath   Microfluidics-Based Single-Cell Functional Proteomics for Fundamental and Applied Biomedical Applications Annual Reviews of Analytical Chemistry, 2014; 7: 275-295.
Wei Wei, Qihui Shi, Francoise Remacle, Lidong Qin, David B Shackelford, Young Shik Shin, Paul S Mischel, RD Levine, James R Heath   Hypoxia induces a phase transition within a kinase signaling network in cancer cells Proceedings of the National Academy of Sciences of the United States of America, 2013; 110: E1352-E1360.
Wei Wei, Young Shik Shin, Chao Ma, Jun Wang, Meltem Elitas, Rong Fan, James R Heath   Microchip platforms for multiplex single-cell functional proteomics with applications to immunology and cancer research Genome medicine, 2013; 5: 75.
Jun Wang, Douglas Tham, Wei Wei, Young Shik Shin, Chao Ma, Habib Ahmad, Qihui Shi, Jenkan Yu, Raphael D Levine, James R Heath   Quantitating cell–cell interaction functions with applications to glioblastoma multiforme cancer cells Nano Letters, 2012; 12: 6101–6106.
Qihui Shi, Lidong Qin, Wei Wei, Feng Geng, Rong Fan, Young Shik Shin, Deliang Guo, Leroy Hood, Paul S Mischel, James R Heath   Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells Proceedings of the National Academy of Sciences of the United States of America, 2012; 109: 419-424.
Tingbin Yang, Ke Sun, Xilan Liu, Wei Wei, Tianzhi Yu, Xiong Gong, Deli Wang, Yong Cao   Zinc Oxide Nanowire As an Electron-Extraction Layer for Broadband Polymer Photodetectors with an Inverted Device Structure The Journal of Physical Chemistry C, 2012; 116: 13650–13653.
Ke Sun*, Wei Wei*, Yong Ding, Yi Jing, Zhong Lin Wang, Deli Wang   Crystalline ZnO thin film by hydrothermal growth Chemical Communications, 2011; 47: 7776-7778;*Equal Contribution.
Young Shik Shin, Françoise Remacle, Rong Fan, Kiwook Hwang, Wei Wei, Habib Ahmad, RD Levine, James R Heath   Protein signaling networks from single cell fluctuations and information theory profiling Biophysical journal, 2011; 100: 2378-2386.
Wei Wei, Xin-Yu Bao, Cesare Soci, Yong Ding, Zhong-Lin Wang, Deli Wang   Direct heteroepitaxy of vertical InAs nanowires on Si substrates for broad band photovoltaics and photodetection Nano Letters, 2009; 8: 2926-2934.
Xin-Yu Bao, Cesare Soci, Darija Susac, Jon Bratvold, David PR Aplin, Wei Wei, Ching-Yang Chen, Shadi A Dayeh, Karen L Kavanagh, Deli Wang   Heteroepitaxial growth of vertical GaAs nanowires on Si (111) substrates by metal− organic chemical vapor deposition Nano Letters, 2008; 8: 3755–3760.
Yang Wei, Wei Wei, Liang Liu, Shoushan Fan   Mounting multi-walled carbon nanotubes on probes by dielectrophoresis Diamond and Related Materials, 2008; 17: 1877-1880.
Wei Wei, Yang Liu, Yang Wei, Kaili Jiang, Lian-Mao Peng, Shoushan Fan   Tip cooling effect and failure mechanism of field-emitting carbon nanotubes Nano Letters, 2007; 7: 64-68.
Wei Wei, Kaili Jiang, Yang Wei, Peng Liu, Kai Liu, Lina Zhang, Qunqing Li, Shoushan Fan   LaB 6 tip-modified multiwalled carbon nanotube as high quality field emission electron source Applied Physics Letters, 2006; 89: 203112.
Wei Wei, Kaili Jiang, Yang Wei, Ming Liu, Haitao Yang, Lina Zhang, Qunqing Li, Liang Liu, Shoushan Fan   Measuring the stress in field-emitting carbon nanotubes Nanotechnology, 2006; 17: 1994-1998.