FACULTY RESEARCH

Faculty List

Harvey Roy Herschman, Ph.D.

Work Email Address: hherschman@mednet.ucla.edu

Fax Number: (310) 825-1447

Office Phone Number: (310) 825-8735
(310) 825-8745

Office Address:
341 Boyer Hall (MBI), 611 Charles E. Young Drive East
Los Angeles, CA 90095

Department / Division Affiliations
Director, Molecular Pharmacology GPB Home Area
Distinguished Research Professor, Biological Chemistry
Ralph and Marjorie Crump Distinguished Professor, Molecular & Medical Pharmacology
Vice Chair, Molecular & Medical Pharmacology
Member, CTSI, Crump Institute for Molecular Imaging, JCCC Cancer Molecular Imaging, Molecular Biology Institute, themes

Research Interests
We study how extracellular stimuli elicit changes in cell growth and differentiation, as a result of induced transcription of "primary response" genes. One gene we discovered encodes a second form of cyclooxygenase (COX-2), the rate limiting enzyme in prostaglandin production and the target of a new generation of anti-inflammatory, anti-pyretic and analgesic pharmaceutical agents. We also identified synaptotagmin 4 as a depolarization-induced neuronal gene; a candidate for a mediator of depolarization-induced synaptic plasticity. We have also merged principles of cell biology, molecular biology and molecular imaging technologies to develop procedures that repetitively, non-invasively and quantitatively image reporter gene expression in intact, living animals. More recently, we have demonstrated (1) that Hexokinase 2 and hexokinase 1 (HK2 and HK1) are redundant for glycolysis in most cancers, and that HK2 cannot serve as a target for cancer therapy in these tumors. However (2), in tumors that do not express HK1 and only express HK2, that HK2, in combination with other metabolic enzymes, is targetable for cancer therapy.


Publications
Xu Shili, Catapang Arthur, Braas Daniel, Stiles Linsey, Doh Hanna M, Lee Jason T, Graeber Thomas G, Damoiseaux Robert, Shirihai Orian, Herschman Harvey R A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers. Cancer & metabolism. 2018; 6: 7.
Xu, S., Catapang, A., Doh, H.M., Bayley, N.A., Lee, J.T., Braas, D., Graeber, T.G., Herschman, H.R. Hexokinase-2 is targetable for HK1 negative, HK2 positive tumors from a wide variety of tissues of origin. J. Nucl. Med 2018; 59: .
Lin Meng-Chieh, Chen Shih-Yin, He Pei-Lin, Herschman Harvey, Li Hua-Jung PGE. International journal of cancer. 2018; 143(6): 1440-1455.
Kirkby Nicholas S, Sampaio Walkyria, Etelvino Gisele, Alves Daniele T, Anders Katie L, Temponi Rafael, Shala Fisnik, Nair Anitha S, Ahmetaj-Shala Blerina, Jiao Jing, Herschman Harvey R, Xiaomeng Wang, Wahli Walter, Santos Robson A, Mitchell Jane A Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel PPARβ/δ-Dependent Vasodilator Pathway. Hypertension (Dallas, Tex. : 1979). 2018; 71(2): 297-305.
Le Thuc M, Poddar Soumya, Capri Joseph R, Abt Evan R, Kim Woosuk, Wei Liu, Uong Nhu T, Cheng Chloe M, Braas Daniel, Nikanjam Mina, Rix Peter, Merkurjev Daria, Zaretsky Jesse, Kornblum Harley I, Ribas Antoni, Herschman Harvey R, Whitelegge Julian, Faull Kym F, Donahue Timothy R, Czernin Johannes, Radu Caius G ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. Nature communications. 2017; 8(1): 241.
Lebedev Artem, Jiao Jing, Lee Jason, Yang Fan, Allison Nathanael, Herschman Harvey, Sadeghi Saman Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor. PloS one. 2017; 12(5): e0176606.
Lin Meng-Chieh, Chen Shih-Yin, Tsai Ho-Min, He Pei-Lin, Lin Yen-Chun, Herschman Harvey, Li Hua-Jung PGE. Stem cells (Dayton, Ohio). 2017; 35(2): 425-444.
Escuin-Ordinas Helena, Li Shuoran, Xie Michael W, Sun Lu, Hugo Willy, Huang Rong Rong, Jiao Jing, de-Faria Felipe Meira, Realegeno Susan, Krystofinski Paige, Azhdam Ariel, Komenan Sara Marie D, Atefi Mohammad, Comin-Anduix Begoña, Pellegrini Matteo, Cochran Alistair J, Modlin Robert L, Herschman Harvey R, Lo Roger S, McBride William H, Segura Tatiana, Ribas Antoni Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors. Nature communications. 2016; 7: 12348.
Kim Woosuk, Le Thuc M, Wei Liu, Poddar Soumya, Bazzy Jimmy, Wang Xuemeng, Uong Nhu T, Abt Evan R, Capri Joseph R, Austin Wayne R, Van Valkenburgh Juno S, Steele Dalton, Gipson Raymond M, Slavik Roger, Cabebe Anthony E, Taechariyakul Thotsophon, Yaghoubi Shahriar S, Lee Jason T, Sadeghi Saman, Lavie Arnon, Faull Kym F, Witte Owen N, Donahue Timothy R, Phelps Michael E, Herschman Harvey R, Herrmann Ken, Czernin Johannes, Radu Caius G [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(15): 4027-32.
Kirkby Nicholas S, Chan Melissa V, Zaiss Anne K, Garcia-Vaz Eliana, Jiao Jing, Berglund Lisa M, Verdu Elena F, Ahmetaj-Shala Blerina, Wallace John L, Herschman Harvey R, Gomez Maria F, Mitchell Jane A Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(2): 434-9.
Zaiss Anne K, Foley Erin M, Lawrence Roger, Schneider Lina S, Hoveida Hamidreza, Secrest Patrick, Catapang Arthur B, Yamaguchi Yu, Alemany Ramon, Shayakhmetov Dmitry M, Esko Jeffrey D, Herschman Harvey R Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo. Journal of virology. 2016; 90(1): 412-20.
Martinez Leonel, Ermolova Natalia V, Ishikawa Tomo-O, Stout David B, Herschman Harvey R, Spencer Melissa J A reporter mouse for optical imaging of inflammation in mdx muscles. Skeletal muscle. 2015; 5: 15.
Cherukuri Durga Prasad, Deignan Joshua L, Das Kingshuk, Grody Wayne W, Herschman Harvey Instability of a dinucleotide repeat in the 3'-untranslated region (UTR) of the microsomal prostaglandin E synthase-1 (mPGES-1) gene in microsatellite instability-high (MSI-H) colorectal carcinoma. Molecular oncology. 2015; 9(7): 1252-8.
Vadivel Kanagasabai, Ponnuraj Sathya-Moorthy, Kumar Yogesh, Zaiss Anne K, Bunce Matthew W, Camire Rodney M, Wu Ling, Evseenko Denis, Herschman Harvey R, Bajaj Madhu S, Bajaj S Paul Platelets contain tissue factor pathway inhibitor-2 derived from megakaryocytes and inhibits fibrinolysis. The Journal of biological chemistry. 2014; 289(45): 31647-61.
Jiao Jing, Ishikawa Tomo-O, Dumlao Darren S, Norris Paul C, Magyar Clara E, Mikulec Carol, Catapang Art, Dennis Edward A, Fischer Susan M, Herschman Harvey R Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer. Molecular cancer research : MCR. 2014; 12(11): 1677-88.
Roulis Manolis, Nikolaou Christoforos, Kotsaki Elena, Kaffe Eleanna, Karagianni Niki, Koliaraki Vasiliki, Salpea Klelia, Ragoussis Jiannis, Aidinis Vassilis, Martini Eva, Becker Christoph, Herschman Harvey R, Vetrano Stefania, Danese Silvio, Kollias George Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(43): E4658-67.
Zadran Sohila, Arumugam Rameshkumar, Herschman Harvey, Phelps Michael E, Levine R D Surprisal analysis characterizes the free energy time course of cancer cells undergoing epithelial-to-mesenchymal transition. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(36): 13235-40.
Wilhelms Daniel Björk, Kirilov Milen, Mirrasekhian Elahe, Eskilsson Anna, Kugelberg Unn Örtegren, Klar Christine, Ridder Dirk A, Herschman Harvey R, Schwaninger Markus, Blomqvist Anders, Engblom David Deletion of prostaglandin E2 synthesizing enzymes in brain endothelial cells attenuates inflammatory fever. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014; 34(35): 11684-90.
Zaiss Anne K, Zuber Johannes, Chu Chun, Machado Hidevaldo B, Jiao Jing, Catapang Arthur B, Ishikawa Tomo-o, Gil Jose S, Lowe Scott W, Herschman Harvey R Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo by inducible RNA interference. PloS one. 2014; 9(7): e101263.
Huang Chunlan, Xue Ming, Chen Hongli, Jiao Jing, Herschman Harvey R, O'Keefe Regis J, Zhang Xinping The spatiotemporal role of COX-2 in osteogenic and chondrogenic differentiation of periosteum-derived mesenchymal progenitors in fracture repair. PloS one. 2014; 9(7): e100079.
Mongini Patricia K A, Kramer Jill M, Ishikawa Tomo-O, Herschman Harvey, Esposito Donna Candidate chromosome 1 disease susceptibility genes for Sjogren's syndrome xerostomia are narrowed by novel NOD.B10 congenic mice. Clinical immunology (Orlando, Fla.). 2014; 153(1): 79-90.
Jiao Jing, Mikulec Carol, Ishikawa Tomo-o, Magyar Clara, Dumlao Darren S, Dennis Edward A, Fischer Susan M, Herschman Harvey Cell-type-specific roles for COX-2 in UVB-induced skin cancer. Carcinogenesis. 2014; 35(6): 1310-9.
An Ying, Belevych Natalya, Wang Yufen, Zhang Hao, Nasse Jason S, Herschman Harvey, Chen Qun, Tarr Andrew, Liu Xiaoyu, Quan Ning Prostacyclin mediates endothelial COX-2-dependent neuroprotective effects during excitotoxic brain injury. Journal of inflammation research. 2014; 7: 57-67.
Duarte Sergio, Kato Hiroyuki, Kuriyama Naohisa, Suko Kathryn, Ishikawa Tomo-O, Busuttil Ronald W, Herschman Harvey R, Coito Ana J Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice. PloS one. 2014; 9(5): e96913.
An Ying, Belevych Natalya, Wang Yufen, Zhang Hao, Herschman Harvey, Chen Qun, Quan Ning Neuronal and nonneuronal COX-2 expression confers neurotoxic and neuroprotective phenotypes in response to excitotoxin challenge. Journal of neuroscience research. 2014; 92(4): 486-95.
Nathanson David A, Armijo Amanda L, Tom Michelle, Li Zheng, Dimitrova Elizabeth, Austin Wayne R, Nomme Julian, Campbell Dean O, Ta Lisa, Le Thuc M, Lee Jason T, Darvish Ryan, Gordin Ari, Wei Liu, Liao Hsiang-I, Wilks Moses, Martin Colette, Sadeghi Saman, Murphy Jennifer M, Boulos Nidal, Phelps Michael E, Faull Kym F, Herschman Harvey R, Jung Michael E, Czernin Johannes, Lavie Arnon, Radu Caius G Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. The Journal of experimental medicine. 2014; 211(3): 473-86.
Escuin-Ordinas Helena, Atefi Mohammad, Fu Yong, Cass Ashley, Ng Charles, Huang Rong Rong, Yashar Sharona, Comin-Anduix Begonya, Avramis Earl, Cochran Alistair J, Marais Richard, Lo Roger S, Graeber Thomas G, Herschman Harvey R, Ribas Antoni COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors. Molecular oncology. 2014; 8(2): 250-60.
Cherukuri Durga P, Ishikawa Tomo-O, Chun Patrick, Catapang Art, Elashoff David, Grogan Tristan R, Bugni James, Herschman Harvey R Targeted Cox2 gene deletion in intestinal epithelial cells decreases tumorigenesis in female, but not male, ApcMin/+ mice. Molecular oncology. 2014; 8(2): 169-77.
Murphy Jennifer M, Armijo Amanda L, Nomme Julian, Lee Chi Hang, Smith Quentin A, Li Zheng, Campbell Dean O, Liao Hsiang-I, Nathanson David A, Austin Wayne R, Lee Jason T, Darvish Ryan, Wei Liu, Wang Jue, Su Ying, Damoiseaux Robert, Sadeghi Saman, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Alexandrova Anastassia N, Jung Michael E, Lavie Arnon, Radu Caius G Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. Journal of medicinal chemistry. 2013; 56(17): 6696-708.
Kirkby Nicholas S, Zaiss Anne K, Wright William R, Jiao Jing, Chan Melissa V, Warner Timothy D, Herschman Harvey R, Mitchell Jane A Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies. Biochemical and biophysical research communications. 2013; 438(2): 249-56.
Kirkby Nicholas S, Zaiss Anne K, Urquhart Paula, Jiao Jing, Austin Philip J, Al-Yamani Malak, Lundberg Martina H, MacKenzie Louise S, Warner Timothy D, Nicolaou Anna, Herschman Harvey R, Mitchell Jane A LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression. PloS one. 2013; 8(7): e69524.
Gil Jose S, Machado Hidevaldo B, Campbell Dean O, McCracken Melissa, Radu Caius, Witte Owen N, Herschman Harvey R Application of a Rapid, Simple, and Accurate Adenovirus-Based Method to Compare PET Reporter Gene/PET Reporter Probe Systems. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2013; 15(3): 273-81.
Austin Wayne R, Armijo Amanda L, Campbell Dean O, Singh Arun S, Hsieh Terry, Nathanson David, Herschman Harvey R, Phelps Michael E, Witte Owen N, Czernin Johannes, Radu Caius G Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress. The Journal of experimental medicine. 2012; 209(12): 2215-28.
Hill Reginald, Li Yunfeng, Tran Linh M, Dry Sarah, Calvopina Joseph Hargan, Garcia Alejandro, Kim Christine, Wang Ying, Donahue Timothy R, Herschman Harvey R, Wu Hong Cell intrinsic role of COX-2 in pancreatic cancer development. Molecular cancer therapeutics. 2012; 11(10): 2127-37.
Li Hua-Jung, Reinhardt Ferenc, Herschman Harvey R, Weinberg Robert A Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer discovery. 2012; 2(9): 840-55.
Herschman Harvey R, Czernin Johannes A spotlight from prostate cancer. Cancer discovery. 2012; 2(4): 301-3.
Campbell Dean O, Yaghoubi Shahriar S, Su Ying, Lee Jason T, Auerbach Martin S, Herschman Harvey, Satyamurthy Nagichettiar, Czernin Johannes, Lavie Arnon, Radu Caius G Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe. The Journal of biological chemistry. 2012; 287(1): 446-54.
Gil Jose S, Machado Hidevaldo B, Herschman Harvey R A Method to Rapidly and Accurately Compare the Relative Efficacies of Non-invasive Imaging Reporter Genes in a Mouse Model and its Application to Luciferase Reporters. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2011; .
Zaiss Anne K, Lawrence Roger, Elashoff David, Esko Jeffrey D, Herschman Harvey R Differential effects of murine and human factor X on adenovirus transduction via cell-surface heparan sulfate. The Journal of biological chemistry. 2011; 286(28): 24535-43.
Ishikawa Tomo-O, Oshima Masanobu, Herschman Harvey R Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis. Carcinogenesis. 2011; 32(3): 417-26.
Lu Yujie, Machado Hidevaldo B, Bao Qinan, Stout David, Herschman Harvey, Chatziioannou Arion F In vivo mouse bioluminescence tomography with radionuclide-based imaging validation. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2011; 13(1): 53-8.
Zhang Weizhou, Kater Arnon P, Widhopf George F, Chuang Han-Yu, Enzler Thomas, James Danelle F, Poustovoitov Maxim, Tseng Ping-Hui, Janz Siegfried, Hoh Carl, Herschman Harvey, Karin Michael, Kipps Thomas J B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(44): 18956-60.
Ishikawa Tomo-o, Jain Naveen K, Herschman Harvey R Cox-2 gene expression in chemically induced skin papillomas cannot predict subsequent tumor fate. Molecular oncology. 2010; 4(4): 347-56.
Tseng Han-Ching, Arasteh Aida, Paranjpe Avina, Teruel Antonia, Yang Wendy, Behel Armin, Alva Jackelyn A, Walter Gina, Head Christian, Ishikawa Tomo-o, Herschman Harvey R, Cacalano Nicholas, Pyle April D, Park No-Hee, Jewett Anahid Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells. PloS one. 2010; 5(7): e11590.
Papanicolaou Kyriakos N, Streicher John M, Ishikawa Tomo-O, Herschman Harvey, Wang Yibin, Walsh Kenneth Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2. Journal of molecular and cellular cardiology. 2010; 49(2): 196-209.
Streicher John M, Kamei Kenichiro, Ishikawa Tomo-o, Herschman Harvey, Wang Yibin Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice. Journal of molecular and cellular cardiology. 2010; 49(1): 88-94.
Watanabe Junji, Lin James A, Narasimha Ajay J, Shahbazian Ani, Ishikawa Tomo-O, Martin Martin G, Herschman Harvey R, Reddy Srinivasa T Novel anti-inflammatory functions for endothelial and myeloid cyclooxygenase-2 in a new mouse model of Crohn's disease. American journal of physiology. Gastrointestinal and liver physiology. 2010; 298(6): G842-50.
Ishikawa Tomo-O, Herschman Harvey R Conditional Bicistronic Cre Reporter Line Expressing Both Firefly Luciferase and beta-galactosidase. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2010; 298(6): .
Streicher John M, Ren Shuxun, Herschman Harvey, Wang Yibin MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart. Circulation research. 2010; 106(8): 1434-43.
Huang Hechang, Chikazu Daichi, Voznesensky Olga S, Herschman Harvey R, Kream Barbara E, Drissi Hicham, Pilbeam Carol C Parathyroid hormone induction of cyclooxygenase-2 in murine osteoblasts: role of the calcium-calcineurin-NFAT pathway. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2010; 25(4): 819-29.
Ishikawa Tomo-O, Kumar Indracanti Prem, Machado Hidevaldo B, Wong Koon-Pong, Kusewitt Donna, Huang Sung-Cheng, Fischer Susan M, Herschman Harvey R Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis. Molecular oncology. 2010; 4(2): 119-25.
Ishikawa Tomo-O, Herschman Harvey R Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression. Carcinogenesis. 2010; 31(4): 729-36.
Toy Gerald, Austin Wayne R, Liao Hsiang-I, Cheng Donghui, Singh Arun, Campbell Dean O, Ishikawa Tomo-o, Lehmann Lynn W, Satyamurthy Nagichettiar, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Witte Owen N, Radu Caius G Requirement for deoxycytidine kinase in T and B lymphocyte development. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(12): 5551-6.
Narasimha Ajay J, Watanabe Junji, Ishikawa Tomo-o, Priceman Saul J, Wu Lily, Herschman Harvey R, Reddy Srinivasa T Absence of myeloid COX-2 attenuates acute inflammation but does not influence development of atherosclerosis in apolipoprotein E null mice. Arteriosclerosis, thrombosis, and vascular biology. 2010; 30(2): 260-8.
Johnson Stuart L, Franz Christoph, Kuhn Stephanie, Furness David N, Rüttiger Lukas, Münkner Stefan, Rivolta Marcelo N, Seward Elizabeth P, Herschman Harvey R, Engel Jutta, Knipper Marlies, Marcotti Walter Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses. Nature neuroscience. 2010; 13(1): 45-52.
Lomenick Brett, Hao Rui, Jonai Nao, Chin Randall M, Aghajan Mariam, Warburton Sarah, Wang Jianing, Wu Raymond P, Gomez Fernando, Loo Joseph A, Wohlschlegel James A, Vondriska Thomas M, Pelletier Jerry, Herschman Harvey R, Clardy Jon, Clarke Catherine F, Huang Jing Target identification using drug affinity responsive target stability (DARTS). Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(51): 21984-9.
Lu Yujie, Douraghy Ali, Machado Hidevaldo B, Stout David, Tian Jie, Herschman Harvey, Chatziioannou Arion F Spectrally resolved bioluminescence tomography with the third-order simplified spherical harmonics approximation. Physics in medicine and biology. 2009; 54(21): 6477-93.
Zaiss Anne K, Machado Hidevaldo B, Herschman Harvey R The influence of innate and pre-existing immunity on adenovirus therapy. Journal of cellular biochemistry. 2009; 108(4): 778-90.
Lu Yujie, Machado Hidevaldo B, Douraghy Ali, Stout David, Herschman Harvey, Chatziioannou Arion F Experimental bioluminescence tomography with fully parallel radiative-transfer-based reconstruction framework. Optics express. 2009; 17(19): 16681-95.
Ohashi Koji, Ouchi Noriyuki, Sato Kaori, Higuchi Akiko, Ishikawa Tomo-o, Herschman Harvey R, Kihara Shinji, Walsh Kenneth Adiponectin promotes revascularization of ischemic muscle through a cyclooxygenase 2-dependent mechanism. Molecular and cellular biology. 2009; 29(13): 3487-99.
Laing Rachel E, Walter Martin A, Campbell Dean O, Herschman Harvey R, Satyamurthy Nagichettiar, Phelps Michael E, Czernin Johannes, Witte Owen N, Radu Caius G Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(8): 2847-52.
Li Hua-Jung, Everts Maaike, Yamamoto Masato, Curiel David T, Herschman Harvey R Combined transductional untargeting/retargeting and transcriptional restriction enhances adenovirus gene targeting and therapy for hepatic colorectal cancer tumors. Cancer research. 2009; 69(2): 554-64.
Ishikawa Tomo-O, Jain Naveen, Herschman Harvey R Feedback regulation of cyclooxygenase-2 transcription ex vivo and in vivo. Biochemical and biophysical research communications. 2009; 378(3): 534-8.
Kenanova Vania, Barat Bhaswati, Olafsen Tove, Chatziioannou Arion, Herschman Harvey R, Braun Jonathan, Wu Anna M Recombinant carcinoembryonic antigen as a reporter gene for molecular imaging. European journal of nuclear medicine and molecular imaging. 2009; 36(1): 104-14.
Jain Naveen K, Ishikawa Tomo-o, Spigelman Igor, Herschman Harvey R COX-2 expression and function in the hyperalgesic response to paw inflammation in mice. Prostaglandins, leukotrienes, and essential fatty acids. 2008; 79(6): 183-90.
Machado Hidevaldo B, Vician Linda J, Herschman Harvey R The MAPK pathway is required for depolarization-induced . Journal of neuroscience research. 2008; 86(3): 593-602.
Weber Wolfgang A, Czernin Johannes, Phelps Michael E, Herschman Harvey R Technology Insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs. Nature clinical practice. Oncology. 2008; 5(1): 44-54.
Ishikawa Tomo-o, Herschman Harvey R Two inducible, functional cyclooxygenase-2 genes are present in the rainbow trout genome. Journal of cellular biochemistry. 2007; 102(6): 1486-92.
Su Feng, Kozak Katherine R, Herschman Harvey, Reddy Srinivasa T, Farias-Eisner Robin Characterization of the rat urokinase plasminogen activator receptor promoter in PC12 cells. Journal of neuroscience research. 2007; 85(9): 1952-8.
Sui Guodong, Lee Cheng-Chung, Kamei Ken-Ichiro, Li Hua-Jung, Wang Jin-Yi, Wang Jun, Herschman Harvey R, Tseng Hsian-Rong A microfluidic platform for sequential ligand labeling and cell binding analysis. Biomedical microdevices. 2007; 9(3): 301-5.
Li Hua-Jung, Everts Maaike, Pereboeva Larisa, Komarova Svetlana, Idan Anat, Curiel David T, Herschman Harvey R Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapter. Cancer research. 2007; 67(11): 5354-61.
Koya Richard C, Kimura Takahiro, Ribas Antoni, Rozengurt Nora, Lawson Gregory W, Faure-Kumar Emmanuelle, Wang He-jing, Herschman Harvey, Kasahara Noriyuki, Stripecke Renata Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines. Molecular therapy : the journal of the American Society of Gene Therapy. 2007; 15(5): 971-80.
Ishikawa Tomo-O, Griffin Kevin J P, Banerjee Utpal, Herschman Harvey R The zebrafish genome contains two inducible, functional cyclooxygenase-2 genes. Biochemical and biophysical research communications. 2007; 352(1): 181-7.
Su Helen, Bodenstein Claudia, Dumont Rebecca A, Seimbille Yann, Dubinett Steven, Phelps Michael E, Herschman Harvey, Czernin Johannes, Weber Wolfgang Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006; 12(19): 5659-67.
Ishikawa Tomo-O, Jain Naveen K, Taketo Makoto M, Herschman Harvey R Imaging cyclooxygenase-2 (Cox-2) gene expression in living animals with a luciferase knock-in reporter gene. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2006; 8(3): 171-87.
Xu Zheng, Choudhary Shilpa, Voznesensky Olga, Mehrotra Meenal, Woodard Monica, Hansen Marc, Herschman Harvey, Pilbeam Carol Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis. Cancer research. 2006; 66(13): 6657-64.
Kamei Ken-ichiro, Ishikawa Tomo-o, Herschman Harvey R Transgenic mouse for conditional, tissue-specific Cox-2 overexpression. Genesis (New York, N.Y. : 2000). 2006; 44(4): 177-82.
Ishikawa Tomo-O, Herschman Harvey R Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 (Cox-2) gene. Genesis (New York, N.Y. : 2000). 2006; 44(3): 143-9.
Czernin Johannes, Weber Wolfgang A, Herschman Harvey R Molecular imaging in the development of cancer therapeutics. Annual review of medicine. 2006; 57(3): 99-118.
Lu Gang, Kang Young Jun, Han Jiahuai, Herschman Harvey R, Stefani Enrico, Wang Yibin TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling. The Journal of biological chemistry. 2006; 281(9): 6087-95.
Toyokuni Tatsushi, Kumar J S Dileep, Walsh Joseph C, Shapiro Alan, Talley John J, Phelps Michael E, Herschman Harvey R, Barrio Jorge R, Satyamurthy Nagichettiar Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography. Bioorganic & medicinal chemistry letters. 2005; 15(21): 4699-702.
Chikazu Daichi, Li Xiaodong, Kawaguchi Hiroshi, Sakuma Yoko, Voznesensky Olga S, Adams Douglas J, Xu Manshan, Hoshi Kazuto, Katavic Vedran, Herschman Harvey R, Raisz Lawrence G, Pilbeam Carol C Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfa1 binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. 2002. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2005; 20(10): 1888-98.
Yaghoubi Shahriar S, Barrio Jorge R, Namavari Mohammad, Satyamurthy Nagichettiar, Phelps Michael E, Herschman Harvey R, Gambhir Sanjiv S Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography. Cancer gene therapy. 2005; 12(3): 329-39.
Vician Linda J, Xu Guoping, Liu Wei, Feldman Jonathan D, Machado Hidevaldo B, Herschman Harvey R MAPKAP kinase-2 is a primary response gene induced by depolarization in PC12 cells and in brain. Journal of neuroscience research. 2004; 78(3): 315-28.
Liang Qianwa, Yamamoto Masato, Curiel David T, Herschman Harvey R Noninvasive imaging of transcriptionally restricted transgene expression following intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter gene. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2004; 6(6): 395-404.
Liang Qianwa, Dmitriev Igor, Kashentseva Elena, Curiel David T, Herschman Harvey R Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus receptor-epidermal growth factor (sCAR-EGF) fusion protein. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2004; 6(6): 385-94.
Singh Vinita, Miranda Tina Branscombe, Jiang Wei, Frankel Adam, Roemer Martha E, Robb Victoria A, Gutmann David H, Herschman Harvey R, Clarke Steven, Newsham Irene F DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. Oncogene. 2004; 23(47): 7761-71.
Herschman Harvey R PET reporter genes for noninvasive imaging of gene therapy, cell tracking and transgenic analysis. Critical reviews in oncology/hematology. 2004; 51(3): 191-204.
Ferguson Gregory D, Herschman Harvey R, Storm Daniel R Reduced anxiety and depression-like behavior in synaptotagmin IV (-/-) mice. Neuropharmacology. 2004; 47(4): 604-11.
Machado Hidevaldo B, Liu Wei, Vician Linda J, Herschman Harvey R Synaptotagmin IV overexpression inhibits depolarization-induced exocytosis in PC12 cells. Journal of neuroscience research. 2004; 76(3): 334-41.
Ferguson Gregory D, Wang Hongbing, Herschman Harvey R, Storm Daniel R Altered hippocampal short-term plasticity and associative memory in synaptotagmin IV (-/-) mice. Hippocampus. 2004; 14(8): 964-74.
Chen Ian Y, Wu Joseph C, Min Jung-Jun, Sundaresan Gobalakrishnan, Lewis Xiaoman, Liang Qianwa, Herschman Harvey R, Gambhir Sanjiv S Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery. Circulation. 2004; 109(11): 1415-20.
Herschman Harvey R Molecular imaging: a view from the inside. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 2004; 11(2): 210-4.
Herschman Harvey R Noninvasive imaging of reporter gene expression in living subjects. Advances in cancer research. 2004; 92(2): 29-80.
Smith Jeffrey B, Herschman Harvey R Targeted identification of glucocorticoid-attenuated response genes: in vitro and in vivo models. Proceedings of the American Thoracic Society. 2004; 1(3): 275-81.
Symensma Tonia L, Martinez-Guzman DeeAnn, Jia Qingmei, Bortz Eric, Wu Ting-Ting, Rudra-Ganguly Nandini, Cole Steve, Herschman Harvey, Sun Ren COX-2 induction during murine gammaherpesvirus 68 infection leads to enhancement of viral gene expression. Journal of virology. 2003; 77(23): 12753-63.
Herschman Harvey R, Talley John J, DuBois Raymond Cyclooxygenase 2 (COX-2) as a target for therapy and noninvasive imaging. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2003; 5(5): 286-303.
Herschman Harvey R Molecular imaging: looking at problems, seeing solutions. Science (New York, N.Y.). 2003; 302(5645): 605-8.
Herschman Harvey R Micro-PET imaging and small animal models of disease. Current opinion in immunology. 2003; 15(4): 378-84.
Nguyen Julie T, Machado Hidevaldo, Herschman Harvey R Repetitive, noninvasive imaging of cyclooxygenase-2 gene expression in living mice. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2003; 5(4): 248-56.
Liu Wei, Feldman Jonathan D, Machado Hidevaldo B, Vician Linda J, Herschman Harvey R Expression of depolarization-induced immediate early gene proteins in PC12 cells. Journal of neuroscience research. 2003; 72(6): 670-8.
Smith Jeffrey B, Wadleigh David J, Xia Yu-Rong, Mar Rebecca A, Herschman Harvey R, Lusis Aldons J Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5. Immunogenetics. 2002; 54(8): 599-603.
Lin Henry J, Lakkides Karen M, Keku Temitope O, Reddy Srinivasa T, Louie Andrew D, Kau Irving H, Zhou Haiyan, Gim Jason S Y, Ma Hoang L, Matthies Carl F, Dai Aihua, Huang Hsiao-Fen, Materi Alicia M, Lin Jesse H, Frankl Harold D, Lee Eric R, Hardy Steven I, Herschman Harvey R, Henderson Brian E, Kolonel Laurence N, Le Marchand Loïc, Garavito R Michael, Sandler Robert S, Haile Robert W, Smith William L Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2002; 11(11): 1305-15.
Rudra-Ganguly Nandini, Reddy Srinivasa T, Korge Paavo, Herschman Harvey R Diesel exhaust particle extracts and associated polycyclic aromatic hydrocarbons inhibit Cox-2-dependent prostaglandin synthesis in murine macrophages and fibroblasts. The Journal of biological chemistry. 2002; 277(42): 39259-65.
Smith Jeffrey B, Nguyen Tam T, Hughes Heather J, Herschman Harvey R, Widney Daniel P, Bui Kim C, Rovai Leonor E Glucocorticoid-attenuated response genes induced in the lung during endotoxemia. American journal of physiology. Lung cellular and molecular physiology. 2002; 283(3): L636-47.
Chikazu Daichi, Li Xiaodong, Kawaguchi Hiroshi, Sakuma Yoko, Voznesensky Olga S, Adams Douglas J, Xu Manshan, Hoshio Kazuto, Katavic Vedran, Herschman Harvey R, Raisz Lawrence G, Pilbeam Carol C Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2002; 17(8): 1430-40.
Liang Qianwa, Gotts Jeff, Satyamurthy Nagichettiar, Barrio Jorge, Phelps Michael E, Gambhir Sanjiv S, Herschman Harvey R Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus. Molecular therapy : the journal of the American Society of Gene Therapy. 2002; 6(1): 73-82.
Giza Christopher C, Prins Mayumi L, Hovda David A, Herschman Harvey R, Feldman Jonathan D Genes preferentially induced by depolarization after concussive brain injury: effects of age and injury severity. Journal of neurotrauma. 2002; 19(4): 387-402.
Cimato Thomas R, Tang Jie, Xu Ye, Guarnaccia Corrado, Herschman Harvey R, Pongor Sandor, Aletta John M Nerve growth factor-mediated increases in protein methylation occur predominantly at type I arginine methylation sites and involve protein arginine methyltransferase 1. Journal of neuroscience research. 2002; 67(4): 435-42.
Herschman Harvey R Non-invasive imaging of reporter genes. Journal of cellular biochemistry. Supplement. 2002; 39(4): 36-44.
Green Leeta A, Yap Cecelia S, Nguyen Khoi, Barrio Jorge R, Namavari Mohammad, Satyamurthy Nagichettiar, Phelps Michael E, Sandgren Eric P, Herschman Harvey R, Gambhir Sanjiv S Indirect monitoring of endogenous gene expression by positron emission tomography (PET) imaging of reporter gene expression in transgenic mice. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2002; 4(1): 71-81.