
FACULTY RESEARCH
Faculty List
Harvey Roy Herschman, Ph.D.
Work Email Address:
hherschman@mednet.ucla.edu
Fax Number:
(310) 825-6267
Office Phone Number:
(310) 825-8735
Office Address:
28-133 CHS; Los Angeles, CA 90095-1735
Department / Division Affiliations
Director, Molecular Pharmacology GPB Home Area |
Distinguished Research Professor, Biological Chemistry |
Ralph and Marjorie Crump Distinguished Professor Emeritus, Molecular & Medical Pharmacology |
Vice Chair, Molecular & Medical Pharmacology |
Member, CTSI, Crump Institute for Molecular Imaging, I3T Theme, JCCC Cancer Molecular Imaging, Molecular Biology Institute |
Research Interests
We study how extracellular stimuli elicit changes in cell growth and differentiation, as a result of induced transcription of "primary response" genes. One gene we discovered encodes a second form of cyclooxygenase (COX-2), the rate limiting enzyme in prostaglandin production and the target of a new generation of anti-inflammatory, anti-pyretic and analgesic pharmaceutical agents. We also identified synaptotagmin 4 as a depolarization-induced neuronal gene; a candidate for a mediator of depolarization-induced synaptic plasticity. We have also merged principles of cell biology, molecular biology and molecular imaging technologies to develop procedures that repetitively, non-invasively and quantitatively image reporter gene expression in intact, living animals. More recently, we have demonstrated (1) that Hexokinase 2 and hexokinase 1 (HK2 and HK1) are redundant for glycolysis in most cancers, and that HK2 cannot serve as a target for cancer therapy in these tumors. However (2), in tumors that do not express HK1 and only express HK2, that HK2, in combination with other metabolic enzymes, is targetable for cancer therapy.
Publications
A selected list of publications:
Xu Shili, Catapang Arthur, Braas Daniel, Stiles Linsey, Doh Hanna M, Lee Jason T, Graeber Thomas G, Damoiseaux Robert, Shirihai Orian, Herschman Harvey R
A precision therapeutic strategy for hexokinase 1-null, hexokinase
2-positive cancers
Cancer & metabolism,
2018; 6:
7.
Xu, S., Catapang, A., Doh, H.M., Bayley, N.A., Lee, J.T., Braas, D., Graeber, T.G., Herschman, H.R.
Hexokinase-2 is targetable for HK1 negative, HK2 positive tumors from a wide variety of tissues of origin,
J. Nucl. Med,
2018; 59:
.
Lin Meng-Chieh, Chen Shih-Yin, He Pei-Lin, Herschman Harvey, Li Hua-Jung
PGE
International journal of cancer,
2018; 143(6):
1440-1455.
Kirkby Nicholas S, Sampaio Walkyria, Etelvino Gisele, Alves Daniele T, Anders Katie L, Temponi Rafael, Shala Fisnik, Nair Anitha S, Ahmetaj-Shala Blerina, Jiao Jing, Herschman Harvey R, Xiaomeng Wang, Wahli Walter, Santos Robson A, Mitchell Jane A
Cyclooxygenase-2 Selectively Controls Renal Blood Flow Through a Novel
PPARβ/δ-Dependent Vasodilator Pathway
Hypertension (Dallas, Tex. : 1979),
2018; 71(2):
297-305.
Le Thuc M, Poddar Soumya, Capri Joseph R, Abt Evan R, Kim Woosuk, Wei Liu, Uong Nhu T, Cheng Chloe M, Braas Daniel, Nikanjam Mina, Rix Peter, Merkurjev Daria, Zaretsky Jesse, Kornblum Harley I, Ribas Antoni, Herschman Harvey R, Whitelegge Julian, Faull Kym F, Donahue Timothy R, Czernin Johannes, Radu Caius G
ATR inhibition facilitates targeting of leukemia dependence on
convergent nucleotide biosynthetic pathways
Nature communications,
2017; 8(1):
241.
Lebedev Artem, Jiao Jing, Lee Jason, Yang Fan, Allison Nathanael, Herschman Harvey, Sadeghi Saman
Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo
stable COX-2 inhibitor
PloS one,
2017; 12(5):
e0176606.
Lin Meng-Chieh, Chen Shih-Yin, Tsai Ho-Min, He Pei-Lin, Lin Yen-Chun, Herschman Harvey, Li Hua-Jung
PGE
Stem cells (Dayton, Ohio),
2017; 35(2):
425-444.
Escuin-Ordinas Helena, Li Shuoran, Xie Michael W, Sun Lu, Hugo Willy, Huang Rong Rong, Jiao Jing, de-Faria Felipe Meira, Realegeno Susan, Krystofinski Paige, Azhdam Ariel, Komenan Sara Marie D, Atefi Mohammad, Comin-Anduix Begoña, Pellegrini Matteo, Cochran Alistair J, Modlin Robert L, Herschman Harvey R, Lo Roger S, McBride William H, Segura Tatiana, Ribas Antoni
Cutaneous wound healing through paradoxical MAPK activation by BRAF
inhibitors
Nature communications,
2016; 7:
12348.
Kim Woosuk, Le Thuc M, Wei Liu, Poddar Soumya, Bazzy Jimmy, Wang Xuemeng, Uong Nhu T, Abt Evan R, Capri Joseph R, Austin Wayne R, Van Valkenburgh Juno S, Steele Dalton, Gipson Raymond M, Slavik Roger, Cabebe Anthony E, Taechariyakul Thotsophon, Yaghoubi Shahriar S, Lee Jason T, Sadeghi Saman, Lavie Arnon, Faull Kym F, Witte Owen N, Donahue Timothy R, Phelps Michael E, Herschman Harvey R, Herrmann Ken, Czernin Johannes, Radu Caius G
[18F]CFA as a clinically translatable probe for PET imaging of
deoxycytidine kinase activity
Proceedings of the National Academy of Sciences of the United States of America,
2016; 113(15):
4027-32.
Kirkby Nicholas S, Chan Melissa V, Zaiss Anne K, Garcia-Vaz Eliana, Jiao Jing, Berglund Lisa M, Verdu Elena F, Ahmetaj-Shala Blerina, Wallace John L, Herschman Harvey R, Gomez Maria F, Mitchell Jane A
Systematic study of constitutive cyclooxygenase-2 expression: Role of
NF-κB and NFAT transcriptional pathways
Proceedings of the National Academy of Sciences of the United States of America,
2016; 113(2):
434-9.
Zaiss Anne K, Foley Erin M, Lawrence Roger, Schneider Lina S, Hoveida Hamidreza, Secrest Patrick, Catapang Arthur B, Yamaguchi Yu, Alemany Ramon, Shayakhmetov Dmitry M, Esko Jeffrey D, Herschman Harvey R
Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2
but Dispensable for Adenovirus 5 Liver Transduction In Vivo
Journal of virology,
2016; 90(1):
412-20.
Martinez Leonel, Ermolova Natalia V, Ishikawa Tomo-O, Stout David B, Herschman Harvey R, Spencer Melissa J
A reporter mouse for optical imaging of inflammation in mdx muscles
Skeletal muscle,
2015; 5:
15.
Cherukuri Durga Prasad, Deignan Joshua L, Das Kingshuk, Grody Wayne W, Herschman Harvey
Instability of a dinucleotide repeat in the 3'-untranslated region
(UTR) of the microsomal prostaglandin E synthase-1 (mPGES-1) gene in
microsatellite instability-high (MSI-H) colorectal carcinoma
Molecular oncology,
2015; 9(7):
1252-8.
Vadivel Kanagasabai, Ponnuraj Sathya-Moorthy, Kumar Yogesh, Zaiss Anne K, Bunce Matthew W, Camire Rodney M, Wu Ling, Evseenko Denis, Herschman Harvey R, Bajaj Madhu S, Bajaj S Paul
Platelets contain tissue factor pathway inhibitor-2 derived from
megakaryocytes and inhibits fibrinolysis
The Journal of biological chemistry,
2014; 289(45):
31647-61.
Jiao Jing, Ishikawa Tomo-O, Dumlao Darren S, Norris Paul C, Magyar Clara E, Mikulec Carol, Catapang Art, Dennis Edward A, Fischer Susan M, Herschman Harvey R
Targeted deletion and lipidomic analysis identify epithelial cell
COX-2 as a major driver of chemically induced skin cancer
Molecular cancer research : MCR,
2014; 12(11):
1677-88.
Roulis Manolis, Nikolaou Christoforos, Kotsaki Elena, Kaffe Eleanna, Karagianni Niki, Koliaraki Vasiliki, Salpea Klelia, Ragoussis Jiannis, Aidinis Vassilis, Martini Eva, Becker Christoph, Herschman Harvey R, Vetrano Stefania, Danese Silvio, Kollias George
Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate
sensing to epithelial homeostasis
Proceedings of the National Academy of Sciences of the United States of America,
2014; 111(43):
E4658-67.
Zadran Sohila, Arumugam Rameshkumar, Herschman Harvey, Phelps Michael E, Levine R D
Surprisal analysis characterizes the free energy time course of cancer
cells undergoing epithelial-to-mesenchymal transition
Proceedings of the National Academy of Sciences of the United States of America,
2014; 111(36):
13235-40.
Wilhelms Daniel Björk, Kirilov Milen, Mirrasekhian Elahe, Eskilsson Anna, Kugelberg Unn Örtegren, Klar Christine, Ridder Dirk A, Herschman Harvey R, Schwaninger Markus, Blomqvist Anders, Engblom David
Deletion of prostaglandin E2 synthesizing enzymes in brain endothelial
cells attenuates inflammatory fever
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2014; 34(35):
11684-90.
Zaiss Anne K, Zuber Johannes, Chu Chun, Machado Hidevaldo B, Jiao Jing, Catapang Arthur B, Ishikawa Tomo-o, Gil Jose S, Lowe Scott W, Herschman Harvey R
Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo
by inducible RNA interference
PloS one,
2014; 9(7):
e101263.
Huang Chunlan, Xue Ming, Chen Hongli, Jiao Jing, Herschman Harvey R, O'Keefe Regis J, Zhang Xinping
The spatiotemporal role of COX-2 in osteogenic and chondrogenic
differentiation of periosteum-derived mesenchymal progenitors in
fracture repair
PloS one,
2014; 9(7):
e100079.
Mongini Patricia K A, Kramer Jill M, Ishikawa Tomo-O, Herschman Harvey, Esposito Donna
Candidate chromosome 1 disease susceptibility genes for Sjogren's
syndrome xerostomia are narrowed by novel NOD.B10 congenic mice
Clinical immunology (Orlando, Fla.),
2014; 153(1):
79-90.
Jiao Jing, Mikulec Carol, Ishikawa Tomo-o, Magyar Clara, Dumlao Darren S, Dennis Edward A, Fischer Susan M, Herschman Harvey
Cell-type-specific roles for COX-2 in UVB-induced skin cancer
Carcinogenesis,
2014; 35(6):
1310-9.
An Ying, Belevych Natalya, Wang Yufen, Zhang Hao, Nasse Jason S, Herschman Harvey, Chen Qun, Tarr Andrew, Liu Xiaoyu, Quan Ning
Prostacyclin mediates endothelial COX-2-dependent neuroprotective
effects during excitotoxic brain injury
Journal of inflammation research,
2014; 7:
57-67.
Duarte Sergio, Kato Hiroyuki, Kuriyama Naohisa, Suko Kathryn, Ishikawa Tomo-O, Busuttil Ronald W, Herschman Harvey R, Coito Ana J
Hepatic ischemia and reperfusion injury in the absence of myeloid
cell-derived COX-2 in mice
PloS one,
2014; 9(5):
e96913.
An Ying, Belevych Natalya, Wang Yufen, Zhang Hao, Herschman Harvey, Chen Qun, Quan Ning
Neuronal and nonneuronal COX-2 expression confers neurotoxic and
neuroprotective phenotypes in response to excitotoxin challenge
Journal of neuroscience research,
2014; 92(4):
486-95.
Nathanson David A, Armijo Amanda L, Tom Michelle, Li Zheng, Dimitrova Elizabeth, Austin Wayne R, Nomme Julian, Campbell Dean O, Ta Lisa, Le Thuc M, Lee Jason T, Darvish Ryan, Gordin Ari, Wei Liu, Liao Hsiang-I, Wilks Moses, Martin Colette, Sadeghi Saman, Murphy Jennifer M, Boulos Nidal, Phelps Michael E, Faull Kym F, Herschman Harvey R, Jung Michael E, Czernin Johannes, Lavie Arnon, Radu Caius G
Co-targeting of convergent nucleotide biosynthetic pathways for
leukemia eradication
The Journal of experimental medicine,
2014; 211(3):
473-86.
Escuin-Ordinas Helena, Atefi Mohammad, Fu Yong, Cass Ashley, Ng Charles, Huang Rong Rong, Yashar Sharona, Comin-Anduix Begonya, Avramis Earl, Cochran Alistair J, Marais Richard, Lo Roger S, Graeber Thomas G, Herschman Harvey R, Ribas Antoni
COX-2 inhibition prevents the appearance of cutaneous squamous cell
carcinomas accelerated by BRAF inhibitors
Molecular oncology,
2014; 8(2):
250-60.
Cherukuri Durga P, Ishikawa Tomo-O, Chun Patrick, Catapang Art, Elashoff David, Grogan Tristan R, Bugni James, Herschman Harvey R
Targeted Cox2 gene deletion in intestinal epithelial cells decreases
tumorigenesis in female, but not male, ApcMin/+ mice
Molecular oncology,
2014; 8(2):
169-77.
Murphy Jennifer M, Armijo Amanda L, Nomme Julian, Lee Chi Hang, Smith Quentin A, Li Zheng, Campbell Dean O, Liao Hsiang-I, Nathanson David A, Austin Wayne R, Lee Jason T, Darvish Ryan, Wei Liu, Wang Jue, Su Ying, Damoiseaux Robert, Sadeghi Saman, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Alexandrova Anastassia N, Jung Michael E, Lavie Arnon, Radu Caius G
Development of new deoxycytidine kinase inhibitors and noninvasive in
vivo evaluation using positron emission tomography
Journal of medicinal chemistry,
2013; 56(17):
6696-708.
Kirkby Nicholas S, Zaiss Anne K, Wright William R, Jiao Jing, Chan Melissa V, Warner Timothy D, Herschman Harvey R, Mitchell Jane A
Differential COX-2 induction by viral and bacterial PAMPs:
Consequences for cytokine and interferon responses and implications
for anti-viral COX-2 directed therapies
Biochemical and biophysical research communications,
2013; 438(2):
249-56.
Kirkby Nicholas S, Zaiss Anne K, Urquhart Paula, Jiao Jing, Austin Philip J, Al-Yamani Malak, Lundberg Martina H, MacKenzie Louise S, Warner Timothy D, Nicolaou Anna, Herschman Harvey R, Mitchell Jane A
LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene
expression pattern reveals non-vascular sites of COX-2 expression
PloS one,
2013; 8(7):
e69524.
Gil Jose S, Machado Hidevaldo B, Campbell Dean O, McCracken Melissa, Radu Caius, Witte Owen N, Herschman Harvey R
Application of a Rapid, Simple, and Accurate Adenovirus-Based Method
to Compare PET Reporter Gene/PET Reporter Probe Systems
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging,
2013; 15(3):
273-81.
Austin Wayne R, Armijo Amanda L, Campbell Dean O, Singh Arun S, Hsieh Terry, Nathanson David, Herschman Harvey R, Phelps Michael E, Witte Owen N, Czernin Johannes, Radu Caius G
Nucleoside salvage pathway kinases regulate hematopoiesis by linking
nucleotide metabolism with replication stress
The Journal of experimental medicine,
2012; 209(12):
2215-28.
Hill Reginald, Li Yunfeng, Tran Linh M, Dry Sarah, Calvopina Joseph Hargan, Garcia Alejandro, Kim Christine, Wang Ying, Donahue Timothy R, Herschman Harvey R, Wu Hong
Cell intrinsic role of COX-2 in pancreatic cancer development
Molecular cancer therapeutics,
2012; 11(10):
2127-37.
Li Hua-Jung, Reinhardt Ferenc, Herschman Harvey R, Weinberg Robert A
Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell
niche via prostaglandin E2 signaling
Cancer discovery,
2012; 2(9):
840-55.
Herschman Harvey R, Czernin Johannes
A spotlight from prostate cancer
Cancer discovery,
2012; 2(4):
301-3.
Campbell Dean O, Yaghoubi Shahriar S, Su Ying, Lee Jason T, Auerbach Martin S, Herschman Harvey, Satyamurthy Nagichettiar, Czernin Johannes, Lavie Arnon, Radu Caius G
Structure-guided engineering of human thymidine kinase 2 as a positron
emission tomography reporter gene for enhanced phosphorylation of
non-natural thymidine analog reporter probe
The Journal of biological chemistry,
2012; 287(1):
446-54.
Gil Jose S, Machado Hidevaldo B, Herschman Harvey R
A Method to Rapidly and Accurately Compare the Relative Efficacies of
Non-invasive Imaging Reporter Genes in a Mouse Model and its
Application to Luciferase Reporters
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging,
2011;
.
Zaiss Anne K, Lawrence Roger, Elashoff David, Esko Jeffrey D, Herschman Harvey R
Differential effects of murine and human factor X on adenovirus
transduction via cell-surface heparan sulfate
The Journal of biological chemistry,
2011; 286(28):
24535-43.
Ishikawa Tomo-O, Oshima Masanobu, Herschman Harvey R
Cox-2 deletion in myeloid and endothelial cells, but not in epithelial
cells, exacerbates murine colitis
Carcinogenesis,
2011; 32(3):
417-26.
Lu Yujie, Machado Hidevaldo B, Bao Qinan, Stout David, Herschman Harvey, Chatziioannou Arion F
In vivo mouse bioluminescence tomography with radionuclide-based
imaging validation
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging,
2011; 13(1):
53-8.
Zhang Weizhou, Kater Arnon P, Widhopf George F, Chuang Han-Yu, Enzler Thomas, James Danelle F, Poustovoitov Maxim, Tseng Ping-Hui, Janz Siegfried, Hoh Carl, Herschman Harvey, Karin Michael, Kipps Thomas J
B-cell activating factor and v-Myc myelocytomatosis viral oncogene
homolog (c-Myc) influence progression of chronic lymphocytic leukemia
Proceedings of the National Academy of Sciences of the United States of America,
2010; 107(44):
18956-60.
Ishikawa Tomo-o, Jain Naveen K, Herschman Harvey R
Cox-2 gene expression in chemically induced skin papillomas cannot
predict subsequent tumor fate
Molecular oncology,
2010; 4(4):
347-56.
Tseng Han-Ching, Arasteh Aida, Paranjpe Avina, Teruel Antonia, Yang Wendy, Behel Armin, Alva Jackelyn A, Walter Gina, Head Christian, Ishikawa Tomo-o, Herschman Harvey R, Cacalano Nicholas, Pyle April D, Park No-Hee, Jewett Anahid
Increased lysis of stem cells but not their differentiated cells by
natural killer cells; de-differentiation or reprogramming activates NK
cells
PloS one,
2010; 5(7):
e11590.
Papanicolaou Kyriakos N, Streicher John M, Ishikawa Tomo-O, Herschman Harvey, Wang Yibin, Walsh Kenneth
Preserved heart function and maintained response to cardiac stresses
in a genetic model of cardiomyocyte-targeted deficiency of
cyclooxygenase-2
Journal of molecular and cellular cardiology,
2010; 49(2):
196-209.
Streicher John M, Kamei Kenichiro, Ishikawa Tomo-o, Herschman Harvey, Wang Yibin
Compensatory hypertrophy induced by ventricular cardiomyocyte-specific
COX-2 expression in mice
Journal of molecular and cellular cardiology,
2010; 49(1):
88-94.
Watanabe Junji, Lin James A, Narasimha Ajay J, Shahbazian Ani, Ishikawa Tomo-O, Martin Martin G, Herschman Harvey R, Reddy Srinivasa T
Novel anti-inflammatory functions for endothelial and myeloid
cyclooxygenase-2 in a new mouse model of Crohn's disease
American journal of physiology. Gastrointestinal and liver physiology,
2010; 298(6):
G842-50.
Ishikawa Tomo-O, Herschman Harvey R
Conditional Bicistronic Cre Reporter Line Expressing Both Firefly
Luciferase and beta-galactosidase
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging,
2010; 298(6):
.
Streicher John M, Ren Shuxun, Herschman Harvey, Wang Yibin
MAPK-activated protein kinase-2 in cardiac hypertrophy and
cyclooxygenase-2 regulation in heart
Circulation research,
2010; 106(8):
1434-43.
Huang Hechang, Chikazu Daichi, Voznesensky Olga S, Herschman Harvey R, Kream Barbara E, Drissi Hicham, Pilbeam Carol C
Parathyroid hormone induction of cyclooxygenase-2 in murine
osteoblasts: role of the calcium-calcineurin-NFAT pathway
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
2010; 25(4):
819-29.
Ishikawa Tomo-O, Kumar Indracanti Prem, Machado Hidevaldo B, Wong Koon-Pong, Kusewitt Donna, Huang Sung-Cheng, Fischer Susan M, Herschman Harvey R
Positron emission tomography imaging of DMBA/TPA mouse skin multi-step
tumorigenesis
Molecular oncology,
2010; 4(2):
119-25.
Ishikawa Tomo-O, Herschman Harvey R
Tumor formation in a mouse model of colitis-associated colon cancer
does not require COX-1 or COX-2 expression
Carcinogenesis,
2010; 31(4):
729-36.
Toy Gerald, Austin Wayne R, Liao Hsiang-I, Cheng Donghui, Singh Arun, Campbell Dean O, Ishikawa Tomo-o, Lehmann Lynn W, Satyamurthy Nagichettiar, Phelps Michael E, Herschman Harvey R, Czernin Johannes, Witte Owen N, Radu Caius G
Requirement for deoxycytidine kinase in T and B lymphocyte
development
Proceedings of the National Academy of Sciences of the United States of America,
2010; 107(12):
5551-6.
Narasimha Ajay J, Watanabe Junji, Ishikawa Tomo-o, Priceman Saul J, Wu Lily, Herschman Harvey R, Reddy Srinivasa T
Absence of myeloid COX-2 attenuates acute inflammation but does not
influence development of atherosclerosis in apolipoprotein E null
mice
Arteriosclerosis, thrombosis, and vascular biology,
2010; 30(2):
260-8.
Johnson Stuart L, Franz Christoph, Kuhn Stephanie, Furness David N, Rüttiger Lukas, Münkner Stefan, Rivolta Marcelo N, Seward Elizabeth P, Herschman Harvey R, Engel Jutta, Knipper Marlies, Marcotti Walter
Synaptotagmin IV determines the linear Ca2+ dependence of vesicle
fusion at auditory ribbon synapses
Nature neuroscience,
2010; 13(1):
45-52.
Lomenick Brett, Hao Rui, Jonai Nao, Chin Randall M, Aghajan Mariam, Warburton Sarah, Wang Jianing, Wu Raymond P, Gomez Fernando, Loo Joseph A, Wohlschlegel James A, Vondriska Thomas M, Pelletier Jerry, Herschman Harvey R, Clardy Jon, Clarke Catherine F, Huang Jing
Target identification using drug affinity responsive target stability
(DARTS)
Proceedings of the National Academy of Sciences of the United States of America,
2009; 106(51):
21984-9.
Lu Yujie, Douraghy Ali, Machado Hidevaldo B, Stout David, Tian Jie, Herschman Harvey, Chatziioannou Arion F
Spectrally resolved bioluminescence tomography with the third-order
simplified spherical harmonics approximation
Physics in medicine and biology,
2009; 54(21):
6477-93.
Zaiss Anne K, Machado Hidevaldo B, Herschman Harvey R
The influence of innate and pre-existing immunity on adenovirus
therapy
Journal of cellular biochemistry,
2009; 108(4):
778-90.
Lu Yujie, Machado Hidevaldo B, Douraghy Ali, Stout David, Herschman Harvey, Chatziioannou Arion F
Experimental bioluminescence tomography with fully parallel
radiative-transfer-based reconstruction framework
Optics express,
2009; 17(19):
16681-95.
Ohashi Koji, Ouchi Noriyuki, Sato Kaori, Higuchi Akiko, Ishikawa Tomo-o, Herschman Harvey R, Kihara Shinji, Walsh Kenneth
Adiponectin promotes revascularization of ischemic muscle through a
cyclooxygenase 2-dependent mechanism
Molecular and cellular biology,
2009; 29(13):
3487-99.
Laing Rachel E, Walter Martin A, Campbell Dean O, Herschman Harvey R, Satyamurthy Nagichettiar, Phelps Michael E, Czernin Johannes, Witte Owen N, Radu Caius G
Noninvasive prediction of tumor responses to gemcitabine using
positron emission tomography
Proceedings of the National Academy of Sciences of the United States of America,
2009; 106(8):
2847-52.
Li Hua-Jung, Everts Maaike, Yamamoto Masato, Curiel David T, Herschman Harvey R
Combined transductional untargeting/retargeting and transcriptional
restriction enhances adenovirus gene targeting and therapy for hepatic
colorectal cancer tumors
Cancer research,
2009; 69(2):
554-64.
Ishikawa Tomo-O, Jain Naveen, Herschman Harvey R
Feedback regulation of cyclooxygenase-2 transcription ex vivo and in
vivo
Biochemical and biophysical research communications,
2009; 378(3):
534-8.
Kenanova Vania, Barat Bhaswati, Olafsen Tove, Chatziioannou Arion, Herschman Harvey R, Braun Jonathan, Wu Anna M
Recombinant carcinoembryonic antigen as a reporter gene for molecular
imaging
European journal of nuclear medicine and molecular imaging,
2009; 36(1):
104-14.
Jain Naveen K, Ishikawa Tomo-o, Spigelman Igor, Herschman Harvey R
COX-2 expression and function in the hyperalgesic response to paw
inflammation in mice
Prostaglandins, leukotrienes, and essential fatty acids,
2008; 79(6):
183-90.
Machado Hidevaldo B, Vician Linda J, Herschman Harvey R
The MAPK pathway is required for depolarization-induced
Journal of neuroscience research,
2008; 86(3):
593-602.
Weber Wolfgang A, Czernin Johannes, Phelps Michael E, Herschman Harvey R
Technology Insight: novel imaging of molecular targets is an emerging area crucial to the development of targeted drugs
Nature clinical practice. Oncology,
2008; 5(1):
44-54.
Ishikawa Tomo-o, Herschman Harvey R
Two inducible, functional cyclooxygenase-2 genes are present in the rainbow trout genome
Journal of cellular biochemistry,
2007; 102(6):
1486-92.
Su Feng, Kozak Katherine R, Herschman Harvey, Reddy Srinivasa T, Farias-Eisner Robin
Characterization of the rat urokinase plasminogen activator receptor
promoter in PC12 cells
Journal of neuroscience research,
2007; 85(9):
1952-8.
Sui Guodong, Lee Cheng-Chung, Kamei Ken-Ichiro, Li Hua-Jung, Wang Jin-Yi, Wang Jun, Herschman Harvey R, Tseng Hsian-Rong
A microfluidic platform for sequential ligand labeling and cell binding analysis
Biomedical microdevices,
2007; 9(3):
301-5.
Li Hua-Jung, Everts Maaike, Pereboeva Larisa, Komarova Svetlana, Idan Anat, Curiel David T, Herschman Harvey R
Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapter
Cancer research,
2007; 67(11):
5354-61.
Koya Richard C, Kimura Takahiro, Ribas Antoni, Rozengurt Nora, Lawson Gregory W, Faure-Kumar Emmanuelle, Wang He-jing, Herschman Harvey, Kasahara Noriyuki, Stripecke Renata
Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines
Molecular therapy : the journal of the American Society of Gene Therapy,
2007; 15(5):
971-80.
Ishikawa Tomo-O, Griffin Kevin J P, Banerjee Utpal, Herschman Harvey R
The zebrafish genome contains two inducible, functional cyclooxygenase-2 genes
Biochemical and biophysical research communications,
2007; 352(1):
181-7.
Su Helen, Bodenstein Claudia, Dumont Rebecca A, Seimbille Yann, Dubinett Steven, Phelps Michael E, Herschman Harvey, Czernin Johannes, Weber Wolfgang
Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitors
Clinical cancer research : an official journal of the American Association for Cancer Research,
2006; 12(19):
5659-67.
Ishikawa Tomo-O, Jain Naveen K, Taketo Makoto M, Herschman Harvey R
Imaging cyclooxygenase-2 (Cox-2) gene expression in living animals with a luciferase knock-in reporter gene
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging,
2006; 8(3):
171-87.
Xu Zheng, Choudhary Shilpa, Voznesensky Olga, Mehrotra Meenal, Woodard Monica, Hansen Marc, Herschman Harvey, Pilbeam Carol
Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis
Cancer research,
2006; 66(13):
6657-64.
Kamei Ken-ichiro, Ishikawa Tomo-o, Herschman Harvey R
Transgenic mouse for conditional, tissue-specific Cox-2 overexpression
Genesis (New York, N.Y. : 2000),
2006; 44(4):
177-82.
Ishikawa Tomo-O, Herschman Harvey R
Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 (Cox-2) gene
Genesis (New York, N.Y. : 2000),
2006; 44(3):
143-9.
Czernin Johannes, Weber Wolfgang A, Herschman Harvey R
Molecular imaging in the development of cancer therapeutics
Annual review of medicine,
2006; 57(3):
99-118.
Lu Gang, Kang Young Jun, Han Jiahuai, Herschman Harvey R, Stefani Enrico, Wang Yibin
TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling
The Journal of biological chemistry,
2006; 281(9):
6087-95.
Toyokuni Tatsushi, Kumar J S Dileep, Walsh Joseph C, Shapiro Alan, Talley John J, Phelps Michael E, Herschman Harvey R, Barrio Jorge R, Satyamurthy Nagichettiar
Synthesis of
4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new
[18F]fluorinated analogue of valdecoxib, as a potential radiotracer
for imaging cyclooxygenase-2 with positron emission tomography
Bioorganic & medicinal chemistry letters,
2005; 15(21):
4699-702.
Chikazu Daichi, Li Xiaodong, Kawaguchi Hiroshi, Sakuma Yoko, Voznesensky Olga S, Adams Douglas J, Xu Manshan, Hoshi Kazuto, Katavic Vedran, Herschman Harvey R, Raisz Lawrence G, Pilbeam Carol C
Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfa1 binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. 2002
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
2005; 20(10):
1888-98.
Yaghoubi Shahriar S, Barrio Jorge R, Namavari Mohammad, Satyamurthy Nagichettiar, Phelps Michael E, Herschman Harvey R, Gambhir Sanjiv S
Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography
Cancer gene therapy,
2005; 12(3):
329-39.
Vician Linda J, Xu Guoping, Liu Wei, Feldman Jonathan D, Machado Hidevaldo B, Herschman Harvey R
MAPKAP kinase-2 is a primary response gene induced by depolarization in PC12 cells and in brain
Journal of neuroscience research,
2004; 78(3):
315-28.
Liang Qianwa, Yamamoto Masato, Curiel David T, Herschman Harvey R
Noninvasive imaging of transcriptionally restricted transgene expression following intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter gene
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging,
2004; 6(6):
395-404.
Liang Qianwa, Dmitriev Igor, Kashentseva Elena, Curiel David T, Herschman Harvey R
Noninvasive of adenovirus tumor retargeting in living subjects by a soluble adenovirus receptor-epidermal growth factor (sCAR-EGF) fusion protein
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging,
2004; 6(6):
385-94.
Singh Vinita, Miranda Tina Branscombe, Jiang Wei, Frankel Adam, Roemer Martha E, Robb Victoria A, Gutmann David H, Herschman Harvey R, Clarke Steven, Newsham Irene F
DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo
Oncogene,
2004; 23(47):
7761-71.
Herschman Harvey R
PET reporter genes for noninvasive imaging of gene therapy, cell tracking and transgenic analysis
Critical reviews in oncology/hematology,
2004; 51(3):
191-204.
Ferguson Gregory D, Herschman Harvey R, Storm Daniel R
Reduced anxiety and depression-like behavior in synaptotagmin IV (-/-) mice
Neuropharmacology,
2004; 47(4):
604-11.
Machado Hidevaldo B, Liu Wei, Vician Linda J, Herschman Harvey R
Synaptotagmin IV overexpression inhibits depolarization-induced exocytosis in PC12 cells
Journal of neuroscience research,
2004; 76(3):
334-41.
Ferguson Gregory D, Wang Hongbing, Herschman Harvey R, Storm Daniel R
Altered hippocampal short-term plasticity and associative memory in synaptotagmin IV (-/-) mice
Hippocampus,
2004; 14(8):
964-74.
Chen Ian Y, Wu Joseph C, Min Jung-Jun, Sundaresan Gobalakrishnan, Lewis Xiaoman, Liang Qianwa, Herschman Harvey R, Gambhir Sanjiv S
Micro-positron emission tomography imaging of cardiac gene expression in rats using bicistronic adenoviral vector-mediated gene delivery
Circulation,
2004; 109(11):
1415-20.
Herschman Harvey R
Molecular imaging: a view from the inside
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
2004; 11(2):
210-4.
Herschman Harvey R
Noninvasive imaging of reporter gene expression in living subjects
Advances in cancer research,
2004; 92(2):
29-80.
Smith Jeffrey B, Herschman Harvey R
Targeted identification of glucocorticoid-attenuated response genes: in vitro and in vivo models
Proceedings of the American Thoracic Society,
2004; 1(3):
275-81.
Symensma Tonia L, Martinez-Guzman DeeAnn, Jia Qingmei, Bortz Eric, Wu Ting-Ting, Rudra-Ganguly Nandini, Cole Steve, Herschman Harvey, Sun Ren
COX-2 induction during murine gammaherpesvirus 68 infection leads to enhancement of viral gene expression
Journal of virology,
2003; 77(23):
12753-63.
Herschman Harvey R, Talley John J, DuBois Raymond
Cyclooxygenase 2 (COX-2) as a target for therapy and noninvasive imaging
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging,
2003; 5(5):
286-303.
Herschman Harvey R
Molecular imaging: looking at problems, seeing solutions
Science (New York, N.Y.),
2003; 302(5645):
605-8.
Herschman Harvey R
Micro-PET imaging and small animal models of disease
Current opinion in immunology,
2003; 15(4):
378-84.
Nguyen Julie T, Machado Hidevaldo, Herschman Harvey R
Repetitive, noninvasive imaging of cyclooxygenase-2 gene expression in living mice
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging,
2003; 5(4):
248-56.
Liu Wei, Feldman Jonathan D, Machado Hidevaldo B, Vician Linda J, Herschman Harvey R
Expression of depolarization-induced immediate early gene proteins in PC12 cells
Journal of neuroscience research,
2003; 72(6):
670-8.
Smith Jeffrey B, Wadleigh David J, Xia Yu-Rong, Mar Rebecca A, Herschman Harvey R, Lusis Aldons J
Cloning and genomic localization of the murine LPS-induced CXC
chemokine (LIX) gene, Scyb5
Immunogenetics,
2002; 54(8):
599-603.
Lin Henry J, Lakkides Karen M, Keku Temitope O, Reddy Srinivasa T, Louie Andrew D, Kau Irving H, Zhou Haiyan, Gim Jason S Y, Ma Hoang L, Matthies Carl F, Dai Aihua, Huang Hsiao-Fen, Materi Alicia M, Lin Jesse H, Frankl Harold D, Lee Eric R, Hardy Steven I, Herschman Harvey R, Henderson Brian E, Kolonel Laurence N, Le Marchand Loïc, Garavito R Michael, Sandler Robert S, Haile Robert W, Smith William L
Prostaglandin H synthase 2 variant (Val511Ala) in African Americans
may reduce the risk for colorectal neoplasia
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
2002; 11(11):
1305-15.
Rudra-Ganguly Nandini, Reddy Srinivasa T, Korge Paavo, Herschman Harvey R
Diesel exhaust particle extracts and associated polycyclic aromatic
hydrocarbons inhibit Cox-2-dependent prostaglandin synthesis in murine
macrophages and fibroblasts
The Journal of biological chemistry,
2002; 277(42):
39259-65.
Smith Jeffrey B, Nguyen Tam T, Hughes Heather J, Herschman Harvey R, Widney Daniel P, Bui Kim C, Rovai Leonor E
Glucocorticoid-attenuated response genes induced in the lung during
endotoxemia
American journal of physiology. Lung cellular and molecular physiology,
2002; 283(3):
L636-47.
Chikazu Daichi, Li Xiaodong, Kawaguchi Hiroshi, Sakuma Yoko, Voznesensky Olga S, Adams Douglas J, Xu Manshan, Hoshio Kazuto, Katavic Vedran, Herschman Harvey R, Raisz Lawrence G, Pilbeam Carol C
Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts
via a Cbfal binding site: role in effects of bone morphogenetic
protein 2 in vitro and in vivo
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
2002; 17(8):
1430-40.
Liang Qianwa, Gotts Jeff, Satyamurthy Nagichettiar, Barrio Jorge, Phelps Michael E, Gambhir Sanjiv S, Herschman Harvey R
Noninvasive, repetitive, quantitative measurement of gene expression
from a bicistronic message by positron emission tomography, following
gene transfer with adenovirus
Molecular therapy : the journal of the American Society of Gene Therapy,
2002; 6(1):
73-82.
Giza Christopher C, Prins Mayumi L, Hovda David A, Herschman Harvey R, Feldman Jonathan D
Genes preferentially induced by depolarization after concussive brain
injury: effects of age and injury severity
Journal of neurotrauma,
2002; 19(4):
387-402.
Cimato Thomas R, Tang Jie, Xu Ye, Guarnaccia Corrado, Herschman Harvey R, Pongor Sandor, Aletta John M
Nerve growth factor-mediated increases in protein methylation occur
predominantly at type I arginine methylation sites and involve protein
arginine methyltransferase 1
Journal of neuroscience research,
2002; 67(4):
435-42.
Herschman Harvey R
Non-invasive imaging of reporter genes
Journal of cellular biochemistry. Supplement,
2002; 39(4):
36-44.
Green Leeta A, Yap Cecelia S, Nguyen Khoi, Barrio Jorge R, Namavari Mohammad, Satyamurthy Nagichettiar, Phelps Michael E, Sandgren Eric P, Herschman Harvey R, Gambhir Sanjiv S
Indirect monitoring of endogenous gene expression by positron emission
tomography (PET) imaging of reporter gene expression in transgenic
mice
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging,
2002; 4(1):
71-81.