Faculty List

(Henry) Sung-Cheng Huang, D.Sc.

Work Email Address: hhuang@mednet.ucla.edu

Fax Number: 310-825-4517

Office Phone Number: 310-825-6647

Huang Lab

Laboratory Address:
B2-085C CHS
Los Angeles, CA 90095

Office Address:
B2-085H CHS
Los Angeles, CA 90095

Department / Division Affiliations
Professor, Biomathematics
Member, JCCC Cancer Molecular Imaging, Molecular Pharmacology GPB Home Area, Physics & Biology in Medicine GPB Home Area
Professor Emeritus, Molecular & Medical Pharmacology

Research Interests
We are interested in the methodology development and applications of quantitative molecular imaging. We develop tracer kinetic models for new compounds as well as various methods to facilitate image quantitation (e.g., movement correction, parametric image generation, image-based input function derivation, partial volume correction, automated ROI procedures). In the application aspect, we collaborate with other laboratories to use quantitative molecular imaging, in preclinical and clinical settings, to study various diseases/disorders, including, coronary artery disease, brain trauma, dementias, and cancers. In kinetic modeling, special emphasis is on the understanding of basic mechanisms related to the uptake, clearance and metabolism of labeled compounds under various conditions. We use mathematical and statistical methods to account for various confounding factors to improve the signal-to-noise ratio in molecular imaging measurements obtained in vivo.


A selected list of publications:

Huang SC   Anatomy of SUV (Standardized Uptake Value), Nuclear Medicine & Biology, 2000; 27: 643-646.
Shoghi-Jadid K, Small GW, Agdeppa ED, Kepe V, Ercoli LM, Siddarth P, Read S, Satyamurthy N, Petric A, Huang SC, Barrio JR   Localization of Neurofibrillary Tangles (NFTs) and Beta-Amyloid Plaques (APs) in the Brains of Living Patients with Alzheimer?s Disease, Am J. Geriatric Psychiatry, 2002; 10: 24-35.
Zhou Y, Huang SC, Bergsneider M, Wong DF   Improved parametric image generation using spatial-temporal analysis of dynamic PET studies, Neuroimaging, , 2002; 15: 697-707.
Huang, SC Stout, DB Yee, RE Satyamurthy, N Barrio, JR   Distribution volume of radiolabeled large neutral amino acids in brain tissue Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. , 1998; 18(12): 1288-93.
Shoghi-Jadid K, Huang SC, Stout DB, Yee RE, Yeh EL, Farahani KF, Satyamurthy N, Phelps ME, Barrio JR   Striatal kinetic modeling of FDOPA with a cerebellar-derived constraint on the distribution volume of 3OMFD: a positron emission tomography (PET) investigation using non-human primates, J. Cereb. Blood Flow Metab, 2000; 20: 1134-1148.
Small, GW Ercoli, LM Silverman, DH Huang, SC Komo, S Bookheimer, SY Lavretsky, H Miller, K Siddarth, P Rasgon, NL Mazziotta, JC Saxena, S Wu, HM Mega, MS Cummings, JL Saunders, AM Pericak-Vance, MA Roses, AD Barrio, JR Phelps, ME   Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America. , 2000; 97(11): 6037-42.
Yee, RE Huang, SC Stout, DB Irwin, I Shoghi-Jadid, K Togaski, DM DeLanney, LE Langston, JW Satyamurthy, N Farahani, KF Phelps, ME Barrio, JR   Nigrostriatal reduction of aromatic L-amino acid decarboxylase activity in MPTP-treated squirrel monkeys: in vivo and in vitro investigations Journal of neurochemistry. , 2000; 74(3): 1147-57.
Bergsneider, M Hovda, DA Lee, SM Kelly, DF McArthur, DL Vespa, PM Lee, JH Huang, SC Martin, NA Phelps, ME Becker, DP   Dissociation of cerebral glucose metabolism and level of consciousness during the period of metabolic depression following human traumatic brain injury Journal of neurotrauma. , 2000; 17(5): 389-401.
Choi Y, Huang SC, Hawkins RA, Kim JY, Kim BT, Hoh CK, Chen K, Phelps ME, Schelbert HR   Quantification of myocardial blood flow using N-13 ammonia and PET: comparison of tracer methods, J. Nucl. Med, 1999; 40: 1045-1055.
Huang, SC, Zhou, Y,   Spatially-coordinated regression for image-wise model fitting to dynamic PET data for generating parametric images., IEEE Transactions on Nuclear Science, 1998; 45: 1194-1199.
Wu, HM Huang, SC Hattori, N Glenn, TC Vespa, PM Yu, CL Hovda, DA Phelps, ME Bergsneider, M   Selective metabolic reduction in gray matter acutely following human traumatic brain injury Journal of neurotrauma. , 2004; 21(2): 149-61.
Hattori, N Huang, SC Wu, HM Yeh, E Glenn, TC Vespa, PM McArthur, D Phelps, ME Hovda, DA Bergsneider, M   Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injury Journal of nuclear medicine : official publication, Society of Nuclear Medicine. , 2003; 44(11): 1709-16.
Agdeppa ED, Kepe V, Petri A, Satyamurthy N, Liu J, Huang SC, Small GW, Cole GM, Barrio JR.   In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile, Neuroscience. , 2003; 117(3):: 723-30.
Small, GW Agdeppa, ED Kepe, V Satyamurthy, N Huang, SC Barrio, JR   In vivo brain imaging of tangle burden in humans Journal of molecular neuroscience : MN. , 2002; 19(3): 323-7.
Wong KP, Zhang, X, Huang, SC,   Improved derivation of input function in dynamic mouse F-18-FDG PET using bladder radioactivity kinetics, Molecular Imaging and Biology, 2013; DOI: 10.1007/s11307-013-0610-6: .
Wilks, M, Protas, H, Wardak, M, Kepe, V, Small, GW, Barrio, JR, Huang, SC   Automated VOI Analysis in FDDNP PET Using Structural Warping: Validation Through Classification of Alzheimer's Disease Patients, International Journal of Alzheimer's Disease, 2012; 2012: 512069.
Leow A, Yu CL, Lee SJ, Huang SC, Nicolson R, Hayashi KM, Protas H, Toga AW, Thompson P,   Brain structural mapping using a noval hybrid implicit/explicit framework based on the level-set method, NeuroImage, 2005; 24(3): 910-927.
Vespa, P, Bergsneider M, Hattori N, Wu HM, Huang SC, Martin NA, Glenn TC, McArthur DL, Hovda DA,   Metabolic Crisis without Brain Ischemia is Common after Traumatic Brain Injury: A Combined Microdialysis and Positron Emission Tomography Study, J Cereb Blood Flow and Metab, 2005; 25(6): 763-774.
Huang SC, Truong D, Wu HM, Chatziioannou AF, Shao W, Wu AM, Phelps ME,   An Internet-based Kinetic Imaging System (KIS) for MicroPET, Molecular Imaging and Biology, 2005; 7: 330-341.
Kepe, V., Barrio, JR, Huang, S.C., Shoghi-Jadid, K., Ercoli, L, Siddarth, P., Cole, G.M., Satyamurthy, N., Small, G.M., Phelps, M.E.,   Serotonin 1A Receptors in the Living Brain of Alzheimer’s Disease Patients, Proceedings of National Academy of Science, 2006; 103(3): 702-707.
Kreissl, M.C., H.M. Wu, D.B. Stout, W. Ladno, T.H. Schindler, X. Zhang, J.O. Prior, A.F. Chatziioannou, S.C. Huang, H.R. Schelbert,   Non-invasive measurement of cardiovascular function in mice with ultra-high temporal resolution small animal PET, J. Nucl. Med, 2006; 47: 974-980.
Small GW, Kepe V, Ercoli LM, Siddarth P, Miller KJ, Bookheimer SY, Lavretsky H, Cole GM, Vinters HV, Thompson PM, Huang S-C, Satyamurthy N, Phelps ME, Barrio JR,   Positron Emission Tomography scanning of cerebral amyloid and Tau deposits in mild cognitive impairment, The New England Journal of Medicine, 2006; 355: 2652-63.
Wu, HM, Sui, G, Lee, CC, Prins, ML, Ladno, W, Lin, HD, Yu, AS, Phelps, ME, Huang, SC,   In vivo quantitation of glucose metabolism in mice using microPET imaging and a microfluidic device, J. Nucl. Med, 2007; 48(5): 837-845.
Ferl, G.Z., Wu, H.M., Zhang, X., Kreissl, M.C., Huang, S.C.   Estimation of the 18F-FDG Input Function in Mice Using Dynamic microPET and Minimal Blood Sample Data, Journal of Nuclear Medicine, 2007; 48: 2037-2045.
Barrio, JR, Kepe, V, Satyamurthy, N, Huang, SC   Amyloid and Tau Imaging, Neuronal Losses and Function in Early Dementia, Journal of Health, Nutrition and Aging, 2008; 12: 61-68.
Huang, SC   Role of kinetic modeling in biomedical imaging, Journal of Medical Sciences/NDMC, 2008; 28(2): 057-064.
Pan, MH, Huang, SC, Liao, YP, Schaue, D, Wang, CC, Stout, DB, Barrio, JR, McBride, WH   3’[F-18]fluoro-3’-deosythymidine (FLT)-PET imaging of radiation responses in murine tumors, Molecular Imaging and Biology, 2008; 10: 325-334.
Ferl, G.Z., Dumont, R, Armijo, A, Haubner, R, Reischl, G, Hildebrandt, I, Su, H, Weber, W, Huang, SC   Derivation of a compartmental model for quantifying 64Cu-RGD peptide kinetics in tumor bearing mice, Journal of Nuclear Medicine, 2009; 50: 250-258.
Wardak, M., Wong, K.P., Shao, W., Dahlbom, M., Kepe, V., Satyamurthy, N., Small, G.W., Barrio, J.R., Huang, S.C.   Movement Correction for Improving Quantitative Analysis of Dynamic Brain 18F-FDDNP PET Images, Journal Nucl. Med, 2010; 51: 210–218.
Wong, KP, Wardak, M, Shao, W, Dahlbom M, Kepe, V, Liu, J, Satyamurthy, N, Small, GW, Barrio, JR, Huang, SC   Quantitative analysis of [F-18]FDDNP PET using subcortical white matter as reference region, European Journal of Nuclear Medicine, 2010; 37(3): 575-88.
Protas, H, Huang, SC, Kepe, V, Hayashi, K, Klunder, A, Braskie, MN, Ercoli, L, Bookheimer, S, Thompson, PM, Small, GW, Barrio, JR   FDDNP binding using MR derived cortical surface maps, NeuroImage, 2010; 49: 240-8.
Yu, AS, Hiryama, BA, Timbol, G, Liu, J, Basarah, E, Kepe, V, Satyamurthy, N, Huang, SC, Wright, EW, Barrio, JR   Functional expression of SGLTs in rat brain, American Journal of Physiology - Cell Physiology, 2010; 299(6): C1277-84.
Schiepers, C, Dahlbom, M, Chen, W, Cloughesy, T, Czernin, J, Phelps, ME, Huang, SC   Kinetics of 3’-deoxy-3’-[18F]fluoro-thymidine during treatment monitoring of recurrent high-grade glioma, J. Nucl. Med, 2010; 51: 720-7.
Wardak, M, Schiepers, C, Dahlbom, M., Satyamurthy, N, Cloughesy, T, Chen, W, Czernin, J, Phelps, ME, Huang, SC   Predicting Survival in Recurrent Brain Tumor Therapy with 18F-Fluoro-Thymidine PET, Clinical Cancer Research, 2011; 17: 6553-62.
Wong, KP, Sha, W, Zhang, X, Huang, SC   Effects of Administration Route, Dietary Condition and Blood Glucose Level on Kinetics and Uptake of 2-[18F]Fluoro-2-deoxy-D-glucose in Mice, J. Nucl. Med, 2011; 52: 800-807.
Maddahi J, Czernin J, Lazewatsky J, Huang SC, Dahlbom M, Schelbert H, Sparks R, Ehlgen A, Crane P, Zhu Q, Devine M, Phelps M   Phase I, First-in-Human Study of BMS747158, a Novel 18F-Labeled Tracer for Myocardial Perfusion PET: Dosimetry, Biodistribution, Safety, and Imaging Characteristics After a Single Injection at Rest, J. Nucl. Med, 2011; 52(9): 1490-1498.
Small, GW, Siddarth, P, Kepe, V, Ercoli, LM, Burggren AC, Bookheimer, SY, Miller, KJ, Kim, J, Lavretsky, H, Huang, S-C, Barrio, JR   PET of brain amyloid and tau predicts and tracks cognitive decline in people without dementia, Archives of Neurology, 2012; 69(2): 215-222.
Wong, KP, Kepe, V, Dahlbom, M, Satyamurthy, N, Small, GW, Barrio, JR, Huang, SC   Comparative evaluation of Logan and relative-equilibrium graphical methods for parametric imaging of dynamic [F-18]FDDNP PET determinations, NeuroImage, 2012; 60(1): 241-251.
Kepe, V, Moghbel, MC, Langstrom, B, Zaidi, H, Vinters, H, Huang, SC, Satyamurthy, N, Doudet, D, Mishani, E, Cohen, R, Hoilund-Carlsen, PF, Alavi, A, Barrio, JR   Amyloid-â Positron Emission Tomography Imaging Probes: A Critical Review, J. Alzheimer’s Disease, 2013; doi: 10.3233/JAD-130485: .
Sha, W, Ye, H, Iwamoto, KS, Wong, KP, Stout, D, McBride, W, Huang, SC   Factors Affecting Tumor FDG Uptake in Longitudinal Mouse PET Studies, EJNMMI Research, 2013; 3:51: .