FACULTY RESEARCH

Faculty List

Srinivasa T. Reddy, Ph.D.

Work Email Address: sreddy@mednet.ucla.edu

Lab Number: 310-206-3605
310-794-5819

Office Phone Number: 310-206-3915

Laboratory Address:
A-8 122 CHS
650 Charles E. Young Drive South
Los Angeles, CA 90095 43-153 CHS

Office Address:
43-144 CHS

Department / Division Affiliations
Professor In-Residence, Medicine, Obstetrics and Gynecology, Molecular & Medical Pharmacology
Member, California NanoSystems Institute, Interdepartmental Program in Molecular Toxicology, Molecular Biology Institute, Molecular Pharmacology GPB Home Area, Molecular, Cellular & Integrative Physiology GPB Home Area, Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC)
Faculty, Cardiology

Research Interests
Inflammatory signals, including exogenous mediators such as lipopolysaccharide and endogenous mediators such as cytokines, stimulate cellular phospholipase (PLA2) activities resulting in the release of arachidonic acid from membrane phospholipid stores. Arachidonic acid is converted into prostaglandins, prostacyclins and thromboxanes by the cyclooxygenase (COX) pathway or leukotrienes and hydroxyeicosatetraenoic acids (HETEs) by the lipoxygenase (LO) pathway. Prostaglandins and other derivatives of arachidonic acid metabolism, are involved in a number of physiological and pathophysiological phenomenon including: acute and chronic inflammation, cardiovascular disease, immune response, arthritis, inflammatory bowel disease, respiratory disorders and colon cancer. My laboratory is interested in understanding the expression and regulation of enzymes involved in arachidonic acid metabolism, especially, cyclooxygenases, lipoxygenases and phospholipases and their role in the development of cardiovascular diseases such as atherosclerosis. Currently, my laboratory is looking at the role of cyclooxygenases in atherosclerotic lesion formation using animal models. Atherosclerosis Research Unit (ARU) at UCLA identified a series of biologically active oxidized lipids, derived from an arachidonic acid containing phospholipid; palmitoyl arachidonyl phosphatidyl choline (PAPC). These oxidized lipids are potent mediators of monocyte adhesion and migration, which is an early event in the development of atherosclerotic lesions. In collaboration with ARU faculty, we completed a screen to identify genes, whose expression is regulated by the biologically active oxidized lipids in human aortic endothelial cells. We have cloned a number of interesting genes and are currently in the process of characterizing some of thege genes and determining their role in the development of atherosclerotic lesions in animal models.

For more detailed information, please visit the lab website.



Publications

A selected list of publications:

Meriwether David, Sulaiman Dawoud, Volpe Carmen, Dorfman Anna, Grijalva Victor, Dorreh Nasrin, Solorzano-Vargas R Sergio, Wang Jifang, O'Connor Ellen, Papesh Jeremy, Larauche Muriel, Trost Hannah, Palgunachari Mayakonda N, Anantharamaiah G M, Herschman Harvey R, Martin Martin G, Fogelman Alan M, Reddy Srinivasa T   Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model The Journal of clinical investigation, 2019; 130(6): .
Cedó Lídia, Reddy Srinivasa T, Mato Eugènia, Blanco-Vaca Francisco, Escolà-Gil Joan Carles   HDL and LDL: Potential New Players in Breast Cancer Development Journal of clinical medicine, 2019; 8(6): .
Shih Diana M, Meng Yonghong, Sallam Tamer, Vergnes Laurent, Shu Michelle L, Reue Karen, Tontonoz Peter, Fogelman Alan M, Lusis Aldons J, Reddy Srinivasa T   PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity Antioxidants (Basel, Switzerland), 2019; 8(1): 154-164.
Sulaiman Dawoud, Li Jingyuan, Devarajan Asokan, Cunningham Christine Marie, Li Min, Fishbein Gregory A, Fogelman Alan M, Eghbali Mansoureh, Reddy Srinivasa T   Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway Journal of molecular and cellular cardiology, 2019; 129(6): 154-164.
Morgantini C, Trifirò S, Tricò D, Meriwether D, Baldi S, Mengozzi A, Reddy S T, Natali A   A short-term increase in dietary cholesterol and fat intake affects high-density lipoprotein composition in healthy subjects Nutrition, metabolism, and cardiovascular diseases : NMCD, 2018; 28(6): 575-581.
Guirgis Faheem W, Leeuwenburgh Christiaan, Grijalva Victor, Bowman Jennifer, Kalynych Colleen, Moldawer Lyle, Moore Frederick A, Reddy Srinivasa T   HDL Cholesterol Efflux is Impaired in Older Patients with Early Sepsis: A Subanalysis of a Prospective Pilot Study Shock (Augusta, Ga.), 2018; 50(1): 66-70.
Guirgis Faheem W, Dodani Sunita, Leeuwenburgh Christiaan, Moldawer Lyle, Bowman Jennifer, Kalynych Colleen, Grijalva Victor, Reddy Srinivasa T, Jones Alan E, Moore Frederick A   HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock PloS one, 2018; 13(9): e0203813.
Charles-Schoeman Christina, Meriwether David, Lee Yuen Yin, Shahbazian Ani, Reddy Srinivasa T   High levels of oxidized fatty acids in HDL are associated with impaired HDL function in patients with active rheumatoid arthritis Clinical rheumatology, 2018; 37(3): 615-622.
Singh Rajan, Pervin Shehla, Lee Se-Jin, Kuo Alan, Grijalva Victor, David John, Vergnes Laurent, Reddy Srinivasa T   Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases Diabetes, metabolic syndrome and obesity : targets and therapy, 2018; 11: 65-84.
Devarajan Asokan, Su Feng, Grijalva Victor, Yalamanchi Meghna, Yalamanchi Ashna, Gao Feng, Trost Hannah, Nwokedi Josephine, Farias-Eisner Gina, Farias-Eisner Robin, Fogelman Alan M, Reddy Srinivasa T   Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer Cell death & disease, 2018; 9(3): 392.
Li Wei, Kennedy David, Shao Zhili, Wang Xi, Kamdar Andre Klaassen, Weber Malory, Mislick Kayla, Kiefer Kathryn, Morales Rommel, Agatisa-Boyle Brendan, Shih Diana M, Reddy Srinivasa T, Moravec Christine S, Tang W H Wilson   Paraoxonase 2 prevents the development of heart failure Free radical biology & medicine, 2018; 121: 117-126.
Charles-Schoeman C, Gugiu G B, Ge H, Shahbazian A, Lee Y Y, Wang X, Furst D E, Ranganath V K, Maldonado M, Lee Terry, Reddy S T   Remodeling of the HDL proteome with treatment response to abatacept or adalimumab in the AMPLE trial of patients with rheumatoid arthritis Atherosclerosis, 2018; 275: 107-114.
Mukherjee Pallavi, Hough Greg, Chattopadhyay Arnab, Grijalva Victor, O'Connor Ellen Ines, Meriwether David, Wagner Alan, Ntambi James M, Navab Mohamad, Reddy Srinivasa T, Fogelman Alan M   Role of enterocyte stearoyl-Co-A desaturase-1 in LDLR-null mice Journal of lipid research, 2018; 59(10): 1818-1840.
Chattopadhyay Arnab, Yang Xinying, Mukherjee Pallavi, Sulaiman Dawoud, Fogelman Hannah R, Grijalva Victor, Dubinett Steven, Wasler Tonya C, Paul Manash K, Salehi-Rad Ramin, Mack Julia J, Iruela-Arispe M Luisa, Navab Mohamad, Fogelman Alan M, Reddy Srinivasa T   Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer Scientific reports, 2018; 8(1): 9032.
Guirgis Faheem W, Dodani Sunita, Moldawer Lyle, Leeuwenburgh Christiaan, Bowman Jennifer, Kalynych Colleen, Jones Alan E, Reddy Srinivasa T, Moore Frederick A   Exploring the Predictive Ability of Dysfunctional High-Density Lipoprotein for Adverse Outcomes in Emergency Department Patients with Sepsis: A Preliminary Investigation Shock (Augusta, Ga.), 2017; 48(5): 539-544.
Singh Rajan, Braga Melissa, Reddy Srinivasa T, Lee Se-Jin, Parveen Meher, Grijalva Victor, Vergnes Laurent, Pervin Shehla   Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues Endocrinology, 2017; 158(5): 1217-1230.
Charles-Schoeman Christina, Yin Lee Yuen, Shahbazian Ani, Wang Xiaoyan, Elashoff David, Curtis Jeffrey R, Navarro-Millán Iris, Yang Shuo, Chen Lang, Cofield Stacey S, Moreland Larry W, Paulus Harold, O'Dell James, Bathon Joan, Louis Bridges S, Reddy Srinivasa T   Improvement of High-Density Lipoprotein Function in Patients With Early Rheumatoid Arthritis Treated With Methotrexate Monotherapy or Combination Therapies in a Randomized Controlled Trial Arthritis & rheumatology (Hoboken, N.J.), 2017; 69(1): 46-57.
Mukherjee Pallavi, Hough Greg, Chattopadhyay Arnab, Navab Mohamad, Fogelman Hannah R, Meriwether David, Williams Kevin, Bensinger Steven, Moller Travis, Faull Kym F, Lusis Aldons J, Iruela-Arispe M Luisa, Bostrom Kristina I, Tontonoz Peter, Reddy Srinivasa T, Fogelman Alan M   Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum Journal of lipid research, 2017; 58(8): 1636-1647.
Cedó Lídia, García-León Annabel, Baila-Rueda Lucía, Santos David, Grijalva Victor, Martínez-Cignoni Melanie Raquel, Carbó José M, Metso Jari, López-Vilaró Laura, Zorzano Antonio, Valledor Annabel F, Cenarro Ana, Jauhiainen Matti, Lerma Enrique, Fogelman Alan M, Reddy Srinivasa T, Escolà-Gil Joan Carles, Blanco-Vaca Francisco   ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer Scientific reports, 2016; 6: 36387.
Mehta Niyati U, Grijalva Victor, Hama Susan, Wagner Alan, Navab Mohamad, Fogelman Alan M, Reddy Srinivasa T   Apolipoprotein E-/- Mice Lacking Hemopexin Develop Increased Atherosclerosis via Mechanisms That Include Oxidative Stress and Altered Macrophage Function Arteriosclerosis, thrombosis, and vascular biology, 2016; 36(6): 1152-63.
Sharma Salil, Ruffenach Grégoire, Umar Soban, Motayagheni Negar, Reddy Srinivasa T, Eghbali Mansoureh   Role of oxidized lipids in pulmonary arterial hypertension Pulmonary circulation, 2016; 6(3): 261-73.
Chattopadhyay Arnab, Navab Mohamad, Hough Greg, Grijalva Victor, Mukherjee Pallavi, Fogelman Hannah R, Hwang Lin H, Faull Kym F, Lusis Aldons J, Reddy Srinivasa T, Fogelman Alan M   Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD Journal of lipid research, 2016; 57(5): 832-47.
Meriwether David, Sulaiman Dawoud, Wagner Alan, Grijalva Victor, Kaji Izumi, Williams Kevin J, Yu Liqing, Fogelman Spencer, Volpe Carmen, Bensinger Steven J, Anantharamaiah G M, Shechter Ishaiahu, Fogelman Alan M, Reddy Srinivasa T   Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal cholesterol efflux Journal of lipid research, 2016; 57(7): 1175-93.
Sharma Salil, Umar Soban, Potus Francois, Iorga Andrea, Wong Gabriel, Meriwether David, Breuils-Bonnet Sandra, Mai Denise, Navab Kaveh, Ross David, Navab Mohamad, Provencher Steeve, Fogelman Alan M, Bonnet Sébastien, Reddy Srinivasa T, Eghbali Mansoureh   Apolipoprotein A-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p Circulation, 2014; 130(9): 776-85.