Department / Division Affiliations
|Chair, and Professor, Obstetrics and Gynecology|
|Professor, Molecular & Medical Pharmacology|
|Member, Internal Advisory Board, CTSI, JCCC Signal Transduction and Therapeutics Program Area, Workforce Development|
Studies are carried out on the mechanism by which estradiol and nitric oxide modulate various physiological functions and the signal transduction pathways involved. The major focus is on the cardiovascular system and breast cancer.
A selected list of publications:
van Nas, Guhathakurta, Wang, Yehya, Horvath, Zhang, Ingram-Drake, Chaudhuri, Schadt, Drake, Arnold, Lusis Elucidating the Role of Gonadal Hormones in Sexually Dimorphic Gene Co-Expression Networks Endocrinology, 2008; .
Pervin Shehla, Singh Rajan, Chaudhuri Gautam Nitric oxide, N omega-hydroxy-L-arginine and breast cancer Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society, 2008; 19(2): 103-6.
Souter, Huang, Martinez-Maza, Crabb Breen, Decherney, Chaudhuri, Nathan Serum levels of soluble vascular cell adhesion molecule-1, tumor necrosis factor-alpha, and interleukin-6 in in vitro fertilization cycles Fertility and sterility, 2008; .
Pervin Shehla, Tran An H, Zekavati Shaghayegh, Fukuto Jon M, Singh Rajan, Chaudhuri Gautam Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis Cancer research, 2008; 68(12): 4862-74.
Chaudhuri Gautam Nuclear receptors and female reproduction: a tale of 3 scientists, Jensen, Gustafsson, and O'Malley Reproductive sciences (Thousand Oaks, Calif.), 2008; 15(2): 110-20.
Friedlander Arthur H, Chaudhuri Gautam, Altman Lisa A past medical history of gestational diabetes: its medical significance and its dental implications Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2007; 103(2): 157-63.
Pervin Shehla, Singh Rajan, Hernandez Estebes, Wu Guoyao, Chaudhuri Gautam Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway Cancer research, 2007; 67(1): 289-99.
Hayashi Toshio, Esaki Teiji, Sumi Daigo, Mukherjee Tapan, Iguchi Akihisa, Chaudhuri Gautam Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(27): 10485-90.
Souter Irene, Janzen Carla, Martinez-Maza Otoniel, Breen Elizabeth Crabb, Stanczyk Frank, Chaudhuri Gautam, Nathan Lauren Serum levels of soluble vascular cell adhesion molecule-1 are decreased in women receiving oral contraceptives compared with normally menstruating women: implications in atherosclerosis Fertility and sterility, 2005; 83(5): 1480-8.
López-Jaramillo Patricio, Díaz Luis Alfonso, Pardo Alberto, Parra Gustavo, Jaimes Hermes, Chaudhuri Gautam Estrogen therapy increases plasma concentrations of nitric oxide metabolites in postmenopausal women but increases flow-mediated vasodilation only in younger women Fertility and sterility, 2004; 82(6): 1550-5.
Pervin Shehla, Singh Rajan, Freije William A, Chaudhuri Gautam MKP-1-induced dephosphorylation of extracellular signal-regulated kinase is essential for triggering nitric oxide-induced apoptosis in human breast cancer cell lines: implications in breast cancer Cancer research, 2003; 63(24): 8853-60.
Han Tae H, Qamirani Erion, Nelson Allyson G, Hyduke Daniel R, Chaudhuri Gautam, Kuo Lih, Liao James C Regulation of nitric oxide consumption by hypoxic red blood cells Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(21): 12504-9.
Mukherjee Tapan K, Nathan Lauren, Dinh Hillary, Reddy Srinivasa T, Chaudhuri Gautam 17-epiestriol, an estrogen metabolite, is more potent than estradiol in inhibiting vascular cell adhesion molecule 1 (VCAM-1) mRNA expression The Journal of biological chemistry, 2003; 278(14): 11746-52.
Berman Jennifer R, Almeida Fernando G, Jolin Julie, Raz Shlomo, Chaudhuri Gautam, Gonzalez-Cadavid Nestor F Correlation of androgen receptors, aromatase, and 5-alpha reductase in the human vagina with menopausal status Fertility and sterility, 2003; 79(4): 925-31.
Singh Rajan, Pervin Shehla, Chaudhuri Gautam Caspase-8-mediated BID cleavage and release of mitochondrial cytochrome c during Nomega-hydroxy-L-arginine-induced apoptosis in MDA-MB-468 cells. Antagonistic effects of L-ornithine The Journal of biological chemistry, 2002; 277(40): 37630-6.
Mukherjee Tapan K, Dinh Hillary, Chaudhuri Gautam, Nathan Lauren Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to estradiol by aromatase in endothelial cells: implications in atherosclerosis Proceedings of the National Academy of Sciences of the United States of America, 2002; 99(6): 4055-60.
Campisi Roxana, Nathan Lauren, Pampaloni Miguel Hernandez, Schöder Heiko, Sayre James W, Chaudhuri Gautam, Schelbert Heinrich R Noninvasive assessment of coronary microcirculatory function in postmenopausal women and effects of short-term and long-term estrogen administration Circulation, 2002; 105(4): 425-30.
Nathan L, Pervin S, Singh R, Rosenfeld M, Chaudhuri G Estradiol inhibits leukocyte adhesion and transendothelial migration in rabbits in vivo : possible mechanisms for gender differences in atherosclerosis Circulation research. , 1999; 85(4): 377-85.
Pervin Shehla, Chaudhuri Gautam, Singh Rajan NO to breast: when, why and why not? Current pharmaceutical design, 2010; 16(4): 451-62.
Pervin Shehla, Singh Rajan, Chaudhuri Gautam Nitric-oxide-induced Bax integration into the mitochondrial membrane commits MDA-MB-468 cells to apoptosis: essential role of Akt Cancer research, 2003; 63(17): 5470-9.
Fung Camille, Evans Edward, Shin Don, Shin Bo-Chul, Zhao Yuanzi, Sankar Raman, Chaudhuri Gautam, Devaskar Sherin U Hypoxic-ischemic brain injury exacerbates neuronal apoptosis and precipitates spontaneous seizures in glucose transporter isoform 3 heterozygous null mice Journal of neuroscience research, 2010; 88(15): 3386-98.
Janzen Carla, Sen Suvajit, Cuevas Janis, Reddy Srinivasa T, Chaudhuri Gautam Protein phosphatase 2A promotes endothelial survival via stabilization of translational inhibitor 4E-BP1 following exposure to tumor necrosis factor-Î± Arteriosclerosis, thrombosis, and vascular biology, 2011; 31(11): 2586-94.
Sen Suvajit, Kawahara Brian, Chaudhuri Gautam Mitochondrial-associated nitric oxide synthase activity inhibits cytochrome c oxidase: implications for breast Cancer Free radical biology & medicine, 2013; 57: 210-20.
Pervin Shehla, Hewison Martin, Braga Melissa, Tran Lac, Chun Rene, Karam Amer, Chaudhuri Gautam, Norris Keith, Singh Rajan Down-regulation of vitamin D receptor in mammospheres: implications for vitamin D resistance in breast cancer and potential for combination therapy PloS one, 2013; 8(1): e53287.
Sen Suvajit, Kawahara Brian, Chaudhuri Gautam Maintenance of higher HâOâ levels, and its mechanism of action to induce growth in breast cancer cells: important roles of bioactive catalase and PP2A Free radical biology & medicine, 2012; 53(8): 1541-51.