Department / Division Affiliations
|Professor, Pediatrics, Pediatric Infectious Diseases, Molecular & Medical Pharmacology|
|Member, Care 4 Kids, Youth, and Moms, Immunity, Microbes & Molecular Pathogenesis GPB Home Area, Molecular Pharmacology GPB Home Area|
Our laboratory focuses on molecular virology and the pathogenesis of AIDS and other viral diseases. Major areas of interest include the role that cellular proteins play in promoting the assembly of viral proteins into infectious HIV particles, and virus release from infected cells. Our studies of AIDS pathogenesis currently include the impact of HIV on T cell production and turnover in HIV infected children and adolescents. These studies may suggest new forms of therapy for HIV infection that target viral-cellular interactions, and in new approaches to the reversing immunological impact of HIV on immunological ontogeny. Our laboratory research also includes molecular approaches to the identification of novel agents involved in idiopathic liver failure, and cellular factors involved in Coxsackie myocarditis. In addition, we have lead and collaborated in studies of the pharmacokinetics and pharmacodynamics of new drugs for the treatment of HIV infection in children.
A selected list of publications:
Phung Jennifer, Krogstad Paul, Mathern Gary W Etiology associated with developing posthemispherectomy hydrocephalus after resection-disconnection procedures Journal of neurosurgery. Pediatrics, 2013; .
Cammock C, Halnon NJ, Singletary M, Skoczylas J, Blanchard J, Bohm R, Chi L, Krogstad P Myocarditis, Disseminated infection, and Early Viral Persistence Following Experimental Coxsackievirus B Infection of Cynomolgus Monkeys, PLOS-One, 2013; In press: .
Phung Jennifer, Mathern Gary W, Krogstad Paul Timing and predictors of fever and infection after craniotomy for epilepsy in children The Pediatric infectious disease journal, 2013; 32(5): 450-9.
Zuo Jun, Quinn Kevin K, Kye Steve, Cooper Paige, Damoiseaux Robert, Krogstad Paul Fluoxetine is a potent inhibitor of coxsackievirus replication Antimicrobial agents and chemotherapy, 2012; 56(9): 4838-44.
Zuo J, Quinn KK, Kye S, Cooper P, Damoiseaux R, and Krogstad P Fluoxetine is a Potent Inhibitor of Coxsackievirus Replication, Antimicrobial Agents and Chemotherapy, 2012; 6: 4838-4844.
Zuo J, Suen J, Wong A, Lewis M, Ali A, Belzer M, Church J, Yang OO, and Krogstad P. Functional Analysis of HIV-1 Nef Gene Variants from Adolescent and Adult Survivors of Pediatric Infection. , AIDS Research Human Retroviruses , 2012; 28: 486-92..
Zuo Jun, Suen Jeffrey, Wong Alanna, Lewis Martha, Ayub Ali, Belzer Marvin, Church Joseph, Yang Otto O, Krogstad Paul Functional analysis of HIV type 1 Nef gene variants from adolescent and adult survivors of perinatal infection AIDS research and human retroviruses, 2012; 28(5): 486-92.
Marsden Matthew D, Krogstad Paul A, Zack Jerome A Virological evidence supporting the use of raltegravir in HIV post-exposure prophylaxis regimens Antiviral therapy, 2012; 17(7): 1375-9.
Krogstad Paul, Aldrovandi Grace Editorial: developmental regulation of P-glycoprotein and HIV therapy: spare the thymus but spoil the child? Journal of leukocyte biology, 2011; 90(4): 639-41.
Mangione-Smith Rita, Krogstad Paul Antibiotic prescription with asthma medications: why is it so common? Pediatrics, 2011; 127(6): 1174-6.
Mochon A Brian, Garner Omai B, Hindler Janet A, Krogstad Paul, Ward Kevin W, Lewinski Michael A, Rasheed James K, Anderson Karen F, Limbago Brandi M, Humphries Romney M New Delhi metallo-Î²-lactamase (NDM-1)-producing Klebsiella pneumoniae: case report and laboratory detection strategies Journal of clinical microbiology, 2011; 49(4): 1667-70.
Rudy Bret J, Kapogiannis Bill G, Lally Michelle A, Gray Glenda E, Bekker Linda-Gail, Krogstad Paul, McGowan Ian Youth-specific considerations in the development of preexposure prophylaxis, microbicide, and vaccine research trials Journal of acquired immune deficiency syndromes (1999), 2010; 54 Suppl 1(4): S31-42.
Zuo Jun, Church Joseph, Belzer Marvin, Kitchen Christina, Ank Bonnie, Schmid Ingrid, Krogstad Paul Short communication: enhanced CD8+ T cell apoptosis in HIV-infected adolescents with virologic failure on protease inhibitor-based therapy AIDS research and human retroviruses, 2010; 26(6): 681-4.
Wolf Mike C, Freiberg Alexander N, Zhang Tinghu, Akyol-Ataman Zeynep, Grock Andrew, Hong Patrick W, Li Jianrong, Watson Natalya F, Fang Angela Q, Aguilar Hector C, Porotto Matteo, Honko Anna N, Damoiseaux Robert, Miller John P, Woodson Sara E, Chantasirivisal Steven, Fontanes Vanessa, Negrete Oscar A, Krogstad Paul, Dasgupta Asim, Moscona Anne, Hensley Lisa E, Whelan Sean P, Faull Kym F, Holbrook Michael R, Jung Michael E, Lee Benhur A broad-spectrum antiviral targeting entry of enveloped viruses Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(7): 3157-62.
Kitchen Christina M R, Krogstad Paul, Kitchen Scott G In Vivo validation of a bioinformatics based tool to identify reduced replication capacity in HIV-1 The open medical informatics journal, 2010; 4(7): 225-32.
Bekmezian Arpi, Vargas Jorge, Krogstad Paul Jaundice in a neonate with congenital diaphragmatic hernia Paediatrics & child health, 2009; 14(6): 389-92.
Miller John P, Geng Yongzhi, Ng Hwee L, Yang Otto O, Krogstad Paul Packaging limits and stability of HIV-1 sequences in a coxsackievirus B vector Vaccine, 2009; 27(30): 3992-4000.
Chatila Talal A, Krogstad Paul Crouching tigers, hidden dragons: the interplay of pathogens and hosts Pediatric research, 2009; 65(5 Pt 2): 1R-2R.
Krogstad Paul, Hammon Rebecca, Halnon Nancy, Whitton J Lindsay Fatal neonatal myocarditis caused by a recombinant human enterovirus-B variant The Pediatric infectious disease journal, 2008; 27(7): 668-9.
Kitchen Christina Mr, NuÃ±o Miriam, Kitchen Scott G, Krogstad Paul Enfuvirtide antiretroviral therapy in HIV-1 infection Therapeutics and clinical risk management, 2008; 4(2): 433-9.
Krogstad Paul, Cherry James D Quadrivalent human vaccine - a call to action and for additional research Pediatric research, 2007; 62(5): 527.
Krogstad Paul A Resistance to antiretroviral drugs: a threat to the prevention and treatment of pediatric HIV infection The Journal of infectious diseases, 2007; 195(10): 1393-5.
Lee JC, Boechat MI, Belzer M, Church JA, De Ville J, Nielsen K, Weston S, Geng Y, Dunaway T, Kitchen C, and Krogstad PA Thymic volume, T-cell populations, and parameters of thymopoiesis in adolescent and adult survivors of HIV infection acquired in infancy, AIDS, 2006; 20: 667-674.
Yang OO, Church J, Kitchen CMR, Kilpatrick R, Ali A, Geng Y, Killian MS, Lubong R, Ng H, Suen J, Bryson Y, Jamieson B, and Krogstad P Genetic and stochastic influences on the interaction of HIV-1 and CTL in identical twins Journal of Virology , 2005; 79: 15368-75.